Morphometric assessment of the state of the choroid in patients with anterior uveitis associated with the HLA-B27 Antigen

Purpose. To assess the state of the choroid in patients with anterior uveitis associated with the HLA-B27 Antigen, without ophthalmoscopically detectable lesions of the macular zone. Material and methods. 24 patients with acute anterior uveitis associated with HLA-B27 Antigen, without ophthalmologically detectable changes in the macular zone. The average age of the patients was 39.02±13.76 years. There were 16 men and 8 women. Maximum corrected visual acuity ranged from 0.1 to 0.5. The level of intraocular pressure according to Maklakov varied from 15 to 22 mm Hg. The subfoveal choroidal thickness (SCT) was determined using an optical coherence tomograph in comparison with paired intact eyes before treatment and 2 weeks after its initiation. Results. The initial values of the SCT index in the main group varied from 337 to 371 µm, averaging 354±8 µm. This is statistically significantly higher than in intact paired eyes (255±7 µm; from 246 to 268 µm; p<0.001). 2 weeks after the start of treatment, the SCT index in the main group was 268±10 µm, which was statistically significantly lower than the initial values in this group (p<0.001). Conclusion. A statistically significant increase in SCT was revealed in the eyes of patients with acute anterior uveitis. 2 weeks after the start of treatment, the SCT index statistically significantly decreased to 268±10 µm, which did not statistically significantly differ from that of the intact eye. Key words:anterior uveitis, HLA-B27 Antigen, subfoveolar thickness of the choroid.

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Dynamics choroidal thickness in anterior uveitis without visible retinal changes

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-2-204-207 ◽

2021 ◽

pp. 204-207

Author(s):

E.V. Udovichenko ◽

◽

E.L. Sorokin ◽

L.P. Danilova ◽

◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Intraocular Pressure ◽

Anterior Uveitis ◽

Choroidal Thickness ◽

Main Group ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Corrected Visual Acuity ◽

Best Corrected Visual Acuity

Purpose. To assess the state of the choroid in patients with HLA-B27-associated anterior uveitis without detectable lesions of the macular zone by ophthalmoscopy. Material and methods. 22 patients with HLA-B27-associated acute anterior uveitis without detectable changes in the macular zone by ophthalmoscopy – the main group. Age: 39.02±13.76 years, men – 16 and women – 8. Best corrected visual acuity varied from 0.1 to 0.5 (average 0.3). The level of intraocular pressure according to Maklakov in all eyes varied from 15 to 22 mm Hg. The parameters of paired intact eyes of patients served as a control. The subfoveal choroid thickness (CT) was determined using optical coherence tomography in comparison with paired intact eyes before treatment and 2 weeks after its initiation. Results. The initial values of the CT indexes in the main group varied from 337 to 371 μm, averaging 354±8 μm. This is statistically significantly higher than in intact paired eyes 255±7 μm (from 246 to 268 μm), p <0.001. 2 weeks after the start of treatment CT indexes in the main group were 268±10 μm, which was statistically significantly lower than the initial indexes in this group, p<0.001. In paired eyes, they were 254±6 μm. Conclusion. A statistically significant increase in CT was revealed in the eyes of patients with acute anterior uveitis, which statistically significantly exceeded the values of the paired intact eye on average on 100 μm. 2 weeks after the start of treatment, the CT indexes statistically significantly decreased to 268±10 μm, which did not differ statistically significantly from the CT indexes of the intact eye. Key words: anterior uveitis, HLA-B27, choroidal thickness.

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Choroidal thickness changes determined by EDI-OCT on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis

International Ophthalmology ◽

10.1007/s10792-017-0464-z ◽

2017 ◽

Cited By ~ 6

Author(s):

Berna Basarir ◽

Ugur Celik ◽

Cigdem Altan ◽

Nimet Burcu Celik

Keyword(s):

Ankylosing Spondylitis ◽

Anterior Uveitis ◽

Choroidal Thickness ◽

Hla B27 ◽

Acute Anterior Uveitis

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HLA-B27 frequency in Greek patients with acute anterior uveitis.

British Journal of Ophthalmology ◽

10.1136/bjo.61.11.699 ◽

1977 ◽

Vol 61 (11) ◽

pp. 699-701 ◽

Cited By ~ 15

Author(s):

J Zervas ◽

G Tsokos ◽

G Papadakis ◽

E Kabouklis ◽

D Papadopoulos

Keyword(s):

Anterior Uveitis ◽

Hla B27 ◽

Acute Anterior Uveitis

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Serum Levels of β2-Microglobulin in HLA-B27+Patients with Acute Anterior Uveitis and Ankylosing Spondylitis

Scandinavian Journal of Rheumatology ◽

10.3109/03009749009097068 ◽

1990 ◽

Vol 19 (sup87) ◽

pp. 104-107 ◽

Cited By ~ 2

Author(s):

M. F. C. Beersma ◽

P. J. F. M. Derhaag ◽

T. E. W. Feltkamp

Keyword(s):

Ankylosing Spondylitis ◽

Anterior Uveitis ◽

Serum Levels ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Β2 Microglobulin

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Is a positive family history of spondyloarthritis relevant for diagnosing axial spondyloarthritis once HLA-B27 status is known?

Rheumatology ◽

10.1093/rheumatology/kez095 ◽

2019 ◽

Vol 58 (9) ◽

pp. 1649-1654 ◽

Cited By ~ 7

Author(s):

Miranda van Lunteren ◽

Désirée van der Heijde ◽

Alexandre Sepriano ◽

Inger J Berg ◽

Maxime Dougados ◽

...

Keyword(s):

Back Pain ◽

Family History ◽

Anterior Uveitis ◽

Chronic Back Pain ◽

Axial Spondyloarthritis ◽

Positive Family History ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Negative Results ◽

History Of

Abstract Objectives A positive family history (PFH) of spondyloarthritis, in particular a PFH of AS or acute anterior uveitis, is associated with HLA-B27 carriership in chronic back pain patients. As it is unknown, the study aimed to investigate if a PFH contributes to diagnosing axial spondyloarthritis (axSpA) once HLA-B27 status is known. Methods In axSpA-suspected patients from the Assessment of SpondyloArthritis international Society (ASAS), DEvenir des Spondyloarthropathies Indifférenciéés Récentes (DESIR) and SPondyloArthritis Caught Early (SPACE) cohorts, logistic regression analyses were performed with HLA-B27 status and PFH according to the ASAS definition (ASAS-PFH) as determinants and clinical axSpA diagnosis as outcome at baseline. Analyses were repeated with a PFH of AS or acute anterior uveitis. Results In total, 1818 patients suspected of axSpA were analysed (ASAS n = 594, DESIR n = 647, and SPACE n = 577). In patients from the ASAS, DESIR and SPACE cohorts, respectively 23%, 39% and 38% had an ASAS-PFH, 52%, 58% and 43% were HLA-B27 positive, and 62%, 47% and 54% were diagnosed with axSpA. HLA-B27 was independently associated with an axSpA diagnosis in each cohort but an ASAS-PFH was not [ASAS cohort: HLA-B27 odds ratio (OR): 6.9 (95% CI: 4.7, 10.2), ASAS-PFH OR: 0.9 (95% CI: 0.6, 1.4); DESIR: HLA-B27 OR: 2.1 (95% CI: 1.5, 2.9), ASAS-PFH OR: 1.0 (95% CI 0.7, 1.3); SPACE: HLA-B27 OR: 10.4 (95% CI: 6.9, 15.7), ASAS-PFH OR: 1.0 (95% CI: 0.7, 1.5)]. Similar negative results were found for PFH of AS and acute anterior uveitis. Conclusion In three independent cohorts with different ethnical backgrounds, ASAS, DESIR and SPACE, a PFH was not associated independently of HLA-B27 with a diagnosis of axSpA. This indicates that in the vast majority of patients presenting with back pain, a PFH does not contribute to the likelihood of an axSpA diagnosis if HLA-B27 status is known.

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