Electroacupuncture and Curcumin Promote Oxidative Balance and Motor Function Recovery in Rats Following Traumatic Spinal Cord Injury

2019 ◽  
Vol 44 (2) ◽  
pp. 498-506 ◽  
Author(s):  
Belen G. Alvarado-Sanchez ◽  
Hermelinda Salgado-Ceballos ◽  
Sergio Torres-Castillo ◽  
Juan Rodriguez-Silverio ◽  
Monica E. Lopez-Hernandez ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Function ◽  
Traumatic Spinal Cord Injury ◽  
Oxidative Balance ◽  
Function Recovery ◽  
Cord Injury

scholarly journals Negative Impact of Sigma-1 Receptor Agonist Treatment on Tissue Integrity and Motor Function Following Spinal Cord Injury

2021 ◽  
Vol 12 ◽  
Author(s):  
Alise Lattard ◽  
Gaëtan Poulen ◽  
Sylvain Bartolami ◽  
Yannick N. Gerber ◽  
Florence E. Perrin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Function ◽  
Negative Impact ◽  
Receptor Activation ◽  
Traumatic Spinal Cord Injury ◽  
Sigma 1 Receptor ◽  
Function Recovery ◽  
Cord Injury ◽  
Sigma 1

In traumatic spinal cord injury, the initial trauma is followed by a cascade of impairments, including excitotoxicity and calcium overload, which ultimately induces secondary damages. The sigma-1 receptor is widely expressed in the central nervous system and is acknowledged to play a key role in calcium homeostasis. Treatments with agonists of the sigma-1 receptor induce beneficial effects in several animal models of neurological diseases. In traumatic injury the use of an antagonist of the sigma-1 receptor reversed several symptoms of central neuropathic pain. Here, we investigated whether sigma-1 receptor activation with PRE-084 is beneficial or detrimental following SCI in mice. First, we report that PRE-084 treatment after injury does not improve motor function recovery. Second, using ex vivo diffusion weighted magnetic resonance imaging completed by histological analysis, we highlight that σ1R agonist treatment after SCI does not limit lesion size. Finally, PRE-084 treatment following SCI decreases NeuN expression and increases astrocytic reactivity. Our findings suggest that activation of sigma-1 receptor after traumatic spinal cord injury is detrimental on tissue preservation and motor function recovery in mice.

scholarly journals A Fully Integrated Wireless SoC for Motor Function Recovery After Spinal Cord Injury

2017 ◽  
Vol 11 (3) ◽  
pp. 497-509 ◽  
Author(s):  
Yi-Kai Lo ◽  
Yen-Cheng Kuan ◽  
Stanislav Culaclii ◽  
Brian Kim ◽  
Po-Min Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Function ◽  
Fully Integrated ◽  
Function Recovery ◽  
Cord Injury
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