Determination of analgesics in pharmaceutical formulations and urine samples using nano polypyrrole modified glassy carbon electrode

2009 ◽  
Vol 39 (8) ◽  
pp. 1177-1184 ◽  
Author(s):  
B. Muralidharan ◽  
G. Gopu ◽  
C. Vedhi ◽  
P. Manisankar
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Pharmaceutical Formulations ◽  
Urine Samples ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode

Voltammetric Determination of Guaifenesin in Pharmaceuticals and Urine Samples Based on Poly(Bromocresol Purple) Modified Glassy Carbon Electrode

2020 ◽  
Vol 16 (5) ◽  
pp. 633-639
Author(s):  
Fatma Ağın
Keyword(s):  
Differential Pulse Voltammetry ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Urine Samples ◽  
Bromocresol Purple ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Pulse Voltammetry

Introduction: The electro-oxidation behavior of expectorant drug Guaifenesin (GUF) was studied on poly(bromocresol purple) modified Glassy Carbon Electrode (GCE) by Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) methods. Materials and Methods: GCE was modified with electropolymerization of Bromocresol Purple (BP) monomer for sensitive determination of GUF with voltammetric methods. The oxidation process of GUF showed irreversible and diffusion controlled behavior. The linearity has been obtained in the range from 1.00 × 10-7 to 2.00 × 10-5 M with the limit of detection 3.658 × 10-9 M for DPV in 0.1 M phosphate buffer solution (PBS) at pH 3.0. Results and Conclusion: Fully validated differential pulse voltammetry was successfully applied for the determination of GUF in pharmaceutical dosage forms and urine samples obtained satisfying results.

Sign in / Sign up

Export Citation Format

Share Document