A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist

2006 ◽  
Vol 20 (7-8) ◽  
pp. 471-493 ◽  
Author(s):  
Nidhi Singh ◽  
Gwénaël Chevé ◽  
David M. Ferguson ◽  
Christopher R. McCurdy
Keyword(s):  
Drug Design ◽  
G Protein ◽  
Opioid Receptor ◽  
Receptor Agonist ◽  
Kappa Opioid Receptor ◽  
G Protein Coupled Receptors ◽  
Salvinorin A ◽  
Kappa Opioid ◽  
Opioid Receptor Agonist ◽  
G Protein Coupled

scholarly journals A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist

FEBS Journal ◽  
2006 ◽  
Vol 273 (9) ◽  
pp. 1966-1974 ◽  
Author(s):  
Brian E. Kane ◽  
Marcelo J. Nieto ◽  
Christopher R. McCurdy ◽  
David M. Ferguson
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Kappa Opioid Receptor ◽  
Salvinorin A ◽  
Kappa Opioid ◽  
Opioid Receptor Agonist ◽  
Binding Epitope

Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist

2006 ◽  
Vol 83 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Christopher R. McCurdy ◽  
Kenneth J. Sufka ◽  
Grant H. Smith ◽  
Jason E. Warnick ◽  
Marcelo J. Nieto
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Kappa Opioid Receptor ◽  
Salvinorin A ◽  
Kappa Opioid ◽  
Opioid Receptor Agonist

Bioisosteric Modification of Salvinorin A, a Potent and Selective Kappa-Opioid Receptor Agonist

2011 ◽  
Vol 56 (04) ◽  
pp. 269-275
Author(s):  
D. Stewart ◽  
Hesham Fahmy ◽  
Bryan Roth ◽  
Feng Yan ◽  
Jordan Zjawiony
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Kappa Opioid Receptor ◽  
Salvinorin A ◽  
Kappa Opioid ◽  
Opioid Receptor Agonist
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