The assessment of peripapillary retinal nerve fiber layer and macular ganglion cell layer changes in obese children: a cross-sectional study using optical coherence tomography

2016 ◽  
Vol 37 (4) ◽  
pp. 1031-1038 ◽  
Author(s):  
Omer Karti ◽  
Ozlem Nalbantoglu ◽  
Saygin Abali ◽  
Selma Tunc ◽  
Behzat Ozkan
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Obese Children ◽  
Fiber Layer ◽  
Cross Sectional

scholarly journals Investigation of the pathophysiology of the retina and choroid in Parkinson's disease by optical coherence tomography

2021 ◽  
Author(s):  
Yasuaki Kamata ◽  
Naoto Hara ◽  
Tsukasa Satou ◽  
Takahiro Niida ◽  
Kazuo Mukuno
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Luminal Area

Abstract Purpose The pathology of Parkinson's disease (PD) is suspected to affect the retina and choroid. We investigated changes in the retina and choroid of patients with PD using optical coherence tomography. Methods We examined 14 patients with PD and 22 patients without PD. Patients without PD had no ophthalmic disease other than cataracts. In addition, it was also confirmed that there was no neurodegenerative disease. The retinal nerve fiber layer, ganglion cell layer + inner plexiform layer, and choroidal thickness were compared between both groups. Additionally, the choroidal image was divided into the choroid area, luminal area, and interstitial area using the binarization method, and the area of each region and the percentage of luminal area in the choroid area were analyzed. Results Patients with PD had a significantly thinner ganglion cell layer + inner plexiform layer compared to those without PD. The choroid area, luminal area, and interstitial area were significantly decreased in patients with PD compared to those without PD. Seven patients with PD who were successfully followed up showed decreased retinal nerve fiber layer and interstitial area after 3 years. Conclusion Autonomic nervous disorders and neurodegeneration in PD can cause thinning of the retina and choroid, as well as a reduction in the choroid area.

scholarly journals Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using optical coherence tomography

2020 ◽  
Author(s):  
Panitha Jindahra ◽  
Nitchanan Hengsiri ◽  
Pirada Witoonpanich ◽  
Anuchit Poonyathalang ◽  
Teeratorn Pulkes ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean

Abstract Background: To evaluate the feasibility of using optical coherence tomography (OCT) for the detection of Alzheimer's disease (AD), by measuring the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell layer and inner plexiform layer (GCL-IPL).Methods: This was a single-center, cross-sectional study. The study included 29 patients with AD (mean age ± standard deviation: 75.61 ± 6.24 years) and 29 healthy age- and sex-matched controls. All participants underwent cognitive evaluations using the Montreal Cognitive Assessment test. Measurements of the RNFL thickness, as well as GCL-IPL thickness, were obtained for all participants using OCT. Both RNFL and GCL-IPL parameters were adjusted for best–corrected visual acuity.Results: The mean RNFL thickness was significantly thinner in the AD group than in the control group (85.24 and 90.68 µm, respectively, adjusted P = 0.019). The superior quadrant was thinner in the AD group (adjusted P = 0.042). The thicknesses did not differ significantly between groups for the other quadrants. The mean GCL-IPL thickness in the AD (68.81 µm) was significantly thinner than that in the controls (76.42 µm) (adjusted P = 0.010). Overall, there was a negative correlation between age and mean RNFL; and between age and GCL-IPL thickness (r = − 0.338, P = 0.010 and r = − 0.346, P = 0.008, respectively).Conclusions: The mean RNFL and GCL-IPL thicknesses were thinner in the AD group than in the control group. These findings suggest that RNFL and GCL-IPL thickness may be biological markers for AD.

Investigation of the Pathophysiology of the Retina and Choroid in Parkinson's Disease by Optical Coherence Tomography

2021 ◽  
Author(s):  
Yasuaki Kamata ◽  
Naoto Hara ◽  
Tsukasa Satou ◽  
Takahiro Niida ◽  
Kazuo Mukuno
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Luminal Area

Abstract PurposeThe pathology of Parkinson's disease (PD) is suspected to affect the retina and choroid. We investigated changes in the retina and choroid of patients with PD using optical coherence tomography (OCT).MethodsWe examined 14 patients with PD and 22 patients without PD. Patients without PD had no ophthalmic pathology other than cataracts and neurodegenerative disorders. The retinal nerve fiber layer, ganglion cell layer + inner plexiform layer, and choroidal thickness were compared between both groups. Additionally, the choroidal image was divided into the choroid area, luminal area, and interstitial area using the binarization method, and the area of each region and the percentage of luminal area in the choroid area was analyzed. ResultsPatients with PD had a significantly thinner ganglion cell layer + inner plexiform layer compared to those without PD. The choroid area, luminal area, and interstitial area were significantly decreased in patients with PD compared to those without PD. Seven patients with PD who were successfully followed-up for 3 years showed decreased retinal nerve fiber layer and interstitial area after 3 years.ConclusionAutonomic nervous disorders and neurodegeneration in PD can cause thinning of the retina and choroid, as well as a reduction of the choroid area.

scholarly journals Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography

2020 ◽  
Vol Volume 14 ◽  
pp. 2995-3000
Author(s):  
Panitha Jindahra ◽  
Nitchanan Hengsiri ◽  
Pirada Witoonpanich ◽  
Anuchit Poonyathalang ◽  
Teeratorn Pulkes ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer
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