scholarly journals Interspecies Pharmacokinetic Modeling of Subcutaneous Absorption of Rituximab in Mice and Rats

2014 ◽  
Vol 31 (12) ◽  
pp. 3265-3273 ◽  
Author(s):  
Leonid Kagan ◽  
Jie Zhao ◽  
Donald E. Mager
Keyword(s):  
Pharmacokinetic Modeling ◽  
Subcutaneous Absorption

Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges

2019 ◽  
Vol 24 (43) ◽  
pp. 5175-5180 ◽  
Author(s):  
Jatinder Kaur Mukker ◽  
Ravi Shankar Prasad Singh
Keyword(s):  
Drug Delivery ◽  
Modeling And Simulation ◽  
Small Molecules ◽  
Pharmacokinetic Modeling ◽  
Simulation Techniques ◽  
Modeling Techniques

The properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and simulation techniques have great potential to be used in nanoformulation development; however, their use in optimization of nanoformulation is very limited. This review highlights the differences in absorption, distribution, metabolism and excretion (ADME) characteristics of nanoparticles, use of modeling and simulation techniques in nanoformulation development and challenges in the implementation of modeling techniques.

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