Pretransplant Serum Levels of C-Reactive Protein Predict Prognoses in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma

2015 ◽  
Vol 47 (3) ◽  
pp. 686-693 ◽  
Author(s):  
Y.-K. Kim ◽  
S.H. Kim ◽  
S.D. Lee ◽  
S.K. Hong ◽  
S.-J. Park
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein as a biomarker to predict outcomes after liver transplantation for hepatocellular carcinoma.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 4086-4086
Author(s):  
H. J. An ◽  
J. W. Jang ◽  
M. A. Lee ◽  
S. H. Bae ◽  
J. Y. Choi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
C Reactive Protein ◽  
Reactive Protein

Postoperative peak serum C-reactive protein is a predictor of outcome following liver transplantation for hepatocellular carcinoma

Biomarkers ◽  
2015 ◽  
Vol 21 (2) ◽  
pp. 152-159 ◽  
Author(s):  
Arno Kornberg ◽  
Ulrike Witt ◽  
Jennifer Kornberg ◽  
Katharina Müller ◽  
Helmut Friess ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Peak Serum ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-reactive protein is an independent predictor for hepatocellular carcinoma recurrence after liver transplantation

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216677 ◽  
Author(s):  
Tobias Meischl ◽  
Susanne Rasoul-Rockenschaub ◽  
Georg Györi ◽  
Wolfgang Sieghart ◽  
Thomas Reiberger ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Independent Predictor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hepatocellular Carcinoma Recurrence

scholarly journals Serum C‐reactive protein is a useful biomarker for predicting outcomes after liver transplantation in patients with hepatocellular carcinoma

2012 ◽  
Vol 18 (12) ◽  
pp. 1406-1414 ◽  
Author(s):  
Ho Jung An ◽  
Jeong Won Jang ◽  
Si Hyun Bae ◽  
Jong Young Choi ◽  
Seung Kew Yoon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
C Reactive Protein ◽  
Reactive Protein

CIRCULATING SERUM LEVELS OF INTERLEUKIN 6 AND C-REACTIVE PROTEIN AFTER LIVER TRANSPLANTATION

1992 ◽  
Vol 54 (1) ◽  
pp. 142-146 ◽  
Author(s):  
H. TILG ◽  
J. NORDBERG ◽  
W. VOGEL ◽  
T. A. LUGER ◽  
M. HEROLD ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Interleukin 6 ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein

Brain-derived neurotrophic factor is associated with coronary macrophage infiltrates in patients with acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R.A Montone ◽  
M Camilli ◽  
M Russo ◽  
M Del Buono ◽  
F Gurguglione ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
C Reactive Protein ◽  
St Segment Elevation ◽  
Protein Levels ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
St Segment

Abstract Background Brain-derived neurotrophic factor (BDNF) is a neurotrophine that plays a key role in the regulation of both central and peripheral nervous system. Moreover, BDNF is secreted in multiple tissues and exerts systemic, autocrine, and paracrine effects in the cardiovascular system. Of importance, BDNF expression was enhanced in macrophages and smooth muscle cells in atherosclerotic coronary arteries and may be involved in thrombus formation. Thus, BDNF has been suggested as an important link between inflammation and thrombosis, potentially involved in the pathogenesis of acute coronary syndrome (ACS). Purpose In our study we aimed at assessing serum levels of BDNF in patients with ACS, evaluating differences according to clinical presentation [ST-segment elevation myocardial infarction (STEMI) vs. Non-ST-segment elevation ACS (NSTE-ACS)]. Moreover, we assessed the presence of optical coherence (OCT)-defined macrophage infiltrates (MØI) in the culprit vessel of ACS patients and evaluated their relationship with BDNF levels. Methods ACS patients were prospectively selected. Blood samples were collected at admission and serum levels of BDNF were subsequently assessed. Presence of OCT-defined MØI along the culprit vessel was assessed. Results 166 ACS patients were enrolled [mean age 65.3±11.9 years, 125 (75.3%) male, 109 STEMI, 57 NSTE-ACS]. Serum levels of BDNF were higher among STEMI patients compared with NSTE-ACS [median (IQR) 2.48 pg/mL (1.54–3.34) vs. 2.12 pg/mL (1.34–2.47), p=0.007], while C-reactive protein levels did not differ between the two groups. OCT assessment was performed in 53 patients and MØI were detected in 27 patients. Of importance, patients with MØI in the culprit vessel had higher levels of BDNF compared with patients without MØI [median (IQR) 2.23 pg/mL (1.38–2.53) vs. 1.41 pg/mL (0.93–2.07), p=0.023], while C-reactive protein levels did not differ between the two groups. Of note, at multivariate regression analysis BDNF levels were independent predictor of MØI [OR: 2.20; 95% CI (1.02–4.74), p=0.043]. Conclusions Serum levels of BDNF may reliable identify the presence of local macrophage inflammatory infiltrates in patients with ACS. Moreover, BDNF levels are higher in patients with STEMI compared with NSTE-ACS. Taken together, these data suggest that BDNF may represent an interesting link between local inflammatory activation and enhanced thrombosis in ACS. BDNF serum levels Funding Acknowledgement Type of funding source: None

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