Indirect casting of patient-specific tricalcium phosphate zirconia scaffolds for bone tissue regeneration using rapid prototyping methodology

The review article focuses on Rapid Prototyped assisted scaffold fabrication for bone tissue regeneration, particularly in respect of its mechanical properties and cell culture abilities. The distinct feature of computer aided design and computer aided manufacturing (CAD & CAM), imaging technology and rapid prototyping (RP) technology has been used by different researchers to print porous scaffolds with requisite shape and interconnected channels for osseous tissue formation. This study concludes that the use of RP in scaffold manufacturing offers patient specific designed scaffolds with improved strength, in-vitro and in-vivo cell culture capability unlike traditional scaffold fabrication techniques. Tissue engineering using 3D Printing is a viable substitute for organ transplant, which requires willing donors to part with their organs. This study reviewed the benefits of RP/imaging/CAD-CAM to develop scaffolds for bone tissue regeneration and it serves those patients who could not be accurately treated by traditional means. The article is helpful to study the influence of RP in the field of organ transplant

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Three-Dimensional Hierarchical Composite Scaffolds Consisting of Polycaprolactone, β-Tricalcium Phosphate, and Collagen Nanofibers: Fabrication, Physical Properties, and In Vitro Cell Activity for Bone Tissue Regeneration

Biomacromolecules ◽

10.1021/bm1013052 ◽

2011 ◽

Vol 12 (2) ◽

pp. 502-510 ◽

Cited By ~ 89

Author(s):

MyungGu Yeo ◽

Hyeongjin Lee ◽

GeunHyung Kim

Keyword(s):

Physical Properties ◽

Bone Tissue ◽

Tissue Regeneration ◽

Tricalcium Phosphate ◽

Cell Activity ◽

Three Dimensional ◽

Bone Tissue Regeneration ◽

Composite Scaffolds

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2F31 In vitro study on collagen/tricalcium phosphate composite scaffolds for bone tissue regeneration

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME ◽

10.1299/jsmebio.2014.26.497 ◽

2014 ◽

Vol 2014.26 (0) ◽

pp. 497-498

Author(s):

Takaaki ARAHIRA ◽

Mitsugu TODO

Keyword(s):

Bone Tissue ◽

Tissue Regeneration ◽

Tricalcium Phosphate ◽

In Vitro Study ◽

Vitro Study ◽

Bone Tissue Regeneration ◽

Composite Scaffolds

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Hybrid Tricalcium Phosphate/Hydrogel Constructs Functionalized with an Antitumor Drug for Bone Tissue Regeneration

Inorganic Materials Applied Research ◽

10.1134/s2075113320050160 ◽

2020 ◽

Vol 11 (5) ◽

pp. 1144-1152

Author(s):

P. A. Karalkin ◽

N. S. Sergeyeva ◽

I. K. Sviridova ◽

V. A. Kirsanova ◽

S. A. Akhmedova ◽

...

Keyword(s):

Bone Tissue ◽

Tissue Regeneration ◽

Tricalcium Phosphate ◽

Antitumor Drug ◽

Bone Tissue Regeneration

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Apatite Foam Fabrication Based on Hydrothermal Reaction of α-Tricalcium Phosphate Foam

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.319 ◽

2007 ◽

Vol 361-363 ◽

pp. 319-322 ◽

Cited By ~ 5

Author(s):

Ishikawa Kunio ◽

Satoshi Karashima ◽

Akari Takeuchi ◽

Shigeki Matsuya

Keyword(s):

Pore Size ◽

Bone Tissue ◽

Tissue Regeneration ◽

Tricalcium Phosphate ◽

Hydrothermal Reaction ◽

Bone Substitutes ◽

Tissue Response ◽

Bone Tissue Regeneration ◽

Setting Reaction ◽

Interconnected Pores

Apatite foam (AP foam) is an ideal material for bone substitutes and scaffolds in bone tissue regeneration. This is because its highly porous interconnected pores provide the space for cell growth and tissue penetration, and that its composition induces excellent tissue response and good osteoconductivity. In the present study, the feasibility of apatite foam fabrication was evaluated based on so-called dissolution-reprecipitation reaction of α-tricalcium phosphate (α-TCP) foam granules. When α-TCP foam granules were placed in water at 37°C for 24h, no reaction was observed. However, α-TCP foam set to form AP foam when treated hydrothermally at 200°C. The network of fully interconnected pores was retained, and porosity was as high as 82%. Pore size ranged from 50 to 300 0m with average pore size at 160 0m. Compressive strength was 207 kPa. Although no setting reaction was observed at 37°C, setting reaction caused by hydrothermal treatment of α-TCP foam granules at 200°C allows AP foam of any shape to be fabricated. Therefore, this method was suggested to be useful for the fabrication of bone substitutes and the scaffold in bone tissue regeneration.

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