Ninety-Six Hour Wireless Esophageal pH Study in Patients with GERD Shows that Restrictive Diet Reduces Esophageal Acid Exposure

2019 ◽  
Vol 65 (8) ◽  
pp. 2331-2344 ◽  
Author(s):  
George Triadafilopoulos ◽  
Julia Wilhelmina Korzilius ◽  
Thomas Zikos ◽  
Irene Sonu ◽  
Nielsen Q. Fernandez-Becker ◽  
...  
Keyword(s):  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Esophageal Ph ◽  
Restrictive Diet

scholarly journals Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hongfei Fang ◽  
Don C. Codipilly ◽  
Karthik Ravi ◽  
Dale C. Ekbom ◽  
Jan L. Kasperbauer ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Proton Pump Inhibitor Therapy ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Subglottic Stenosis ◽  
Tertiary Referral Center ◽  
Esophageal Ph ◽  
Impedance Testing

Introduction. Idiopathic subglottic stenosis represents a spectrum of subglottic disease without a clear underlying cause. Prior studies have implicated a pathogenic role of gastroesophageal reflux disease in idiopathic subglottic stenosis. The aim of this study was to examine the presence and pattern of gastroesophageal reflux in a large cohort of patients with idiopathic subglottic stenosis at a tertiary referral center. Methods. We performed a retrospective review of patients with idiopathic subglottic stenosis from January 2010 to December 2016 who had undergone combined pH impedance testing. Patients with prior gastric or esophageal surgery were excluded. Data obtained included esophageal acid exposure times, number of reflux events, patient position during reflux events (defined as upright, supine, or mixed), body mass index, and the presence of proton pump inhibitor therapy. Results. 159 patients with the idiopathic subglottic stenosis were identified, of whom 41 had undergone esophageal pH impedance testing. 40 (97.6%) were women, with a mean age of 54.8 (range 31–79) years and BMI of 31.0 (range 17–55). Overall, 19 (46.3%) patients were found to reflux as confirmed by abnormal esophageal acid exposure or abnormal number of reflux events. 15 of the 19 patients with reflux had predominantly upright gastroesophageal reflux disease, whereas 2 had supine and 2 mixed reflux. Discussion. In patients with idiopathic subglottic stenosis who underwent evaluation by combined pH impedance, close to half were found to have gastroesophageal reflux disease. The majority of gastroesophageal reflux occurred while the patients were in the upright position.

scholarly journals Gastroesophageal Reflux Type and Number Correlate with Nutritional Patterns (P06-066-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sergey Morozov ◽  
Vasily Kropochev ◽  
Vasily Isakov
Keyword(s):  
Gastroesophageal Reflux ◽  
Dietary Fiber ◽  
High Energy ◽  
Weak Acid ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Energy Value ◽  
Esophageal Ph ◽  
Medium Strength ◽  
Fiber Consumption

Abstract Objectives The correlation of nutritional patterns with number and types of gastroesophageal refluxes is poorly studied yet. Aim: To assess the effect of actual nutrition of GERD patients on the number and type of gastroesophageal reflux detected with 24-hours esophageal pH-impedance. Methods One hundred twenty-four GERD patients (54 men, age (M ± m): 46 ± 17.7 y.o., BMI 28.5 ± 0.6 kg/m2) and 41 healthy controls (8 men, age 42 ± 12.4 y.o., BMI 28.3 ± 1.3 kg/m2) were examined with the use of language-specific food frequency questionnaire and 24-hours esophageal pH-impedance (Ohmega, MMS; 2 pH, 6 impedance catheters, Unisensor). The correlation analysis between macro- and micronutrient consumption and the number of gastroesophageal refluxes (GER), their acidity and duration was performed (Statistica 10, StatSoft) Results Direct medium-strength correlation was found between esophageal acid exposure time and the energy value of the ration (Spearman rank R = 0.19, p < 0.05), and the amount of consumed fat (R = 0.2, p < 0.05). There was a direct correlation of the total number of GERs with the energy value of the ration (R = 0.35, p < 0.05), protein (R = 0.3, p < 0.05), fat (R = 0.33, p < 0.05), and alcohol consumption (R = 0.28, p < 0.05) and the inverse one with the dietary fiber consumption (R = −0.22). Significant direct correlation was found between the number of acid GERs and total energy value of the ration (R = 0.35, p < 0.05), consumption of fat (R = 0.32, p < 0.05), protein (R = 0.25, p < 0.05), carbohydrates (R = 0.24, p < 0.05) and alcohol (R = 0.24, p < 0.05). Number of weak-acid GERs showed direct correlation with the calories intake (R = 0.22, p < 0.05), fat (R = 0.21, p < 0.05), protein (R = 0.22, p < 0.05), alcohol (R = 0.23, p < 0.05) consumption, and the inverse one with the amount of dietary fiber intake (R = −0.24, p < 0.05). Number of high GERs correlated directly with the amount of fat (R = 0.3, p < 0.05), protein (R = 0.22, p < 0.05), alcohol (R = 0.25, p < 0.05) consumed, and inversely with the amount of dietary fiber (R = −0.25, p < 0.05) in the ration. Paired comparison of the correlation coefficients was performed, but didn't reveal any difference. Conclusions High energy value, consumption of fat and alcohol showed direct medium-strength correlation with esophageal acid exposure and number of GERs. Dietary fiber consumption correlated inversely with total number, weak acid and high GERs. Funding Sources Federal research Center of Nutrition and Biotechnology, Russian science foundation.

scholarly journals Impact of prolonged 48-h wireless capsule esophageal pH monitoring on diagnosis of gastroesophageal reflux disease and evaluation of the relationship between symptoms and reflux episodes

2011 ◽  
Vol 48 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Gerson Ricardo de Souza Domingues ◽  
Joaquim Prado P. Moraes-Filho ◽  
Aline Gonçalves Leite Domingues
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Diagnostic Yield ◽  
Ph Monitoring ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Esophageal Ph ◽  
Symptom Association Probability ◽  
Wireless Capsule

CONTEXT: Gastroesophageal reflux disease is one of the most common digestive diseases and an important cause of distress to patients. Diagnosis of this condition can require ambulatory pH monitoring. OBJECTIVES: To determine the diagnostic yield of a wireless ambulatory pH monitoring system of 48-hours, recording to diagnose daily variability of abnormal esophageal acid exposure and its symptom association. METHODS: A total of 100 consecutive patients with persistent reflux symptoms underwent wireless pH capsule placement from 2004 to 2009. The wireless pH capsule was deployed 5 cm proximal to the squamocolumnar junction after lower esophageal sphincter was manometrically determined. The pH recordings over 48-h were obtained after uploading data to a computer from the receiver that recorded pH signals from the wireless pH capsule. The following parameters were analyzed: (1) percentual time of distal esophageal acid exposure; (2) symptom association probability related to acid reflux. The results between the first and the second day were compared, and the diagnostic yield reached when the second day monitoring was included. RESULTS: Successful pH data over 48-h was obtained in 95% of patients. Nearly one quarter of patients experienced symptoms ranging from a foreign body sensation to chest pain. Forty-eight hours pH data analysis was statistically significant when compared to isolated analysis of day 1 and day 2. Study on day 2 identified seven patients (30.4%) that would be missed if only day 1 was analyzed. Three patients (18.7%) out of 16 patients with normal esophageal acid exposure on both days, showed positive symptom association probability, which generated an increase in diagnostic yield of 43.4%. CONCLUSION: Esophageal pH monitoring with wireless capsule is safe, well tolerated, does not require sedation. The extended 48-h period of study poses an increased yield to diagnose gastroesophageal reflux disease patients.

H. pylori (Hp), intragastric (IG) pH and esophageal acid exposure (EAE) — The GERD triangle

2001 ◽  
Vol 120 (5) ◽  
pp. A48-A48
Author(s):  
V SHARMA ◽  
C HOWDEN
Keyword(s):  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
H Pylori

Su2078 MicroRNA-Mediated Posttranscriptional Regulation At the Synapses in Rostral Cingulate Cortex Following Esophageal Acid Exposure in Rats

2013 ◽  
Vol 144 (5) ◽  
pp. S-550-S-551
Author(s):  
Banani Banerjee ◽  
Bidyut K. Medda ◽  
Soumya Pochiraju ◽  
Jyoti N. Sengupta ◽  
Reza Shaker
Keyword(s):  
Posttranscriptional Regulation ◽  
Cingulate Cortex ◽  
Esophageal Acid Exposure ◽  
Acid Exposure

Reply to letter from Sebastian F. Schoppmann et al. regarding ‘Radial esophageal acid exposure and the dilated distal esophagus’

2012 ◽  
Vol 47 (11) ◽  
pp. 1277-1278
Author(s):  
Shunji Ohara ◽  
Kenji Furuta ◽  
Kyoichi Adachi ◽  
Yoshikazu Kinoshita
Keyword(s):  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Distal Esophagus

Abnormal esophageal acid exposure is common in morbidly obese patients and improves after a successful Lap-band system implantation

2002 ◽  
Vol 16 (11) ◽  
pp. 1631-1635 ◽  
Author(s):  
P. Iovino ◽  
L. Angrisani ◽  
F. Tremolaterra ◽  
E. Nirchio ◽  
M. Ciannella ◽  
...  
Keyword(s):  
Band System ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Lap Band ◽  
Abnormal Esophageal Acid Exposure

Is normal esophageal acid exposure on pH monitoring in Barrett's patients maintained on repeated testing?

2003 ◽  
Vol 124 (4) ◽  
pp. A539 ◽  
Author(s):  
Promila Banerjee ◽  
Fawzia Ahmad ◽  
Radu Tutuian ◽  
R.M. Gideon ◽  
Donald O. Castell ◽  
...  
Keyword(s):  
Ph Monitoring ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Repeated Testing

Relation Between Esophageal Acid Exposure and Esophageal Peristalsis

2008 ◽  
Vol 53 (3) ◽  
pp. 861-861
Author(s):  
Joseph C. Yarze
Keyword(s):  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Esophageal Peristalsis
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