scholarly journals Transduction of Primary Lymphocytes with Epstein-Barr Virus (EBV) Latent Membrane Protein-Specific T-Cell Receptor Induces Lysis of Virus-Infected Cells: A Novel Strategy for the Treatment of Hodgkin's Disease and Nasopharyngeal Carcinoma

2006 ◽  
Vol 26 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Lisa A. Jurgens ◽  
Rajiv Khanna ◽  
James Weber ◽  
Rimas J. Orentas
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Membrane Protein ◽  
T Cell Receptor ◽  
Epstein Barr Virus ◽  
Cell Receptor ◽  
Latent Membrane Protein ◽  
Barr Virus ◽  
Infected Cells ◽  
Epstein Barr ◽  
Novel Strategy

scholarly journals The Epstein-Barr Virus Protein, Latent Membrane Protein 2A, Co-opts Tyrosine Kinases Used by the T Cell Receptor

2005 ◽  
Vol 280 (40) ◽  
pp. 34133-34142 ◽  
Author(s):  
Robert J. Ingham ◽  
Judith Raaijmakers ◽  
Caesar S. H. Lim ◽  
Geraldine Mbamalu ◽  
Gerald Gish ◽  
...  
Keyword(s):  
Membrane Protein ◽  
T Cell Receptor ◽  
Tyrosine Kinases ◽  
Epstein Barr Virus ◽  
Cell Receptor ◽  
Latent Membrane Protein ◽  
Virus Protein ◽  
Latent Membrane Protein 2A ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Modulation of the tumor microenvironment by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma

2018 ◽  
Vol 109 (2) ◽  
pp. 272-278 ◽  
Author(s):  
Tomokazu Yoshizaki ◽  
Satoru Kondo ◽  
Kazuhira Endo ◽  
Yosuke Nakanishi ◽  
Mitsuharu Aga ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Microenvironment ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

scholarly journals Cytotoxic T Cell Adoptive Immunotherapy as a Treatment for Nasopharyngeal Carcinoma

2013 ◽  
Vol 21 (2) ◽  
pp. 256-259 ◽  
Author(s):  
Viviana P. Lutzky ◽  
Pauline Crooks ◽  
Leanne Morrison ◽  
Natasha Stevens ◽  
Joanne E. Davis ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Membrane Protein ◽  
Cytotoxic T Lymphocytes ◽  
Adoptive Immunotherapy ◽  
Epstein Barr Virus ◽  
Latent Membrane Protein ◽  
Cytotoxic T Cell ◽  
Pulmonary Lesions ◽  
Barr Virus ◽  
Epstein Barr

ABSTRACTEpstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). We assess the safety and tolerability of adoptive transfer of autologous cytotoxic T lymphocytes (CTLs) specific for the EBV latent membrane protein (LMP) in a patient with recurrent NPC. After infusion, the majority of pulmonary lesions were no longer evident, although the primary tumor did not regress.

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