Phenylalanine-coupled solid lipid nanoparticles for brain tumor targeting

2013 ◽  
Vol 15 (11) ◽  
Author(s):  
Parul Kharya ◽  
Ashish Jain ◽  
Arvind Gulbake ◽  
Satish Shilpi ◽  
Ankit Jain ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Solid Lipid Nanoparticles ◽  
Tumor Targeting ◽  
Lipid Nanoparticles ◽  
Solid Lipid

RGD-decorated solid lipid nanoparticles enhance tumor targeting, penetration and anticancer effect of asiatic acid

Nanomedicine ◽  
2020 ◽  
Vol 15 (16) ◽  
pp. 1567-1583 ◽  
Author(s):  
Tanem Garanti ◽  
Mohamed A Alhnan ◽  
Ka-Wai Wan
Keyword(s):  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Tumor Targeting ◽  
Anticancer Agent ◽  
Specific Treatment ◽  
Lipid Nanoparticles ◽  
Asiatic Acid ◽  
Anticancer Effect ◽  
Solid Lipid ◽  
Selective Targeting

Aim: Asiatic acid (AA) is a promising anticancer agent, however, its delivery to glioblastoma is a major challenge. This work investigates the beneficial therapeutic efficacy of RGD-conjugated solid lipid nanoparticles (RGD-SLNs) for the selective targeting of AA to gliblastoma. Materials & methods: AA-containing RGD-SLNs were prepared using two different PEG-linker size. Targetability and efficacy were tested using monolayer cells and spheroid tumor models. Results: RGD-SLNs significantly improved cytotoxicity of AA against U87-MG monolayer cells and enhanced cellular uptake compared with non-RGD-containing SLNs. In spheroid models, AA-containing RGD-SLNs showed superior control in tumor growth, improved cytotoxicity and enhanced spheroid penetration when compared with AA alone or non-RGD-containing SLNs. Conclusion: This study illustrates the potential of AA-loaded RGD-SLNs as efficacious target-specific treatment for glioblastoma.

Formulation and evaluation of rutin-loaded solid lipid nanoparticles for the treatment of brain tumor

2020 ◽  
Author(s):  
Sureshbabu Ram Kumar Pandian ◽  
Parasuraman Pavadai ◽  
Sivakumar Vellaisamy ◽  
Vigneshwaran Ravishankar ◽  
Ponnusamy Palanisamy ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite
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