Subfoveal choroidal thickness changes after intravitreal ranibizumab injections in different patterns of diabetic macular edema using a deep learning-based auto-segmentation

Aim. To investigate the change in subfoveal choroidal thickness (SFCT) in vitrectomized eyes with intravitreal dexamethasone (IVD) implant injection for the treatment of diabetic macular edema (DME). Method. In this prospective and controlled study, the vitrectomized eyes of diabetic patients were included. The study group (Group 1) was formed by diabetic vitrectomized eyes with DME. The control group (Group 2) was formed by diabetic vitrectomized eyes without DME. Only one intravitreal IVD implant was injected into the eyes in Group 1. In the first, second, and fourth months, choroidal layers were measured by optical coherence tomography and complete ophthalmologic examinations were performed for all cases. Results. Ninety-six eyes of 96 cases were included in the study. There were 48 eyes of 48 different patients in each group. After IVD injection, statistically significant improvement was observed in the best corrected visual acuity in Group 1. The mean SFCT in eyes with DME was statistically significantly thinner ( p < 0.01) and thinness became more pronounced during the four-month follow-up period after IVD implant injection ( p < 0.01). Conclusion. In the presence of DME in vitrectomized eyes, the thinness of the SFCT may become evident after dexamethasone implant injection.

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Changes in subfoveal choroidal thickness in diabetic macular edema

Egyptian Retina Journal ◽

10.4103/erj.erj_14_16 ◽

2017 ◽

Vol 4 (1) ◽

pp. 1

Author(s):

HaithamYounis Al-Nashar

Keyword(s):

Macular Edema ◽

Diabetic Macular Edema ◽

Choroidal Thickness ◽

Subfoveal Choroidal Thickness

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Comparison of subfoveal choroidal thickness in eyes with CRVO and BRVO

10.21203/rs.2.429/v1 ◽

2019 ◽

Author(s):

Fen Tang ◽

Fan Xu ◽

Haibin Zhong ◽

Xin Zhao ◽

Mingliang Lv ◽

...

Keyword(s):

Macular Edema ◽

Choroidal Thickness ◽

Case Series ◽

T Test ◽

Intravitreal Ranibizumab ◽

Subfoveal Choroidal Thickness ◽

Significant Difference ◽

Treatment Naïve ◽

Paired T Test ◽

Fellow Eyes

Abstract Backgroud: To evaluate the subfoveal choroidal thickness (SFCT) in eyes with macular edema secondary to retinal vein occlusion（RVO），and to investigate the short-term response after a single intravitreal Ranibizumab injection. What is more, to compare the SFCT and SFCT change in eyes with central RVO (CRVO) and branch RVO (BRVO). Methods: The observational case series had collected treatment-naïve patients with unilateral macular edema secondary to RVO retrospectively (19 CRVO and 17 BRVO). They had received at least one intravitreal ranibizumab (IVR) injection after newly diagnosed. The SFCT values before IVR and after 2 weeks of IVR were collected and analyzed. Paired t test was performed to compare the difference between RVO eye and its unaffected fellow eye, and to compare the SFCT change between before IVR and after 2 weeks of IVR. In further, the SFCT and SFCT change in eyes with CRVO and BRVO were also evaluated with independent t test. Results: Mean SFCT in CRVO eyes at the onset was 326.03±30.86 μm, which was significantly greater than that in contralateral fellow eyes (p<0.01, paired t test), and decreased to 294.15±30.83 μm rapidly after 2 weeks of IVR (p<0.01, paired t test). Similarly, the SFCT in BRVO eyes was significant thicker than its contralateral eyes at the onset, and reduced after IVR. However, our findings showed that there was no significant difference on the SFCT at the onset and SFCT change after IVR between CRVO eyes and BRVO eyes. Conclusions: The SFCT in eyes with macular edema secondary to RVO (CRVO or BRVO,respectively) was significantly greater than that in fellow eyes, and decreased significantly within a short time in response to a single IVR injection. It indicated choroid was involved in the progress of macular edema secondary to RVO. Our study collected recent-onset and treatment- naïve patients, it may help to elucidate the conflicting results of SFCT in RVO eyes reported by previous studies. In further, the study first showed that the SFCT may have no relationship with RVO subtypes. However, further study is need to investigate the exact relationship between SFCT and RVO subtypes.

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