scholarly journals Rapid Prototyping Assisted Scaffold Fabrication for Bone Tissue Regeneration

2016 ◽  
Vol 5 (4) ◽  
pp. 79 ◽  
Author(s):  
Pranav S. Sapkal ◽  
Shraddha Jaiswal ◽  
Abhaykumar M. Kuthe
Keyword(s):  
Cell Culture ◽  
Rapid Prototyping ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Computer Aided Design ◽  
Organ Transplant ◽  
Bone Tissue Regeneration ◽  
Patient Specific ◽  
Scaffold Fabrication ◽  
Computer Aided

<p class="1Body">The review article focuses on Rapid Prototyped assisted scaffold fabrication for bone tissue regeneration, particularly in respect of its mechanical properties and cell culture abilities. The distinct feature of computer aided design and computer aided manufacturing (CAD &amp; CAM), imaging technology and rapid prototyping (RP) technology has been used by different researchers to print porous scaffolds with requisite shape and interconnected channels for osseous tissue formation. This study concludes that the use of RP in scaffold manufacturing offers patient specific designed scaffolds<strong> </strong>with improved strength, in-vitro and in-vivo cell culture capability unlike traditional scaffold fabrication techniques. Tissue engineering using 3D Printing is a viable substitute for organ transplant, which<strong> </strong>requires willing donors to part with their organs. This study reviewed the benefits of RP/imaging/CAD-CAM to develop scaffolds for bone<strong> </strong>tissue regeneration and it serves those patients who could not be accurately treated by traditional means. The article is helpful to study the influence of RP in the field of organ transplant</p>

Indirect casting of patient-specific tricalcium phosphate zirconia scaffolds for bone tissue regeneration using rapid prototyping methodology

2016 ◽  
Vol 24 (4) ◽  
pp. 1013-1023 ◽  
Author(s):  
Pranav S. Sapkal ◽  
Abhaykumar M. Kuthe ◽  
Rajpal S. Kashyap ◽  
Amit R. Nayak ◽  
Sudhanshu A. Kuthe ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Tricalcium Phosphate ◽  
Bone Tissue Regeneration ◽  
Patient Specific

Rapid prototyping assisted fabrication of patient specific β-tricalciumphosphate scaffolds for bone tissue regeneration

2016 ◽  
Vol 23 (4) ◽  
pp. 927-935 ◽  
Author(s):  
Pranav S. Sapkal ◽  
Abhaykumar M. Kuthe ◽  
Rajpal S. Kashyap ◽  
Amit R. Nayak ◽  
Sudhanshu A. Kuthe ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Patient Specific

Bone tissue engineering in the greater omentum with computer-aided design/computer-aided manufacturing scaffolds is enhanced by a periosteum transplant

2020 ◽  
Author(s):  
Hendrik Naujokat ◽  
Klaas Loger ◽  
Juliane Schulz ◽  
Yahya Açil ◽  
Jörg Wiltfang
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Computer Aided Design ◽  
Bone Tissue Regeneration ◽  
Histological Evaluation ◽  
Greater Omentum ◽  
Collagen Membrane ◽  
Computer Aided ◽  
3D Printed ◽  
The Impact

Aim: This study aimed to evaluate two different vascularized bone flap scaffolds and the impact of two barrier membranes for the reconstruction of critical-size bone defects. Materials & methods: 3D-printed scaffolds of biodegradable calcium phosphate and bioinert titanium were loaded with rhBMP-2 bone marrow aspirate, wrapped by a collagen membrane or a periosteum transplant and implanted into the greater omentum of miniature pigs. Results: Histological evaluation demonstrated significant bone formation within the first 8 weeks in both scaffolds. The periosteum transplant led to enhanced bone formation and a homogenous distribution in the scaffolds. The omentum tissue grew out a robust vascular supply. Conclusion: Endocultivation using 3D-printed scaffolds in the greater omentum is a very promising approach in defect-specific bone tissue regeneration.

A new hybrid scaffold using rapid prototyping and electrohydrodynamic direct writing for bone tissue regeneration

2011 ◽  
Vol 21 (47) ◽  
pp. 19138 ◽  
Author(s):  
Geun Hyung Kim ◽  
Seung Hyun Ahn ◽  
Hyeong Jin Lee ◽  
SuYeon Lee ◽  
Youngseok Cho ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Direct Writing ◽  
Hybrid Scaffold

Production of new 3D scaffolds for bone tissue regeneration by rapid prototyping

2016 ◽  
Vol 27 (4) ◽  
Author(s):  
R. Fradique ◽  
T. R. Correia ◽  
S. P. Miguel ◽  
K. D. de Sá ◽  
D. R. Figueira ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
3D Scaffolds

Lactoferrin in Bone Tissue Regeneration

2020 ◽  
Vol 27 (6) ◽  
pp. 838-853 ◽  
Author(s):  
Madalina Icriverzi ◽  
Valentina Dinca ◽  
Magdalena Moisei ◽  
Robert W. Evans ◽  
Mihaela Trif ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Cells ◽  
Bone Diseases ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Bone Tissue Regeneration ◽  
Bone Homeostasis ◽  
Active Compounds

: Among the multiple properties exhibited by lactoferrin (Lf), its involvement in bone regeneration processes is of great interest at the present time. A series of in vitro and in vivo studies have revealed the ability of Lf to promote survival, proliferation and differentiation of osteoblast cells and to inhibit bone resorption mediated by osteoclasts. Although the mechanism underlying the action of Lf in bone cells is still not fully elucidated, it has been shown that its mode of action leading to the survival of osteoblasts is complemented by its mitogenic effect. Activation of several signalling pathways and gene expression, in an LRPdependent or independent manner, has been identified. Unlike the effects on osteoblasts, the action on osteoclasts is different, with Lf leading to a total arrest of osteoclastogenesis. : Due to the positive effect of Lf on osteoblasts, the potential use of Lf alone or in combination with different biologically active compounds in bone tissue regeneration and the treatment of bone diseases is of great interest. Since the bioavailability of Lf in vivo is poor, a nanotechnology- based strategy to improve the biological properties of Lf was developed. The investigated formulations include incorporation of Lf into collagen membranes, gelatin hydrogel, liposomes, loading onto nanofibers, porous microspheres, or coating onto silica/titan based implants. Lf has also been coupled with other biologically active compounds such as biomimetic hydroxyapatite, in order to improve the efficacy of biomaterials used in the regulation of bone homeostasis. : This review aims to provide an up-to-date review of research on the involvement of Lf in bone growth and healing and on its use as a potential therapeutic factor in bone tissue regeneration.

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