Improved tumor targeting and antitumor activity of camptothecin loaded solid lipid nanoparticles by preinjection of blank solid lipid nanoparticles

2016 ◽  
Vol 80 ◽  
pp. 162-172 ◽  
Author(s):  
Dong-Jin Jang ◽  
Cheol Moon ◽  
Euichaul Oh
Keyword(s):  
Antitumor Activity ◽  
Solid Lipid Nanoparticles ◽  
Tumor Targeting ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Emodin loaded solid lipid nanoparticles: Preparation, characterization and antitumor activity studies

2012 ◽  
Vol 430 (1-2) ◽  
pp. 238-246 ◽  
Author(s):  
Shengpeng Wang ◽  
Tongkai Chen ◽  
Ruie Chen ◽  
Yangyang Hu ◽  
Meiwan Chen ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Antitumor activity and pharmacokinetics of podophyllotoxin incorporated into solid lipid nanoparticles

2009 ◽  
Vol 52 (8) ◽  
pp. 1253-1257 ◽  
Author(s):  
Meng Xue ◽  
RongRong Zhu ◽  
LiLi Qin ◽  
FaJie Li ◽  
ZhiXue Liu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Coating Solid Lipid Nanoparticles with Hyaluronic Acid Enhances Antitumor Activity against Melanoma Stem-like Cells

Theranostics ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 755-771 ◽  
Author(s):  
Hongxin Shen ◽  
Sanjun Shi ◽  
Zhirong Zhang ◽  
Tao Gong ◽  
Xun Sun
Keyword(s):  
Hyaluronic Acid ◽  
Antitumor Activity ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Phenylalanine-coupled solid lipid nanoparticles for brain tumor targeting

2013 ◽  
Vol 15 (11) ◽  
Author(s):  
Parul Kharya ◽  
Ashish Jain ◽  
Arvind Gulbake ◽  
Satish Shilpi ◽  
Ankit Jain ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Solid Lipid Nanoparticles ◽  
Tumor Targeting ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Evaluation of Antitumor Activity and Development of Solid Lipid Nanoparticles of Metronidazole Analogue

2013 ◽  
Vol 9 (11) ◽  
pp. 1939-1944 ◽  
Author(s):  
Eduardo Burgarelli Lages ◽  
Maria Betânia de Freitas ◽  
Isadora Marques Brum Gonçalves ◽  
Ricardo José Alves ◽  
Cristina Duarte Vianna-Soares ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles

2013 ◽  
Vol 48 (1-2) ◽  
pp. 282-290 ◽  
Author(s):  
Samuel Vidal Mussi ◽  
Renata Carvalho Silva ◽  
Mônica Cristina de Oliveira ◽  
Carolina Madeira Lucci ◽  
Ricardo Bentes de Azevedo ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
New Approach ◽  
Solid Lipid

scholarly journals Oridonin Loaded Solid Lipid Nanoparticles Enhanced Antitumor Activity in MCF-7 Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Lu Wang ◽  
Shengpeng Wang ◽  
Ruie Chen ◽  
Yanping Wang ◽  
Hui Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Solid Lipid Nanoparticles ◽  
Human Cancer ◽  
Lipid Nanoparticles ◽  
Inhibition Of Proliferation ◽  
Solid Lipid ◽  
Cycle Arrest ◽  
Mcf 7

Oridonin (ORI), a famous diterpenoid from Chinese herbal medicine, has drawn rising attention for its remarkable apoptosis and autophagy-inducing activity in human cancer therapy, while clinical application of ORI is limited by its strong hydrophobicity and rapid plasma clearance. The purpose of this study was to evaluate whether the antitumor activity of ORI could be enhanced by loading into solid lipid nanoparticles (SLNs). ORI-loaded SLNs were prepared by hot high pressure homogenization with narrow size distribution and good entrapment efficacy. MTT assay indicated that ORI-loaded SLNs enhanced the inhibition of proliferation against several human cancer cell lines including breast cancer MCF-7 cells, hepatocellular carcinoma HepG 2 cells, and lung carcinoma A549 cells compared with free ORI, while no significant enhancement of toxicity to human mammary epithelial MCF-10A cells was shown. Meanwhile, flow cytometric analysis demonstrated that ORI-SLNs induced more significant cell cycle arrest at S and decreased cell cycle arrest at G1/G0 phase in MCF-7 cells than bulk ORI solution. Hoechst 33342 staining and Annexin V/PI assay indicated that apoptotic rates of cells treated with ORI-loaded SLNs were higher compared with free ORI. In summary, our data indicated that SLNs may be a potential carrier for enhancing the antitumor effect of hydrophobic drug ORI.

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