Influence of water-soluble derivatives of [60]fullerene on catalytic activity of monoaminе oxidase B and their membranotropic properties

Novel complexes of cobalt(II) with sulfonated derivatives of phthalocyanines are synthesized. The influence of the sulfonated group's number in peripheral substituent on solubility of macrocycle and ability to form ordered structures in solution is showed. Transition from H-aggregates to monomeric phthalocyanine structures and sandwich-type dimers was found during formation of metallophthalocyanine complexes with 1,4-diazabicyclo[2.2.2]octane. The catalytic activity of metallophthalocyanines was studied on the model of Merox process.

Download Full-text

Membranotropic properties of the water soluble amino acid and peptide derivatives of fullerene C60

FEBS Letters ◽

10.1016/0014-5793(96)00537-6 ◽

1996 ◽

Vol 389 (2) ◽

pp. 111-114 ◽

Cited By ~ 61

Author(s):

Raisa A. Kotelnikova ◽

Alexander I. Kotelnikov ◽

Guennady N. Bogdanov ◽

Valentina S. Romanova ◽

Elena F. Kuleshova ◽

...

Keyword(s):

Amino Acid ◽

Fullerene C60 ◽

Water Soluble ◽

Peptide Derivatives ◽

Derivatives Of ◽

Membranotropic Properties

Download Full-text

Potential anticonvulsants: Substituted N-benzylidene derivatives of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19831173 ◽

1983 ◽

Vol 48 (4) ◽

pp. 1173-1186 ◽

Cited By ~ 2

Author(s):

Václav Bártl ◽

Jiří Holubek ◽

Emil Svátek ◽

Marie Bartošová ◽

Miroslav Protiva

Keyword(s):

Acute Toxicity ◽

Water Soluble ◽

Hypotensive Activity ◽

Anticonvulsant Effect ◽

Maximal Electroshock ◽

Soluble Salts ◽

Sleeping Time ◽

Central Depression ◽

Derivatives Of ◽

Electroshock Seizures

Reactions of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins XIVa-XIVd with benzaldehyde, 3,4-dimethoxybenzaldehyde, 4-dimethylaminobenzaldehyde, salicylaldehyde, 3-ethoxy-4-hydroxybenzaldehyde, 2-(2-dimethylaminoethoxy)benzaldehyde, 3-(2-dimethylaminoethoxy)benzaldehyde and 3-ethoxy-4-(2-dimethylaminoethoxy)benzaldehyde afforded a series of 19 hydrazones IIIa-Xc. Some of them showed the expected anticonvulsant effect but only towards pentetrazole; antagonism of maximal electroshock seizures was not observed. In general, the products have a character of tranquillizers: in higher does they produce central depression, potentiate the thiopental sleeping time, have hypothermic action; in single cases antiamphetamine, antireserpine, antihistamine and cataleptic effects were observed. The water-soluble salts of the basic hydrazones VIIIa, VIIIc, IXc and Xc, administered parenterally, showed a rather high acute toxicity and revealed also adrenolytic and hypotensive activity.

Download Full-text

Antioxidant Network Based on Sulfonated Polyhydroxyalkanoate and Tannic Acid Derivative

Bioengineering ◽

10.3390/bioengineering8010009 ◽

2021 ◽

Vol 8 (1) ◽

pp. 9

Author(s):

Laura Brelle ◽

Estelle Renard ◽

Valerie Langlois

Keyword(s):

Gallic Acid ◽

Tannic Acid ◽

Water Soluble ◽

Gel Formation ◽

Ene Reaction ◽

Inorganic Cations ◽

Medium Chain Length ◽

Physically Crosslinked ◽

The Stability ◽

Derivatives Of

A novel generation of gels based on medium chain length poly(3-hydroxyalkanoate)s, mcl-PHAs, were developed by using ionic interactions. First, water soluble mcl-PHAs containing sulfonate groups were obtained by thiol-ene reaction in the presence of sodium-3-mercapto-1-ethanesulfonate. Anionic PHAs were physically crosslinked by divalent inorganic cations Ca2+, Ba2+, Mg2+ or by ammonium derivatives of gallic acid GA-N(CH3)3+ or tannic acid TA-N(CH3)3+. The ammonium derivatives were designed through the chemical modification of gallic acid GA or tannic acid TA with glycidyl trimethyl ammonium chloride (GTMA). The results clearly demonstrated that the formation of the networks depends on the nature of the cations. A low viscoelastic network having an elastic around 40 Pa is formed in the presence of Ca2+. Although the gel formation is not possible in the presence of GA-N(CH3)3+, the mechanical properties increased in the presence of TA-N(CH3)3+ with an elastic modulus G’ around 4200 Pa. The PHOSO3−/TA-N(CH3)3+ gels having antioxidant activity, due to the presence of tannic acid, remained stable for at least 5 months. Thus, the stability of these novel networks based on PHA encourage their use in the development of active biomaterials.

Download Full-text

1,3-dipolar cycloaddition in the synthesis of glycoconjugates of natural chlorins and bacteriochlorins

Journal of Porphyrins and Phthalocyanines ◽

10.1142/s1088424609000425 ◽

2009 ◽

Vol 13 (03) ◽

pp. 336-345 ◽

Cited By ~ 16

Author(s):

Mikhail A. Grin ◽

Ivan S. Lonin ◽

Anna A. Lakhina ◽

Elena S. Ol'shanskaya ◽

Alexey I. Makarov ◽

...

Keyword(s):

Triple Bond ◽

Tautomeric Form ◽

Click Reaction ◽

Copper Cation ◽

Water Soluble ◽

Dipolar Cycloaddition ◽

Nmr Studies ◽

Metal Free ◽

Cu Complex ◽

Derivatives Of

Glucose-, galactose- and lactose-containing photosensitizers based on derivatives of chlorophyll a and bacteriochlorophyll a were synthesized with the use of [3+2] cycloaddition between sugar azides and triple bond derivatives of chlorins and bacteriochlorins. Unlike bacteriochlorin cycloimide, chlorin was detected to form a Cu -complex during the click reaction. An approach to the synthesis of metal-free glycosylated chlorins was developed with the use of "protection" by Zn 2+ cation and subsequent demetalation. It is based on the action of alkynyl chlorin e6 derivative Zn -complex, which is resistant to the substitution by copper cation. Bacteriochlorin p cycloimide conjugate with per-acetylated β-D-lactose was obtained and shown to become water-soluble after unblocking of the lactose hydroxy functions. NMR studies allowed for the elucidation of structure, tautomeric form and conformation of the obtained compounds.

Download Full-text