Multiple sclerosis is a chronic inflammatory and demyelinating disorder of the central
nervous system (CNS) that can cause cognition, mobility, and sensory impairments. Studies have
shown that the immune system through inflammation and autoreactive T cells are involved in the
progression of MS. The present article aimed to review the potent anti-inflammatory, antioxidant,
and immunomodulatory agents that could modulate the immune response in MS. In herbal
medicine, various medicinal plants including Olive, Silybum marianum, Grape, Pomegranate peel
extract, Nigella sativa, Turmeric, Green tea, Aloysia citrodora, Boswellia papyrifera, Boswellia serrata,
Ruta graveolens, and Andrographis paniculata are known with therapeutic benefits in MS patients
through immunoregulation and reduction of major symptoms.