Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-κB in prostate cancer cells

2009 ◽  
Vol 37 (4) ◽  
pp. 1849-1855 ◽  
Author(s):  
Jin Ming Di ◽  
Jun Pang ◽  
Qi Peng Sun ◽  
Yan Zhang ◽  
You Qiang Fang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Toll Like Receptor ◽  
Prostate Cancer Cells

279: Inhibition of Cyclooxygenase-2 Pathway Overcomes the Heat-Resistance in Prostate Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 93-93
Author(s):  
Makoto Sumitomo ◽  
Kenji Kuroda ◽  
Takako Asano ◽  
Akio Horiguchi ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Resistance ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells

scholarly journals Cyclooxygenase-2 inhibitor celecoxib augments chemotherapeutic drug-induced apoptosis by enhancing activation of caspase-3 and -9 in prostate cancer cells

2005 ◽  
Vol 115 (3) ◽  
pp. 484-492 ◽  
Author(s):  
Devendra S. Dandekar ◽  
Monica Lopez ◽  
Robert I. Carey ◽  
Bal L. Lokeshwar
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Cyclooxygenase 2 ◽  
Chemotherapeutic Drug ◽  
Prostate Cancer Cells ◽  
Drug Induced ◽  
Induced Apoptosis

scholarly journals The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells

2021 ◽  
Author(s):  
Merve Nur İNCE ◽  
Asuman DEVECİ ÖZKAN ◽  
Erhan BEZDEGÜMELİ ◽  
Ahmet Yasir MEN ◽  
Bilge Nur KÜÇÜKAKÇA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Toll Like Receptor ◽  
Prostate Cancer Cells

Toll-like receptor 4 ligation confers chemoresistance to docetaxel on PC-3 human prostate cancer cells

2012 ◽  
Vol 28 (4) ◽  
pp. 269-277 ◽  
Author(s):  
Yuntao Zhang ◽  
Yong Wang ◽  
Jianlin Yuan ◽  
Weijun Qin ◽  
Fei Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Toll Like Receptor ◽  
Prostate Cancer Cells ◽  
Toll Like Receptor 4

scholarly journals Effect of endothelin-1 on cyclooxygenase-2 expression in human hormone refractory prostate cancer cells

2010 ◽  
Vol 1 (3) ◽  
pp. 495-499 ◽  
Author(s):  
QI SU ◽  
RUI-PENG JIA ◽  
JIANZHONG LIN ◽  
LU-WEI XU ◽  
ZI-ZHENG WANG ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Hormone Refractory Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Endothelin 1 ◽  
Hormone Refractory

LncRNA PART1 modulates toll-like receptor pathways to influence cell proliferation and apoptosis in prostate cancer cells

2018 ◽  
Vol 399 (4) ◽  
pp. 387-395 ◽  
Author(s):  
Ming Sun ◽  
Donghua Geng ◽  
Shuqiang Li ◽  
Zhaofu Chen ◽  
Wenyan Zhao
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Tunel Staining ◽  
Toll Like Receptor ◽  
Prostate Cancer Cells ◽  
Chain Reactions ◽  
Polymerase Chain Reactions ◽  
Qrt Pcr ◽  
Proliferation And Apoptosis

AbstractWe investigated thoroughly the effect of lncRNA PART1 on prostate cancer cells proliferation and apoptosis, through regulating toll-like receptor (TLR) pathways. LncRNA PART1 expression was also examined by quantitative real-time polymerase chain reactions (qRT-PCR) in human tissues and the cells lines LNCaP and PC3. After transfection with si-PART1 or control constructs, the cell viability was measured by MTS and colony formation assays. In addition, the apoptosis rate of the prostate cancer cells was validated by TUNEL staining. Relationships between lncRNA PART1 expression and TLR pathway genes were demonstrated by qRT-PCR and Western blotting. High levels of lncRNA PART1 expression were correlated with advanced cancer stage and predication of poor survival. LncRNA PART1 levels was increased in PCa cells treated with 5α-dihydrotestosterone (DHT), confirming PART1 was directly induced by androgen. Moreover, down-regulation of lncRNA PART1 inhibited prostate cancer cell proliferation and accelerated cell apoptosis. In addition, lncRNA PART1 induced downstream genes expression in TLR pathways includingTLR3,TNFSF10andCXCL13to further influence prostate cancer cells, indicating its carcinogenesis on prostate cancer. LncRNA PART1 promoted cell proliferation ability and apoptosis via the inhibition of TLR pathways in prostate cancer. LncRNA PART1 could hence be considered as a new target in the treatment of prostate cancer.

scholarly journals Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells

2011 ◽  
Vol 12 (1) ◽  
pp. 29 ◽  
Author(s):  
Xiaodong Wen ◽  
Celia Chao ◽  
Kirk Ives ◽  
Mark R Hellmich
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells

Radiation-Induced Cyclooxygenase 2 Up-Regulation is Dependent on Redox Status in Prostate Cancer Cells

2003 ◽  
Vol 160 (6) ◽  
pp. 617-621 ◽  
Author(s):  
Lingyun Li ◽  
Kirsten K. Steinauer ◽  
Amie J. Dirks ◽  
Bryan Husbeck ◽  
Iris Gibbs ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Redox Status ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells ◽  
Radiation Induced

scholarly journals The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2

2000 ◽  
Vol 275 (15) ◽  
pp. 11397-11403 ◽  
Author(s):  
Ao-Lin Hsu ◽  
Tsui-Ting Ching ◽  
Da-Sheng Wang ◽  
Xueqin Song ◽  
Vivek M. Rangnekar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Akt Activation
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