Factors affecting assisted reproductive technology (ART) pregnancy rates: a multivariate analysis

Relevance. Effectiveness of assisted reproductive technology (ART) programs is quite high, but for couples who have already had failed attempts of ART programs the likelihood of getting pregnant decreases with each subsequent attempt. Low endometrial thickness is a common cause of a decline in a possibility of getting pregnant. However, data on predictive value of this index in ART programs are contradictory. Some researchers do not find a correlation between the endometrium thickness and ART programs outcomes. Other researchers revealed a statistically significant relationship between endometrium thickness and pregnancy rate in ART cycles. Aim. To evaluate an effect of “thin” endometrium on pregnancy rate in ART programs. Materials and methods. 154 couples who applied for infertility treatment in ART programs were included in this prospective study. The patients were stratified into groups depending on whether a pregnancy to occur: Group 1 (n=43) - pregnancy occurred and Group 2 (n=111) - pregnancy did not occur. Then the endometrial thickness threshold determining pregnancy occurrence was identified by ultrasound and two additional groups were formed: Group 3 (n=85) - patients with “thin” endometrium, Group 4 (n=69) - patients with normal endometrial thickness. Results. The endometrial thickness threshold at which pregnancy probability, as well as the model and area under the curve (AUC) reliability were maximum, was 8.0 mm (AUC=86.7%, sensitivity - 97.7%, specificity - 75.7%). The adjusted odds ratio of pregnancy occurrence depending on endometrial thickness given the excellent quality blastocysts obtained, was 9.1 (95% confidence interval 4.3-19.3). Factors affecting endometrial thickness were endometrial polyps with polypectomy and spontaneous miscarriages in anamnesis that was undoubtedly associated with an inflammatory genesis of endometrial damage Conclusions. "Thin" endometrium plays a negative role in ART programs reducing pregnancy likelihood by 9.1 times.

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Factors affecting birthweight of singletons from assisted reproductive technology

Fertility and Sterility ◽

10.1016/j.fertnstert.2015.07.683 ◽

2015 ◽

Vol 104 (3) ◽

pp. e217

Author(s):

S. Daneshmand ◽

F. Garner ◽

M. Aguirre ◽

C. Hudson ◽

B.S. Shapiro

Keyword(s):

Assisted Reproductive Technology ◽

Reproductive Technology ◽

Factors Affecting

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Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates

International Journal of Molecular Sciences ◽

10.3390/ijms21249688 ◽

2020 ◽

Vol 21 (24) ◽

pp. 9688

Author(s):

Toshiko Minamoto ◽

Kentaro Nakayama ◽

Tomoka Ishibashi ◽

Masako Ishikawa ◽

Kohei Nakamura ◽

...

Keyword(s):

Telomere Length ◽

Assisted Reproductive Technology ◽

Multivariate Regression ◽

Single Copy ◽

Reproductive Technology ◽

Clinical Factors ◽

Factors Affecting ◽

Lifestyle Related Diseases ◽

The Relationship ◽

Multiple Conditions

Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not known. In this study, we sought to identify factors that influence fetal TL. A total of 578 mother-newborn pairs were included for TL analysis. TL was measured in genomic DNA extracted from cord blood samples using quantitative PCR. The clinical factors examined at enrollment included the following intrauterine environmental factors: maternal age, assisted reproductive technology (ART) used, body mass index (BMI), gestational diabetes mellitus (GDM), maternal stress, smoking, alcohol consumption, preterm delivery, small-for-gestational-age, neonatal sex, and placental weight. Univariate and multivariate regression analyses were used to verify the relationship between neonatal TL and these clinical factors. The median neonatal TL to single-copy gene ratio was 1.0. Pregnancy with ART was among the 11 factors associated with shorter neonatal TL. From multiple regression analysis, we determined that neonatal TL was significantly shorter for pregnancies in the ART group than in the other groups. We conclude that pregnancy with ART is associated with shorter neonatal TL.

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