scholarly journals Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: True Association or EPIphenomenon?

2019 ◽  
Vol 64 (7) ◽  
pp. 1731-1733
Author(s):  
Salmaan Jawaid ◽  
Chris E. Forsmark
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
True Association

Exocrine pancreatic insufficiency following acute pancreatitis: Systematic review and meta-analysis

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S102
Author(s):  
Daniel De la Iglesia-García ◽  
Wei Huang ◽  
Iria Baston-Rey ◽  
Cristina Calviño-Suarez ◽  
Jose Lariño-Noia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Pancreatitis ◽  
Meta Analysis ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency

scholarly journals A Case of Chronic Pancreatic Insufficiency Due to Valproic Acid in a Child

2001 ◽  
Vol 15 (2) ◽  
pp. 127-130 ◽  
Author(s):  
Mary Anne Cooper ◽  
Aubrey Groll
Keyword(s):  
Valproic Acid ◽  
Weight Loss ◽  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Pancreatic Insufficiency ◽  
Pancreatic Enzyme ◽  
Exocrine Pancreatic Insufficiency ◽  
Radiological Evaluation ◽  
Enzyme Replacement

A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis. The association with valproic acid was not recognized, and the child continued to take the drug. The patient eventually developed steatorrhea and weight loss that improved with pancreatic enzyme replacement. Radiological evaluation showed an atrophic pancreas. Without evidence of other etiological factors, valproic acid by itself appeared to be the cause of chronic pancreatitis with exocrine pancreatic insufficiency in this patient.

scholarly journals Acute Pancreatitis Complicated with Choledochal Duct Rupture

2011 ◽  
Vol 2011 ◽  
pp. 1-3
Author(s):  
M. Bouvry ◽  
K. Van Renterghem ◽  
A. Verrijckt ◽  
P. Smeets ◽  
V. Meersschaut ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Genetic Factors ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Rare Clinical Entity ◽  
Hereditary Pancreatitis ◽  
Recurrent Acute Pancreatitis ◽  
Ductus Choledochus ◽  
Cationic Trypsinogen ◽  
Familial Context

Recurrent acute pancreatitis is a rare clinical entity in childhood with unknown incidence (Rosendahl et al., 2007) and often occurring in a familial context. Genetic factors such as PRSS1 mutations (cationic trypsinogen gene) can be found in some patients. However, many remain idiopathic. The natural history remains poorly documented and the most frequent complications reported are pain, exocrine pancreatic insufficiency, diabetes mellitus, and pancreatic adenocarcinoma after long-standing hereditary pancreatitis. We describe a patient with hereditary pancreatitis in whom a mild pancreatitis episode was complicated by a perforation of the ductus choledochus.

scholarly journals Acute pancreatitis prevalence in children with cystic fibrosis and PIP score prediction applicability

2021 ◽  
Vol 16 (2) ◽  
pp. 248-253
Author(s):  
Valentina-Daniela COMĂNICI ◽  
◽  
Ioana Florentina CODREANU ◽  
Anca BĂLĂNESCU ◽  
Alina Angelica BELIVACĂ ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Retrospective Study ◽  
Pediatric Population ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Substitution Therapy ◽  
Imaging Evaluation ◽  
Female Predominance

One of the affected organs in cystic fibrosis (CF) is the pancreas, mainly translated into exocrine pancreatic insufficiency. Although rare, acute pancreatitis (AP) has been described, mostly in pancreatic sufficient patients. Objectives. Estimating AP prevalence in CF pediatric population of the I.N.S.M.C. „AlessandrescuRusescu” CF centre. Material and methods. 5 year retrospective study (2011-2016) including INSMC CF centre pediatric population aged 3-18 years. PA diagnosis was established on the presence of minimum 2 criteria between: characteristic abdominal pain, x3 normal value for age elevation of amylase/lipase, medical imaging evaluation suggestive for AP. Patients were evaluated with different criteria including PIP score of predicting AP risk. Outcomes. 48 patients were included with a slight female predominance (54%). 3 of them presented diagnostic criteria for AP (6,25%), all heaving pancreatic insufficiency and high PIP score (low risk of developing AP); 2 of them have low compliance with pancreatic enzymes substitution therapy; one of them presented recurrent episodes of AP. Conclusions. AP is a rare CF complication. It can be easily missed due to a large number of abdominal pain and emesis causes in CF patients. Although it is usually associated with pancreatic sufficiency, all our patients were pancreatic insufficient.

scholarly journals Pancreatic involvement in inflammatory bowel disease: a review

2019 ◽  
Vol 44 (3) ◽  
pp. 23-32
Author(s):  
F. S. Fousekis ◽  
V. I. Theopistos ◽  
K. H. Katsanos ◽  
D. K. Christodouloua
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Acute Pancreatitis ◽  
Bowel Disease ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Pancreatic Diseases ◽  
Pancreatic Involvement ◽  
Multisystemic Disease ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a multisystemic disease, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases in Crohn’s disease and ulcerative colitis is more frequent compared to the general population. Pancreatic manifestations in IBD include a wide heterogenic group of disorders and abnormalities of the pancreas and range from mild self-limited diseases to severe disorders. Acute pancreatitis, chronic pancreatitis, autoimmune pancreatitis, pancreatic autoantibodies, exocrine pancreatic insufficiency and asymptomatic imaging and laboratory abnormalities are included in related-IBD pancreatic manifestations. Involvement of the pancreas in IBD may be the result of IBD itself or of medications used.

Incidence of exocrine pancreatic insufficiency after acute pancreatitis: systemic review and meta-analysis

Pancreatology ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. S3
Author(s):  
D. de la Iglesia García ◽  
W. Huang ◽  
I. Bastón Rey ◽  
J. Lariño Noia ◽  
J. Iglesias García ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Meta Analysis ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Systemic Review

scholarly journals Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study

2018 ◽  
Vol 41 (3) ◽  
pp. 20-30
Author(s):  
J. Tu ◽  
J. Zhang ◽  
L. Ke ◽  
Y. Yang ◽  
Q. Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Acute Pancreatitis ◽  
Blood Glucose ◽  
Pancreatic Necrosis ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Long Term Follow Up

Introduction. Patients could develop endocrine and exocrine pancreatic insufficiency after acute pancreatitis (AP), but the morbidity, risk factors and outcome remain unclear. The aim of the present study was to evaluate the incidence of endocrine and exocrine pancreatic insufficiency after AP and the risk factors of endocrine pancreatic insufficiency through a long-term follow-up investigation. Methods. Follow-up assessment of the endocrine and exocrine function was conducted for the discharged patients with AP episodes. Oral Glucose Tolerance Test (OGTT) and faecal elastase-1(FE-1) test were used as primary parameters. Fasting blood-glucose (FBG), fasting insulin (FINS), glycosylated hemoglobin HBA1c, 2-h postprandial blood glucose (2hPG), Homa beta cell function index (HOMA-β), homeostasis model assessment of insulin resistance (HOMA-IR) and FE-1 were collected. Abdominal contrast-enhanced computed tomography (CECT) was performed to investigate the pancreatic morphology and the other related data during hospitalization was also collected. Results. One hundred thirteen patients were included in this study and 34 of whom (30.1%) developed diabetes mellitus (DM), 33 (29.2%) suffered impaired glucose tolerance (IGT). Moreover, 33 patients (29.2%) developed mild to moderate exocrine pancreatic insufficiency with 100μg/g<FE-1<200μg/g and 7 patients (6.2%) were diagnosed with severe exocrine pancreatic insufficiency with FE-1<100μg/g. The morbidity of DM and IGT in patients with pancreatic necrosis was significant higher than that in the non-pancreatic necrosis group (χ2 = 13.442,P = 0.001). The multiple logistic regression analysis showed that extent of pancreatic necrosis<30% (P = 0.012, OR = 0.061) were the protective factors of endocrine pancreatic insufficiency. HOMA-IR (P = 0.002, OR = 6.626), Wall-off necrosis (WON) (P = 0.013, OR = 184.772) were the risk factors. Conclusion. The integrated morbidity of DM and IGT after AP was 59.25%, which was higher than exocrine pancreatic insufficiency. 6.2% and 29.2% of patients developed severe and mild to moderate exocrine pancreatic insufficiency, respectively. The extent of pancreatic necrosis>50%, WON and insulin resistance were the independent risk factors of new onset diabetes after AP.

scholarly journals Pancreatic diseases and inflammatory bowel diseases: a random or regular combination?

2020 ◽  
Vol 92 (1) ◽  
pp. 76-81
Author(s):  
V A Akhmedov ◽  
O V Gaus
Keyword(s):  
Inflammatory Bowel Disease ◽  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
General Population ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Pancreatic Diseases ◽  
Wide Range ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Pathology of the pancreas in inflammatory bowel disease (IBD) is more common than in the general population and includes a wide range of manifestations from asymptomatic to severe disorders. Acute pancreatitis, chronic pancreatitis, autoimmune pancreatitis, exocrine pancreatic insufficiency, increased pancreatic enzymes and structural duct anomalies are often associated with IBD. They can be either a manifestation of IBD itself or develop independently.

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