Choroidal thickness changes determined by EDI-OCT on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis

Purpose. To assess the state of the choroid in patients with HLA-B27-associated anterior uveitis without detectable lesions of the macular zone by ophthalmoscopy. Material and methods. 22 patients with HLA-B27-associated acute anterior uveitis without detectable changes in the macular zone by ophthalmoscopy – the main group. Age: 39.02±13.76 years, men – 16 and women – 8. Best corrected visual acuity varied from 0.1 to 0.5 (average 0.3). The level of intraocular pressure according to Maklakov in all eyes varied from 15 to 22 mm Hg. The parameters of paired intact eyes of patients served as a control. The subfoveal choroid thickness (CT) was determined using optical coherence tomography in comparison with paired intact eyes before treatment and 2 weeks after its initiation. Results. The initial values of the CT indexes in the main group varied from 337 to 371 μm, averaging 354±8 μm. This is statistically significantly higher than in intact paired eyes 255±7 μm (from 246 to 268 μm), p <0.001. 2 weeks after the start of treatment CT indexes in the main group were 268±10 μm, which was statistically significantly lower than the initial indexes in this group, p<0.001. In paired eyes, they were 254±6 μm. Conclusion. A statistically significant increase in CT was revealed in the eyes of patients with acute anterior uveitis, which statistically significantly exceeded the values of the paired intact eye on average on 100 μm. 2 weeks after the start of treatment, the CT indexes statistically significantly decreased to 268±10 μm, which did not differ statistically significantly from the CT indexes of the intact eye. Key words: anterior uveitis, HLA-B27, choroidal thickness.

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The Association between Ankylosing Spondylitis, Acute Anterior Uveitis and HLA-B27: The Results of a Swiss Family Study

Rheumatology ◽

10.1093/rheumatology/xxvii.suppl_2.39 ◽

1988 ◽

Vol XXVII (suppl 2) ◽

pp. 39-41 ◽

Cited By ~ 17

Author(s):

S. M. van der Linden ◽

H. U. Rentsch ◽

N. Gerber ◽

A. Cats ◽

H. A. Valkenburg

Keyword(s):

Ankylosing Spondylitis ◽

Anterior Uveitis ◽

Family Study ◽

Hla B27 ◽

Acute Anterior Uveitis

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Humoral Immune Response to Klebsiella Capsular Polysaccharides in HLA-B27-Positive Patients with Acute Anterior Uveitis and Ankylosing Spondylitis

Autoimmunity ◽

10.3109/08916939808995368 ◽

1998 ◽

Vol 28 (4) ◽

pp. 209-215 ◽

Cited By ~ 9

Author(s):

H. Sahly ◽

R. Podschun ◽

Jörn Kekow ◽

Berngard Nölle ◽

Wolfgang L. Gross ◽

...

Keyword(s):

Immune Response ◽

Ankylosing Spondylitis ◽

Humoral Immune Response ◽

Anterior Uveitis ◽

Capsular Polysaccharides ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Humoral Immune

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SAT0233 Acute Anterior Uveitis in Ankylosing Spondylitis: Association with Inflammatory Bowel Disease and Psoriasis Independent of HLA-B27

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.4375 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 743.1-743

Author(s):

A. Omar ◽

T. Boyd ◽

I. Sari ◽

A. Thavaneswaran ◽

R. Ayearst ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Ankylosing Spondylitis ◽

Anterior Uveitis ◽

Bowel Disease ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Inflammatory Bowel

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Morphometric assessment of the state of the choroid in patients with anterior uveitis associated with the HLA-B27 Antigen

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-1-172-175 ◽

2021 ◽

pp. 172-175

Author(s):

E.V. Udovichenko ◽

◽

E.L. Sorokin ◽

L.P. Danilova ◽

◽

...

Keyword(s):

Anterior Uveitis ◽

Choroidal Thickness ◽

Main Group ◽

The State ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Initial Values ◽

Corrected Visual Acuity ◽

Morphometric Assessment ◽

Optical Coherence Tomograph

Purpose. To assess the state of the choroid in patients with anterior uveitis associated with the HLA-B27 Antigen, without ophthalmoscopically detectable lesions of the macular zone. Material and methods. 24 patients with acute anterior uveitis associated with HLA-B27 Antigen, without ophthalmologically detectable changes in the macular zone. The average age of the patients was 39.02±13.76 years. There were 16 men and 8 women. Maximum corrected visual acuity ranged from 0.1 to 0.5. The level of intraocular pressure according to Maklakov varied from 15 to 22 mm Hg. The subfoveal choroidal thickness (SCT) was determined using an optical coherence tomograph in comparison with paired intact eyes before treatment and 2 weeks after its initiation. Results. The initial values of the SCT index in the main group varied from 337 to 371 µm, averaging 354±8 µm. This is statistically significantly higher than in intact paired eyes (255±7 µm; from 246 to 268 µm; p<0.001). 2 weeks after the start of treatment, the SCT index in the main group was 268±10 µm, which was statistically significantly lower than the initial values in this group (p<0.001). Conclusion. A statistically significant increase in SCT was revealed in the eyes of patients with acute anterior uveitis. 2 weeks after the start of treatment, the SCT index statistically significantly decreased to 268±10 µm, which did not statistically significantly differ from that of the intact eye. Key words:anterior uveitis, HLA-B27 Antigen, subfoveolar thickness of the choroid.

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The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B27 positive juvenile and adult Mexican subjects with ankylosing spondylitis

Annals of the Rheumatic Diseases ◽

10.1136/ard.56.8.488 ◽

1997 ◽

Vol 56 (8) ◽

pp. 488-492 ◽

Cited By ~ 30

Author(s):

W. P Maksymowych ◽

G. S Jhangri ◽

C. Gorodezky ◽

M. Luong ◽

C. Wong ◽

...

Keyword(s):

Ankylosing Spondylitis ◽

Anterior Uveitis ◽

Hla B27 ◽

Acute Anterior Uveitis

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Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2016-309499 ◽

2017 ◽

Vol 102 (2) ◽

pp. 215-219 ◽

Cited By ~ 22

Author(s):

Peizeng Yang ◽

Wenjuan Wan ◽

Liping Du ◽

Qingyun Zhou ◽

Jian Qi ◽

...

Keyword(s):

Ankylosing Spondylitis ◽

Clinical Features ◽

Anterior Uveitis ◽

Human Leucocyte Antigen ◽

Visual Outcome ◽

Secondary Glaucoma ◽

Vascular Involvement ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Complicated Cataract

AimsTo characterise the clinical features of human leucocyte antigen (HLA)-B27+acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients.MethodsA total of 1056 HLA-B27+ AAU patients (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients were divided into human leucocyte antigen (HLA)-B27+AS+ and HLA-B27+AS− group. Clinical features including the onset of uveitis, laterality, the age at first attack, clinical examinations, best corrected visual acuity (BCVA), abnormalities in fundus fluorescence angiography (FFA) and complications were determined and compared between these two groups.ResultsThere were 581 (55.0%) and 475 (45.0%) patients respectively classified into HLA-B27+AS+ and HLA-B27+AS− group. Males had a higher prevalence than females in the HLA-B27+AS+ group (75.2%) as compared with the HLA-B27+AS− group (51.8%, p<0.001). The HLA-B27+AS+ patients showed a higher percentage of bilateral/alternating involvement (47.3%) as compared with the HLA-B27+AS− group (36.6%, p=0.001). A higher percentage of fibrinous exudation, synechiae as well as complications including complicated cataract and secondary glaucoma were found in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group. Worse visual outcome as indicated by a higher percentage of patients with BCVA <0.5 and with BCVA <0.05 was noted in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group both before and after treatment. FFA showed mild capillary fluorescence leakage in the late phase with indistinctly defined margins on the peripheral retina in 39.3% of HLA-B27+ AAU patients. There was no difference concerning the retinal vascular involvement between these two groups.ConclusionsOur study confirmed that HLA-B27+AS+ patients show a higher percentage of males, more common bilateral involvement, a higher frequency of fibrinous exudates, synechiae and secondary glaucoma as compared with HLA-B27+AS− patients. Visual outcome was poorer, possibly due to the higher prevalence of complicated cataract in HLA-B27+AS+ patients. Retinal vascular involvement was not uncommon in HLA-B27+ AAU patients.

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