Investigation on dielectric properties of iron oxide nanoparticles-embedded binary transition metals-doped polyaniline-metal hybrid nanocomposites

Author(s):  
C. Anju ◽  
Shiny Palatty
2018 ◽  
Vol 36 (1) ◽  
pp. 123-133 ◽  
Author(s):  
D. Siva Kumar ◽  
K. Chandra Babu Naidu ◽  
M. Mohamed Rafi ◽  
K. Prem Nazeer ◽  
A. Ayisha Begam ◽  
...  

Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have been synthesized using co-precipitation method. Their microstructure and dielectric properties were studied. The sugar solutions like glucose, fructose and sucrose were used as stabilizers to control the size of the SPIONs. The crystal structure and grain size of the particles were determined by X-ray diffraction. The magnetic studies of the samples were carried out using the vibrating sample magnetometer and their surface morphology was studied by HRTEM, FE-SEM and zeta potential. The dielectric properties of glucose-SPIONs (GF), fructose-SPIONs (FF) and sucrose-SPIONs (SF) were investigated in the frequency range of 10 Hz to 5 MHz at selected temperatures. The FF showed a high dielectric constant of 62 at 1 MHz and the dielectric properties of SPIONs were found to have been significantly improved, especially in the low frequency regime according to the Maxwell-Wagner interfacial polarization. The AC conductivity measurements revealed that the electrical conduction depends on both frequency and temperature. Impedance analysis was carried out using Cole-Cole plot and the conduction mechanism of the studied compounds was explained. R and C values were further calculated using RC-circuit.


2015 ◽  
Vol 18 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Ta-I Yang ◽  
Chun-Yu Chuang ◽  
Shu-Chian Yang ◽  
Leo C. Kempel ◽  
Peter Kofinas

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.


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