Toho-1 β-lactamase: backbone chemical shift assignments and changes in dynamics upon binding with avibactam

2021 ◽  
Author(s):  
Varun V. Sakhrani ◽  
Rittik K. Ghosh ◽  
Eduardo Hilario ◽  
Kevin L. Weiss ◽  
Leighton Coates ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Chemical Shift Assignments ◽  
Backbone Chemical Shift

1H, 13C, and 15N backbone chemical shift assignments of StAR-related lipid transfer domain protein 5 (STARD5)

2012 ◽  
Vol 7 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Aurélien Lorin ◽  
Danny Létourneau ◽  
Andrée Lefebvre ◽  
Jean-Guy LeHoux ◽  
Pierre Lavigne
Keyword(s):  
Chemical Shift ◽  
Chemical Shift Assignments ◽  
Lipid Transfer ◽  
Backbone Chemical Shift ◽  
Domain Protein

scholarly journals Backbone chemical shift assignments of mouse HOXA13 DNA binding domain bound to duplex DNA

2010 ◽  
Vol 4 (1) ◽  
pp. 97-99 ◽  
Author(s):  
Yonghong Zhang ◽  
Chelsea K. Thornburg ◽  
H. Scott Stadler ◽  
James B. Ames
Keyword(s):  
Chemical Shift ◽  
Dna Binding ◽  
Binding Domain ◽  
Duplex Dna ◽  
Dna Binding Domain ◽  
Chemical Shift Assignments ◽  
Backbone Chemical Shift

scholarly journals 1H, 13C, and 15N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein

2020 ◽  
Author(s):  
Sophie M. Korn ◽  
Roderick Lambertz ◽  
Boris Fürtig ◽  
Martin Hengesbach ◽  
Frank Löhr ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Nucleocapsid Protein ◽  
Rna Binding ◽  
Drug Binding ◽  
Chemical Shift Assignments ◽  
Binding Studies ◽  
Dimerization Domain ◽  
N Protein ◽  
Intrinsically Disordered ◽  
Backbone Chemical Shift

AbstractThe current outbreak of the highly infectious COVID-19 respiratory disease is caused by the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). To fight the pandemic, the search for promising viral drug targets has become a cross-border common goal of the international biomedical research community. Within the international Covid19-NMR consortium, scientists support drug development against SARS-CoV-2 by providing publicly available NMR data on viral proteins and RNAs. The coronavirus nucleocapsid protein (N protein) is an RNA-binding protein involved in viral transcription and replication. Its primary function is the packaging of the viral RNA genome. The highly conserved architecture of the coronavirus N protein consists of an N-terminal RNA-binding domain (NTD), followed by an intrinsically disordered Serine/Arginine (SR)-rich linker and a C-terminal dimerization domain (CTD). Besides its involvement in oligomerization, the CTD of the N protein (N-CTD) is also able to bind to nucleic acids by itself, independent of the NTD. Here, we report the near-complete NMR backbone chemical shift assignments of the SARS-CoV-2 N-CTD to provide the basis for downstream applications, in particular site-resolved drug binding studies.

scholarly journals Backbone chemical shift assignments and secondary structure analysis of the U1 protein from the Bas-Congo virus

2016 ◽  
Vol 11 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Garry W. Buchko ◽  
Matthew C. Clifton ◽  
Ellen G. Wallace ◽  
Kateri A. Atkins ◽  
Peter J. Myler
Keyword(s):  
Chemical Shift ◽  
Secondary Structure ◽  
Structure Analysis ◽  
Chemical Shift Assignments ◽  
Secondary Structure Analysis ◽  
Backbone Chemical Shift

scholarly journals 1H, 13C and 15N backbone chemical shift assignments of camelid single-domain antibodies against active state µ-opioid receptor

2017 ◽  
Vol 11 (1) ◽  
pp. 117-121 ◽  
Author(s):  
Remy Sounier ◽  
Yinshan Yang ◽  
Joanna Hagelberger ◽  
Sébastien Granier ◽  
Hélène Déméné
Keyword(s):  
Chemical Shift ◽  
Opioid Receptor ◽  
Active State ◽  
Single Domain ◽  
Chemical Shift Assignments ◽  
Backbone Chemical Shift ◽  
Single Domain Antibodies
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