A Synthetic Biodegradable Polymer Membrane for Guided Bone Regeneration in Bone Defect

2021 ◽  
Vol 17 (3) ◽  
pp. 456-465
Author(s):  
Kangjie Ma ◽  
Dongmei Mei ◽  
Xiaodong Lin ◽  
Li Zhang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
Bone Defect ◽  
Biodegradable Polymer ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Gbr Membrane ◽  
Alveolar Bone Defect

Guided bone regeneration (GBR) technique is most commonly used to treat alveolar bone defect. Polylactic acid (PLA) attracts much attention to utilize as a GBR membrane because it has relatively high mechanical strength and biodegradability. However, randomized controlled trials of PLA as a GBR membrane in animals were rare. The aim of this work is to observe the efficacy of polylactic acid membrane in guiding bone regeneration in Beagle canine alveolar bone defect restoration and to compare efficacy with the collagen membrane, providing an experimental basis for further clinical use of the polylactic acid membrane. The tests of physical and chemical properties showed that the PLA membrane has well mechanical strength to maintenance the space for the new bone, and has proper aperture for the attachment of osteoblasts. Through X-ray and histopathological examination of the different time points, the bone grafting material covered with PLA membrane can form similar mature bone compared to collagen membrane ones. Meanwhile, biodegradable speed of the PLA membrane was slower. Thus, this study showed that polylactic acid membrane as synthetic biodegradable polymer was reliably effective in guiding bone regeneration of alveolar bone defects, showed the favorable osteogenic capability and forecasts well applications in bone augmentation.

Guided bone regeneration to repair an alveolar bone defect in a girl whose cleft lip and palate had been repaired

2005 ◽  
Vol 43 (5) ◽  
pp. 420-422 ◽  
Author(s):  
Toshitsugu Kawata ◽  
Miho Yuki ◽  
Yoshihiro Miyamoto ◽  
Tadashi Fujita ◽  
Masato Kaku ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Alveolar Bone Defect

scholarly journals Leucocyte- and Platelet-Rich Fibrin Block: Its Use for the Treatment of a Large Cyst with Implant-Based Rehabilitation

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 180 ◽  
Author(s):  
Rodolfo Mauceri ◽  
Denise Murgia ◽  
Orazio Cicero ◽  
Luigi Paternò ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Healing ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Critical Size ◽  
Large Bone ◽  
Alveolar Bone Defect ◽  
Positive Results ◽  
Autologous Platelet

The management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases.

Characterization of Hydrophilized PCL Electrospun Sheet as an Efective Guided Bone Regeneration Membrane

2007 ◽  
Vol 342-343 ◽  
pp. 293-296 ◽  
Author(s):  
Wan Jin Cho ◽  
Jun Ho Kim ◽  
Se Heang Oh ◽  
Jin Ho Lee
Keyword(s):  
Mechanical Strength ◽  
Bone Regeneration ◽  
High Surface ◽  
High Surface Area ◽  
Tween 80 ◽  
Guided Bone Regeneration ◽  
Selective Permeability ◽  
Polymeric Biomaterial ◽  
Water Absorbability ◽  
Gbr Membrane

Electrospinning is a fabrication process that can produce highly porous nano-scale fiber-based matrices using an electrostatically driven jet of polymer solution. This method represents an attractive approach for polymeric biomaterial processing which provides the membrane structure that may retain mechanical strengths, flexibility, and high surface area. In this study, we prepared a guided bone regeneration (GBR) membrane with selective permeability, hydrophilicity, good mechanical strength and adhesiveness with bone using polycaprolactone (PCL) and Tween 80 by the electrospinning method. The prepared PCL and PCL/Tween 80 electrospun sheets were characterized via morphology observation, mechanical property, water absorbability, and model nutrient permeability. It was observed that the PCL/Tween 80 (3 wt%) electrospun sheet have an effective permeation of nutrients as well as the good mechanical strength to maintain a secluded space for the bone regeneration. From the results, the hydrophilized PCL/Tween 80 (3 wt%) electrospun sheet seem to be a good candidate as a GBR membrane.

scholarly journals Guided Bone Regeneration- A Comprehensive Review

2021 ◽  
Author(s):  
Vineetha Venugopalan ◽  
Anegundi Raghavendra Vamsi ◽  
Santhosh Shenoy ◽  
Karishma Ashok ◽  
Biju Thomas
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Primary Stability ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Bony Defect ◽  
Graft Material ◽  
Bone Augmentation ◽  
Wide Range ◽  
Space Maintenance

Successful implant treatment requires prosthetically driven placement of an implant, primary stability at placement, and careful living bone management. The resorptive changes of alveolar bone are an inevitable process following tooth loss, periodontal disease or trauma which causes bone defects. This results in various aesthetic and functional complications such as soft tissue recession, infection and inflammation. Various methods have been tried and advocated for augmenting these bone deficiencies. Guided Bone Regeneration (GBR) is a successful modality for bone augmentation with a wide range of indications and helps restore the alveolar ridge dimensions. It utilises the principle of Guided Tissue Regeneration (GTR) for space maintenance within a bony defect. Different types of barrier membranes are being utilised along with various bone grafts in GBR. Thorough knowledge regarding the biology of bone is required before the initiation of any bone augmentation procedure. A combination of Collagen Membrane (CM) and graft material was found successful for GBR. Hence, this review focuses on presentation of best available evidence for various aspects of GBR.

scholarly journals Predifferentiated Gingival Stem Cell-Induced Bone Regeneration in Rat Alveolar Bone Defect Model

2020 ◽  
Author(s):  
Umadevi Kandalam ◽  
Toshihisa Kawai ◽  
Geeta Ravindran ◽  
Ross Brockman ◽  
Jorge Romero ◽  
...  
Keyword(s):  
Stem Cell ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Defect Model ◽  
Alveolar Bone Defect

scholarly journals Effect of Gellan Gum/Tuna Skin Film in Guided Bone Regeneration in Artificial Bone Defect in Rabbit Calvaria

Materials ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1318
Author(s):  
Seunggon Jung ◽  
Hee-Kyun Oh ◽  
Myung-Sun Kim ◽  
Ki-Young Lee ◽  
Hongju Park ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Gellan Gum ◽  
Collagen Membrane ◽  
New Bone Formation ◽  
Average Cell ◽  
Beta Tricalcium Phosphate

It is necessary to prevent the invasion of soft tissue into bone defects for successful outcomes in guided bone regeneration (GBR). For this reason, many materials are used as protective barriers to bone defects. In this study, a gellan gum/tuna skin gelatin (GEL/TSG) film was prepared, and its effectiveness in bone regeneration was evaluated. The film exhibited average cell viability in vitro. Experimental bone defects were prepared in rabbit calvaria, and a bone graft procedure with beta-tricalcium phosphate was done. The film was used as a membrane of GBR and compared with results using a commercial collagen membrane. Grafted material did not show dispersion outside of bone defects and the film did not collapse into the bone defect. New bone formation was comparable to that using the collagen membrane. These results suggest that the GEL/TSG film could be used as a membrane for GBR.

scholarly journals Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model

2022 ◽  
Vol 23 (1) ◽  
pp. 558
Author(s):  
Chih-Hsiang Fang ◽  
Chung-Kai Sun ◽  
Yi-Wen Lin ◽  
Min-Chih Hung ◽  
Hung-Ying Lin ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Critical Size ◽  
Lower Percentage ◽  
Type I ◽  
Defect Model ◽  
Good Biocompatibility ◽  
Alveolar Bone Defect

In this study, we fabricated gelatin/nano-hydroxyapatite/metformin scaffold (GHMS) and compared its effectiveness in bone regeneration with extraction-only, Sinbone, and Bio-Oss Collagen® groups in a critical size rat alveolar bone defect model. GHMS was synthesized by co-precipitating calcium hydroxide and orthophosphoric acid within gelatin solution, incorporating metformin, and cross-linked by microbial transglutaminase. The morphology, characterization, and biocompatibility of scaffold were examined. The in vitro effects of GHMS on osteogenic gene and protein expressions were evaluated. In vivo bone formation was assessed in a critical size rat alveolar bone defect model with micro-computed tomography and histological examination by comparing GHMS with extraction-only, Sinbone, and Bio-Oss Collagen®. The synthesized GHMS had a highly interconnected porous structure with a mean pore size of 81.85 ± 13.8 µm. GHMS exhibited good biocompatibility; promoted ALPL, RUNX2, SP7, BGLAP, SPARC and Col1a1 gene expressions; and upregulated the synthesis of osteogenic proteins, including osteonectin, osteocalcin, and collagen type I. In critical size rat alveolar bone defects, GHMS showed superior bone regeneration compared to extraction-only, Sinbone, and Bio-Oss Collagen® groups as manifested by greater alveolar ridge preservation, while more bone formation with a lower percentage of connective tissue and residual scaffold at the defect sites grafted with GHMS in histological staining. The GHMS presented in this study may be used as a potential bone substitute to regenerate alveolar bone. The good biocompatibility, relatively fast degradation, interconnected pores allowing vascularization, and higher bioactivity properties of the components of the GHMS (gelatin, nHA, and metformin) may contribute to direct osteogenesis.

scholarly journals Evaluation of Guided Bone Regeneration Using the Bone Substitute Bio-Oss® and a Collagen Membrane in a Rat Cranial Bone Defect Model

2018 ◽  
Vol 27 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Shin Kasuya ◽  
Shihoko Inui ◽  
Nahoko Kato-Kogoe ◽  
Michi Omori ◽  
Kayoko Yamamoto ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Substitute ◽  
Guided Bone Regeneration ◽  
Cranial Bone ◽  
Collagen Membrane ◽  
Defect Model

scholarly journals A novel lamellar structural biomaterial and its effect on bone regeneration

RSC Advances ◽  
2020 ◽  
Vol 10 (64) ◽  
pp. 39072-39079
Author(s):  
Guoping Cheng ◽  
Shujuan Guo ◽  
Ningxin Wang ◽  
Shimeng Xiao ◽  
Bo Jiang ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Ctenopharyngodon Idella ◽  
Collagen Membrane ◽  
High Mechanical Strength ◽  
Enzyme Degradation ◽  
Degradation Ability

To evaluate a novel lamellar structural biomaterial for guided bone regeneration, we describe the preparation of a collagen membrane with high mechanical strength and anti-enzyme degradation ability using Ctenopharyngodon idella scales.

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