Kinetic regularities of NO donation by binuclear dinitrosyl iron complexes with thiolate ligands based on thiophenol derivatives in the presence of red blood cells

2020 ◽  
Vol 69 (10) ◽  
pp. 1987-1993
Author(s):  
N. I. Neshev ◽  
E. M. Sokolova ◽  
G. I. Kozub ◽  
T. A. Kondrat’eva ◽  
N. A. Sanina
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Thiolate Ligands ◽  
Dinitrosyl Iron

Synthesis and structure of new dinitrosyl iron complexes with bridging thiolate ligands [Fe2(μ-SR)2(NO)4]

2015 ◽  
Vol 64 (11) ◽  
pp. 2663-2666 ◽  
Author(s):  
P. B. Davidovich ◽  
V. V. Gurzhiy ◽  
A. V. Garabadzhiu ◽  
A. N. Belyaev
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Thiolate Ligands ◽  
Dinitrosyl Iron

scholarly journals Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Konstantin B. Shumaev ◽  
Irina V. Gorudko ◽  
Olga V. Kosmachevskaya ◽  
Daria V. Grigorieva ◽  
Оleg M. Panasenko ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Biological Activities ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Free Radical Scavengers ◽  
Thiolate Ligands ◽  
Dinitrosyl Iron ◽  
Regulatory Properties ◽  
Kinetics Of

Hypochlorous acid (HOCl), one of the major precursors of free radicals in body cells and tissues, is endowed with strong prooxidant activity. In living systems, dinitrosyl iron complexes (DNIC) with glutathione ligands play the role of nitric oxide donors and possess a broad range of biological activities. At micromolar concentrations, DNIC effectively inhibit HOCl-induced lysis of red blood cells (RBCs) and manifest an ability to scavenge alkoxyl and alkylperoxyl radicals generated in the reaction of HOCl withtert-butyl hydroperoxide. DNIC proved to be more effective cytoprotective agents and organic free radical scavengers in comparison with reduced glutathione (GSH). At the same time, the kinetics of HOCl-induced oxidation of glutathione ligands in DNIC is slower than in the case of GSH. HOCl-induced oxidative conversions of thiolate ligands cause modification of DNIC, which manifests itself in inclusion of other ligands. It is suggested that the strong inhibiting effect of DNIC with glutathione on HOCl-induced lysis of RBCs is determined by their antioxidant and regulatory properties.

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes of Human Fibroblasts

2018 ◽  
Vol 483 (4) ◽  
pp. 452-456
Author(s):  
A. Gizatullin ◽  
◽  
N. Akent'eva ◽  
N. Sanina ◽  
N. Shmatko ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Metabolic Processes ◽  
No Donors ◽  
Dinitrosyl Iron

The Influence of the Nature of the Ligand on the Antitumor Activity and Cytotoxic Effect of Binuclear Dinitrosyl Iron Complexes

BIOPHYSICS ◽  
2020 ◽  
Vol 65 (5) ◽  
pp. 863-868
Author(s):  
A. F. Vanin ◽  
L. A. Ostrovskaya ◽  
D. B. Korman ◽  
E. I. Nekrasova ◽  
O. O. Riabaya ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cytotoxic Effect ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Re-examination of the formation of dinitrosyl–iron complexes during reaction of S-nitrosothiols with Fe(II)

2001 ◽  
Vol 318 (1-2) ◽  
pp. 1-7 ◽  
Author(s):  
Simona Costanzo ◽  
Stephane Ménage ◽  
Roberto Purrello ◽  
Raffaele P Bonomo* ◽  
Marc Fontecave*
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron
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