TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

Diabetic Patients ◽

Tcf7l2 Gene ◽

Significant Difference ◽

Patient Groups ◽

Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition with various genetics and environmental influences that affects the capacity of the body to produce or use insulin resulting in hyperglycemia, which may lead to variable complications. It is one of the world’s rising health problems. There is emerging evidence that some genetic polymorphisms can impact the risk of evolving T2DM. We try to determine the relationship of (rs7903146) variant of the Transcription factor 7-like 2 (TCF7L2) gene with T2DM and its microvascular complications.Methods and Results: This case-control study included 180 subjects: 60 diabetic patients without complications, 60 diabetic patients with microvascular complications and 60 matched healthy controls. Genotypes of rs7903146 (C/T) SNP in the TCF7L2 gene were evaluated by real-time polymerase chain reaction via TaqMan allelic discrimination. Logistic regression was used to detect the most independent factor for development of diabetes and diabetic microvascular complications. Variant homozygous TT and heterozygous TC genotypes were significantly increased in diabetic without complications and diabetic with complications groups than controls (p=0.003, 0.001) respectively. The T allele was more represented in both patient groups than controls with no significant difference between patient groups. TT genotype as well as T allele was significantly associated with increased T2DM risk.Conclusion: The T allele of rs7903146 polymorphism of TCF7L2 confers susceptibility to development of T2DM. However, no significant association was found for diabetic complications.

Association Between Serum Fibrinogen Levels and Diabetic Microvascular Complications in Type 2 Diabetes Mellitus

The Endocrinologist ◽

10.1097/ten.0b013e31815eccca ◽

2007 ◽

Vol 17 (6) ◽

pp. 306-308 ◽

Cited By ~ 2

Author(s):

Huseyin Demirci ◽

Husamettin Erdamar ◽

Ayhan Karakoc ◽

Fusun Balos Toruner ◽

Mehmet Akif Ozturk ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Hamilton rating scale for depression-24 (HAM-D24) as a novel predictor for diabetic microvascular complications in type 2 diabetes mellitus patients

Psychiatry Research ◽

10.1016/j.psychres.2017.07.050 ◽

2017 ◽

Vol 258 ◽

pp. 177-183 ◽

Cited By ~ 7

Author(s):

Shuo Pan ◽

Zhong-Wei Liu ◽

Shuang Shi ◽

Xun Ma ◽

Wen-Qian Song ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Rating Scale ◽

Diabetic Microvascular Complications ◽

Hamilton Rating Scale

Association of 2184AG Polymorphism in the RAGE Gene with Diabetic Nephropathy in Chinese Patients with Type 2 Diabetes

Journal of Diabetes Research ◽

10.1155/2015/310237 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Wei Cai ◽

Jian Li ◽

Ji-Xiong Xu ◽

Ying Liu ◽

Wei Zhang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Chinese Patients ◽

Chinese Han ◽

Genotype Frequencies ◽

Objective. The interaction between advanced glycation end products and their cellular receptor (RAGE) has an important role in the pathogenesis of diabetic microvascular complications. The aim of this study was to investigate the relationship between the 2184A/G polymorphism in the RAGE gene and diabetic nephropathy in Chinese Han patients with type 2 diabetes mellitus. Methods. A total of 868 patients with type 2 diabetes mellitus (486 without and 382 with diabetic nephropathy) were enrolled in this study. The genotype and allele frequencies of the 2184A/G polymorphism were detected using the polymerase chain reaction-restriction fragment-length polymorphism method. Results. The G allele and AG + GG genotype frequencies in patients with diabetic nephropathy were significantly lower than those in patients without diabetic nephropathy (P=0.001 and P=0.005, resp.). After adjustments for possible confounders, multivariate logistic regression analyses showed that the 2184A/G polymorphism was independently associated with diabetic nephropathy (OR = 0.46, 95% CI: 0.22–0.92, P=0.028). Conclusions. Our study indicated that the 2184A/G polymorphism in the RAGE gene was significantly associated with diabetic nephropathy in Chinese Han patients with type 2 diabetes.

Association between pancreatic steatosis and diabetic microvascular complications in type 2 diabetes mellitus

10.26226/morressier.59d51848d462b80296ca2f43 ◽

2017 ◽

Author(s):

Kwon Hyuk-Sang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetic Microvascular Complications ◽

Pancreatic Steatosis

Matrix metalloproteinase-9 gene polymorphism (-1562 C/T) and its correlation with diabetic nephropathy

The Egyptian Journal of Internal Medicine ◽

10.1186/s43162-021-00035-2 ◽

2021 ◽

Vol 33 (1) ◽

Author(s):

Kholoud Shalaby ◽

Rania Bahriz ◽

Nancy Mahsoub ◽

Mohammed M. El-Arman ◽

Ghada El-Said

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Gene Polymorphism ◽

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 9 ◽

Metalloproteinase 9

Abstract Background Matrix metalloproteinase 9 (MMP-9) is an important inflammatory marker in diabetic nephropathy. Many studies assessed the association between MMP-9 gene polymorphism and different microvascular complications of type 2 diabetes mellitus, though the results were inconclusive and need further exploration. Our study aimed to assess the association between MMP-9 -1562C/T gene polymorphism and diabetic nephropathy in patients with type 2 diabetes mellitus. Results Taking CC genotype of rs3918242 (MMP-9-1562C/T SNP) as the reference genotype and C as the reference allele, TT genotype, T allele showed significantly lower frequency in diabetic nephropathy group than without nephropathy (2.9% versus 20%, 20% versus 35.7% respectively), with the possible significant protective effect against diabetic nephropathy development (OR = 0.269, 0.450 respectively); it was considered as an independent predictor for diabetic nephropathy occurrence. Conclusions This study suggested that T allele of MMP-9 -1562C/T single nucleotide polymorphism had a protective role against diabetic nephropathy development and also had a role for early prediction of patients susceptible to this complication, so it helps in prevention and management of those patients.

The Association of Transcription Factor 7 like 2 Gene Polymorphism with Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus

Current Diabetes Reviews ◽

10.2174/1573399815666190709182713 ◽

2020 ◽

Vol 16 (4) ◽

pp. 370-375 ◽

Cited By ~ 1

Author(s):

Marianne Fathy Morgan ◽

Randa Fayez Salam ◽

Normeen Hany Rady ◽

Alshaimaa Rezk L.R. Alnaggar ◽

Soha Hamed Ammar ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Gene Polymorphism ◽

Allele Frequency ◽

Tcf7l2 Gene ◽

Significant Difference ◽

Independent Association

Background: The exact relationship between the different TCF7L2 gene polymorphisms and the development of diabetic nephropathy (DN) remains unclear. Objective: To investigate the association of TCF7L2 rs12255372 (G/T) gene polymorphism and diabetic nephropathy (DN) in patients with type 2 diabetes (T2D). Methods: 100 patients with T2D (50 patients without DN and 50 patients with DN) and 50 age and sex-matched healthy controls (HC) were enrolled in the study. Genotyping for the rs12255372 (G>T) polymorphism in the TCF7L2 gene was performed by real-time PCR. Results: The rs12255372 polymorphism showed a statistically significant difference between HC and patients with and without DN in both the genotype and allele frequency. However, the rs12255372 polymorphism genotype or allele frequency was not statistically different between patients with DN and those patients without DN. The G allele was found to be higher in patients and the T allele was higher in HC suggesting that the G allele was the risk allele for developing T2D &DN and that the T allele was protective. Conclusion: rs12255372 TCF7L2 gene polymorphism was strongly associated with type 2 diabetes mellitus and DN. The association between rs12255372 polymorphism and DN was a mere reflection of a complicated diabetes mellitus rather than a direct independent association.

Frequency of Depression in Patients with Type 2 Diabetes Mellitus and its Relationship with Glycemic Control and Diabetic Microvascular Complications

Cureus ◽

10.7759/cureus.5145 ◽

2019 ◽

Author(s):

Sabira Sharif ◽

Muhammad T Raza ◽

Samsam Mushtaq ◽

Bahjat Afreen ◽

Bushra Azam Hashmi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Glycemic Control ◽

BEHAVIORAL AND GENETICALLY DETERMINED DIFFERENCES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY RETINOPATHY WITH DIFFERENT PPARG-DEPENDENT PHENOTYPE

Medical Science of Ukraine (MSU) ◽

10.32345/2664-4738.3-4.2019.06 ◽

2019 ◽

Vol 15 (3-4) ◽

pp. 39-47

Author(s):

L.V. Natrus ◽

S.A. Rykov ◽

M.Y. Bykhovets

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Gene Polymorphism ◽

Gas Liquid Chromatography ◽

Ophthalmological Examination ◽

Wild Genotype ◽

Genetically Determined

Relevance. The problem of treatment and prevention of microvascular complications against the background of hyperglycemia is much broader than adherence to an appropriate diet. It is necessary to take into account both the behavioral characteristics of a person and the genetically determined mechanisms of metabolic regulation. Objective to study the behavioral and genetically determined differences in patients with type 2 diabetes mellitus complicated by retinopathy with different PPARG-dependent phenotype. Materials and methods. The study included 101 patients with type 2 diabetes mellitus (T2DM), who, according to the results of an ophthalmological examination, revealed various stages of diabetic retinopathy (DR) according to the ETDRS scale. The control group (CG) included 40 people without diabetes, comparable to patients by gender, age, and body mass index. Gene polymorphism was determined using real-time PCR on an automatic amplifier Gene Amp® PCR System 7500, the fatty acid spectrum (FA) was determined using gas-liquid chromatography, and behavioral and nutritional habits were analyze according to the results of a questionnaire. Results. In patients with type 2 diabetes, the most effective way to correct hyperglycemia at all stages of development of complications was the use of insulin in tablet forms. Carriers of the PPARG gene polymorphism had greater stability in achieving the target blood glucose level. The carriers of the wild genotype Pro12Pro did not differ from the CG in the rationality of nutrition and lifestyle. Carriers of the 12Ala allele were characterized by a neglect of food recommendations at the beginning of the disease, but with the progression of the degree of microvascular complications, the awareness of the need for proper nutrition doubled (P <0.05). Their lifestyle was initially less rational than that of carriers of the wild genotype Pro12Pro, but the course of T2DM and the development of complications in the form of DR by 2–3 times (P <0.05) reduced the desire for a healthy lifestyle.

The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus

Bioscience Reports ◽

10.1042/bsr20201105 ◽

2020 ◽

Vol 40 (10) ◽

Author(s):

Jieyuan Cui ◽

Xiaolin Zhang ◽

Cheng Guo ◽

Lin Zhang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Subgroup Analysis ◽

Genetic Model ◽

Meta Analysis ◽

Foot Disease ◽

Abstract Objectives: To evaluate the effects of the single-nucleotide polymorphism (SNP) rs1800795 in interieukin-6 (IL-6) gene on diabetic microvascular complications of Type 2 diabetes mellitus (T2DM), using statistical meta-analysis. Methods: Literature pertaining to the relationship between the SNP rs1800795 and microvascular complications of T2DM including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and foot disease was retrieved from PubMed, Web of Science Knowledge and SinoMed databases. Original information was analyzed using Stata 12.0, including meta-analysis statistics, test for heterogeneity, evaluation of publication bias and sensitivity. Subgroup analysis was conducted to assess the effect of specific factors on the corresponding results. Results: In total, 14 eligible articles were obtained. The SNP rs1800795 in IL-6 gene is not correlated with risk of microvascular complications in T2DM. Among the original literature, a genetic model (OR = 1.071, 95% CI: 0.681–1.685, P=0.767), an allelic genetic model (OR = 1.010, 95% CI: 0.959–1.063, P=0.703), a heterozygote genetic model (OR = 1.107, 95% CI: 0.916–1.339, P=0.292), a dominant genetic model (OR = 1.108, 95% CI: 0.885–1.387, P=0.372), and a recessive genetic model (OR = 0.978, 95% CI: 0.646–1.478, P=0.917) were included respectively. In the subgroup analysis by types of diabetic microvascular complications, we found no correlation between the SNP rs1000795 polymorphism and complications of T2DM in either the homozygote genetic model or the allelic genetic model (P<0.05). Conclusion: Our results demonstrate that rs1800795 polymorphism in IL-6 gene is not correlated with the susceptibility of microvascular complications of T2DM.