Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells

Inflammation ◽

10.1007/s10753-017-0516-6 ◽

2017 ◽

Vol 40 (3) ◽

pp. 725-734 ◽

Author(s):

Ji Tu ◽

Wentian Li ◽

Yukun Zhang ◽

Xinghuo Wu ◽

Yu Song ◽

...

Keyword(s):

Extracellular Matrix ◽

Nucleus Pulposus ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation ◽

Mapk Pathways ◽

Induced Apoptosis

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Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo

International Immunopharmacology ◽

10.1016/j.intimp.2019.01.004 ◽

2019 ◽

Vol 69 ◽

pp. 398-407 ◽

Author(s):

Ke Wang ◽

Tingting Chen ◽

Xiaozhou Ying ◽

Zengjie Zhang ◽

Zhenxuan Shao ◽

...

Keyword(s):

Extracellular Matrix ◽

Intervertebral Disc ◽

Nucleus Pulposus ◽

Disc Degeneration ◽

Intervertebral Disc Degeneration ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation ◽

Induced Apoptosis

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Inhibition of microRNA-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating SOX9

Chemico-Biological Interactions ◽

10.1016/j.cbi.2018.09.010 ◽

2018 ◽

Vol 296 ◽

pp. 89-97 ◽

Author(s):

Junlin Lv ◽

Siyuan Li ◽

Tingting Wan ◽

Yimeng Yang ◽

Yali Cheng ◽

...

Keyword(s):

Extracellular Matrix ◽

Nucleus Pulposus ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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RhTSG-6 inhibits IL-1β-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells

Folia Histochemica et Cytobiologica ◽

10.5603/fhc.a2020.0019 ◽

2020 ◽

Vol 58 (3) ◽

pp. 227-234

Author(s):

Shishen Pei ◽

Jinwei Ying ◽

Yan Zhang ◽

Linhao Su ◽

Shi Cheng ◽

...

Keyword(s):

Extracellular Matrix ◽

Nucleus Pulposus ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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Irigenin reduces the expression of caspase-3 and matrix metalloproteinases, thus suppressing apoptosis and extracellular matrix degradation in TNF-α-stimulated nucleus pulposus cells

Chemico-Biological Interactions ◽

10.1016/j.cbi.2021.109681 ◽

2021 ◽

pp. 109681

Author(s):

Gaofeng Zhang ◽

Yuanmei Liao ◽

Hanshi Yang ◽

Jian Tao ◽

Lin Ma ◽

...

Keyword(s):

Extracellular Matrix ◽

Matrix Metalloproteinases ◽

Nucleus Pulposus ◽

Caspase 3 ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation ◽

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Berberine prevents human nucleus pulposus cells from IL‑1β‑induced extracellular matrix degradation and apoptosis by inhibiting the NF‑κB pathway

International Journal of Molecular Medicine ◽

10.3892/ijmm.2019.4105 ◽

2019 ◽

Author(s):

Lin Lu ◽

Jialang Hu ◽

Qipeng Wu ◽

Ying An ◽

Wei Cui ◽

...

Keyword(s):

Extracellular Matrix ◽

Nucleus Pulposus ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2021.02.129 ◽

2021 ◽

Vol 550 ◽

pp. 30-36

Author(s):

Wang Ding ◽

Yuxiang Ge ◽

Huiyi Sun ◽

Jun Xu ◽

Huijie Gu ◽

...

Keyword(s):

Extracellular Matrix ◽

Signaling Pathway ◽

Nucleus Pulposus ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL‑1β‑induced extracellular matrix degradation

10.1080/15384101.2021.1911914 ◽

2021 ◽

pp. 1-18

Author(s):

Kaiqiang Sun ◽

Jian Zhu ◽

Jingchuan Sun ◽

Xiaofei Sun ◽

Le Huan ◽

...

Keyword(s):

Extracellular Matrix ◽

Neuropeptide Y ◽

Nucleus Pulposus ◽

Cell Apoptosis ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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MicroRNA-15b silencing inhibits IL-1β-induced extracellular matrix degradation by targeting SMAD3 in human nucleus pulposus cells

Biotechnology Letters ◽

10.1007/s10529-016-2280-3 ◽

2016 ◽

Vol 39 (4) ◽

pp. 623-632 ◽

Author(s):

Liang Kang ◽

Cao Yang ◽

Huipeng Yin ◽

Kangcheng Zhao ◽

Wei Liu ◽

...

Keyword(s):

Extracellular Matrix ◽

Nucleus Pulposus ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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Marein protects human nucleus pulposus cells against high glucose-induced injury and extracellular matrix degradation at least partly by inhibition of ROS/NF-κB pathway

International Immunopharmacology ◽

10.1016/j.intimp.2019.106126 ◽

2020 ◽

Vol 80 ◽

pp. 106126 ◽

Author(s):

Mingyan Yao ◽

Jing Zhang ◽

Zhihong Li ◽

Shuqin Guo ◽

Xue Zhou ◽

...

Keyword(s):

Extracellular Matrix ◽

Nucleus Pulposus ◽

High Glucose ◽

Matrix Degradation ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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MiR-423-5P Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells

Medical Science Monitor ◽

10.12659/msm.922497 ◽

2020 ◽

Vol 26 ◽

Author(s):

Hanrong Xu ◽

Liefeng Ji ◽

Chunhua Yu ◽

Qiming Chen ◽

Qiangqiang Ge ◽

...

Keyword(s):

Extracellular Matrix ◽

Nucleus Pulposus ◽

Interleukin 1 ◽

Nucleotide Binding ◽

Interleukin 1 Beta ◽

Matrix Degradation ◽

Leucine Rich Repeat ◽

Nucleus Pulposus Cells ◽

Extracellular Matrix Degradation

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