Histochemical examination of systemic administration of eldecalcitol combined with guided bone regeneration for bone defect restoration in rats

2016 ◽  
Vol 48 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Xiuchun Han ◽  
Juan Du ◽  
Di Liu ◽  
Hongrui Liu ◽  
Norio Amizuka ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Guided Bone Regeneration ◽  
Systemic Administration ◽  
Histochemical Examination

Guided Bone Regeneration in Calvarial Bone Defects Using Polytetrafluoroethylene Membranes

1995 ◽  
Vol 32 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Carles Bosch ◽  
Birte Melsen ◽  
Karin Vargervik
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Dura Mater ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Parietal Bone ◽  
Bony Defect ◽  
Calvarial Bone ◽  
Double Membrane ◽  
Single Membrane

Guided bone regeneration is defined as controlled stimulation of new bone formation in a bony defect, either by osteogenesis, osteoinduction, or osteoconduction, re-establishing both structural and functional characteristics. Bony defects may be found as a result of congenital anomalies, trauma, neoplasms, or infectious conditions. Such conditions are often associated with severe functional and esthetic problems. Corrective treatment is often complicated by limitations in tissue adaptations. The aim of the investigation was to compare histologically the amount of bone formed in an experimentally created parietal bone defect protected with one or two polytetrafluoroethylene membranes with a contralateral control defect. A bony defect was created bilaterally in the parietal bone lateral to the sagittal suture in 29 6-month-old male Wistar rats. The animals were divided into two groups: (1) In the double membrane group (n=9), the left experimental bone defect was protected by an outer polytetrafluoroethylene membrane under the periosteum and parietal muscles and an inner membrane between the dura mater and the parietal bone. (2) In the single membrane group (n=20), only the outer membrane was placed. The right defect was not covered with any membrane and served as control. The animals were killed after 30 days. None of the control defects demonstrated complete or partial bone regeneration. In the single membrane group, the experimental site did not regenerate in 15 animals, partially in four, and completely in one. In the double membrane group, six of the experimental defects had complete closure with bone, two had partial closure, and one no closure. The use of two membranes protecting the bone edges of the parietal defect from the overlying tissues and underlying brain enhanced bone regeneration in experimental calvarial bone defects. The biologic role of the dura mater may not be of critical importance in new bone regeneration in these calvarial bone defects.

scholarly journals Effect of Gellan Gum/Tuna Skin Film in Guided Bone Regeneration in Artificial Bone Defect in Rabbit Calvaria

Materials ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1318
Author(s):  
Seunggon Jung ◽  
Hee-Kyun Oh ◽  
Myung-Sun Kim ◽  
Ki-Young Lee ◽  
Hongju Park ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Gellan Gum ◽  
Collagen Membrane ◽  
New Bone Formation ◽  
Average Cell ◽  
Beta Tricalcium Phosphate

It is necessary to prevent the invasion of soft tissue into bone defects for successful outcomes in guided bone regeneration (GBR). For this reason, many materials are used as protective barriers to bone defects. In this study, a gellan gum/tuna skin gelatin (GEL/TSG) film was prepared, and its effectiveness in bone regeneration was evaluated. The film exhibited average cell viability in vitro. Experimental bone defects were prepared in rabbit calvaria, and a bone graft procedure with beta-tricalcium phosphate was done. The film was used as a membrane of GBR and compared with results using a commercial collagen membrane. Grafted material did not show dispersion outside of bone defects and the film did not collapse into the bone defect. New bone formation was comparable to that using the collagen membrane. These results suggest that the GEL/TSG film could be used as a membrane for GBR.

scholarly journals Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

2018 ◽  
Vol 37 (6) ◽  
pp. 912-918 ◽  
Author(s):  
Reo IKUMI ◽  
Takayuki MIYAHARA ◽  
Norio AKINO ◽  
Noriko TACHIKAWA ◽  
Shohei KASUGAI
Keyword(s):  
Lactic Acid ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Guided Bone Regeneration ◽  
Defect Model ◽  
Hydrophilic Membrane ◽  
Rat Bone

scholarly journals Evaluation of Guided Bone Regeneration Using the Bone Substitute Bio-Oss® and a Collagen Membrane in a Rat Cranial Bone Defect Model

2018 ◽  
Vol 27 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Shin Kasuya ◽  
Shihoko Inui ◽  
Nahoko Kato-Kogoe ◽  
Michi Omori ◽  
Kayoko Yamamoto ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Substitute ◽  
Guided Bone Regeneration ◽  
Cranial Bone ◽  
Collagen Membrane ◽  
Defect Model

Guided bone regeneration to repair an alveolar bone defect in a girl whose cleft lip and palate had been repaired

2005 ◽  
Vol 43 (5) ◽  
pp. 420-422 ◽  
Author(s):  
Toshitsugu Kawata ◽  
Miho Yuki ◽  
Yoshihiro Miyamoto ◽  
Tadashi Fujita ◽  
Masato Kaku ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Alveolar Bone Defect

A Synthetic Biodegradable Polymer Membrane for Guided Bone Regeneration in Bone Defect

2021 ◽  
Vol 17 (3) ◽  
pp. 456-465
Author(s):  
Kangjie Ma ◽  
Dongmei Mei ◽  
Xiaodong Lin ◽  
Li Zhang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
Bone Defect ◽  
Biodegradable Polymer ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Gbr Membrane ◽  
Alveolar Bone Defect

Guided bone regeneration (GBR) technique is most commonly used to treat alveolar bone defect. Polylactic acid (PLA) attracts much attention to utilize as a GBR membrane because it has relatively high mechanical strength and biodegradability. However, randomized controlled trials of PLA as a GBR membrane in animals were rare. The aim of this work is to observe the efficacy of polylactic acid membrane in guiding bone regeneration in Beagle canine alveolar bone defect restoration and to compare efficacy with the collagen membrane, providing an experimental basis for further clinical use of the polylactic acid membrane. The tests of physical and chemical properties showed that the PLA membrane has well mechanical strength to maintenance the space for the new bone, and has proper aperture for the attachment of osteoblasts. Through X-ray and histopathological examination of the different time points, the bone grafting material covered with PLA membrane can form similar mature bone compared to collagen membrane ones. Meanwhile, biodegradable speed of the PLA membrane was slower. Thus, this study showed that polylactic acid membrane as synthetic biodegradable polymer was reliably effective in guiding bone regeneration of alveolar bone defects, showed the favorable osteogenic capability and forecasts well applications in bone augmentation.

Haversian Remodeling in Guided Bone Regeneration with Calcium Alginate Film in Circular Bone Defect Model of Rabbit

2007 ◽  
Vol 35 (5) ◽  
pp. 533-542 ◽  
Author(s):  
Hong He ◽  
Jianqi Huang ◽  
Jiejun Shi ◽  
Feiyun Ping ◽  
Guanfu Chen ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Calcium Alginate ◽  
Guided Bone Regeneration ◽  
Defect Model
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