LncRNAs (long non-coding RNAs) are endogenous molecules lacking protein-encoding capacity,
which have been identified as key regulators of ischemic stroke. Increasing evidence suggests that lncRNAs play
critical roles in several aspects of ischemic stroke, including atherosclerosis, dyslipidemia, hypertension, and
diabetes mellitus. Hence, lncRNAs may further broaden our understanding of stroke pathogenesis. Altered
lncRNA expression has been found in rodent focal cerebral ischemia models and oxygen–glucose deprived mouse
brain microvascular endothelial cells as well as stroke patients. LncRNAs are considered to be promising biomarkers
for the diagnosis and prognosis of cerebral ischemia. Here, we have reviewed the latest advances in
lncRNA-based therapeutic approaches for ischemic disease. Accordingly, we summarize the current understanding
of lncRNAs and ischemic stroke, focusing on the regulatory role of lncRNAs in ischemic stroke, as well as
their potential as biomarkers and therapeutic targets in cerebral ischemia.
Long Non-coding RNAs as Promising Therapeutic Approach in Ischemic Stroke: a Comprehensive Review