Dinitrosyl Iron Complexes (DNICs) [L2Fe(NO)2]-(L = Thiolate):  Interconversion among {Fe(NO)2}9DNICs, {Fe(NO)2}10DNICs, and [2Fe-2S] Clusters, and the Critical Role of the Thiolate Ligands in Regulating NO Release of DNICs

2005 ◽  
Vol 44 (16) ◽  
pp. 5872-5881 ◽  
Author(s):  
Fu-Te Tsai ◽  
Show-Jen Chiou ◽  
Ming-Che Tsai ◽  
Ming-Li Tsai ◽  
Hsiao-Wen Huang ◽  
...  
Keyword(s):  
Critical Role ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Thiolate Ligands ◽  
No Release ◽  
Dinitrosyl Iron

scholarly journals Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Konstantin B. Shumaev ◽  
Irina V. Gorudko ◽  
Olga V. Kosmachevskaya ◽  
Daria V. Grigorieva ◽  
Оleg M. Panasenko ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Biological Activities ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Free Radical Scavengers ◽  
Thiolate Ligands ◽  
Dinitrosyl Iron ◽  
Regulatory Properties ◽  
Kinetics Of

Hypochlorous acid (HOCl), one of the major precursors of free radicals in body cells and tissues, is endowed with strong prooxidant activity. In living systems, dinitrosyl iron complexes (DNIC) with glutathione ligands play the role of nitric oxide donors and possess a broad range of biological activities. At micromolar concentrations, DNIC effectively inhibit HOCl-induced lysis of red blood cells (RBCs) and manifest an ability to scavenge alkoxyl and alkylperoxyl radicals generated in the reaction of HOCl withtert-butyl hydroperoxide. DNIC proved to be more effective cytoprotective agents and organic free radical scavengers in comparison with reduced glutathione (GSH). At the same time, the kinetics of HOCl-induced oxidation of glutathione ligands in DNIC is slower than in the case of GSH. HOCl-induced oxidative conversions of thiolate ligands cause modification of DNIC, which manifests itself in inclusion of other ligands. It is suggested that the strong inhibiting effect of DNIC with glutathione on HOCl-induced lysis of RBCs is determined by their antioxidant and regulatory properties.

Crucial role of lysosomal iron in the formation of dinitrosyl iron complexes in vivo

2006 ◽  
Vol 12 (3) ◽  
pp. 345-352 ◽  
Author(s):  
Hanna Lewandowska ◽  
Sylwia Męczyńska ◽  
Barbara Sochanowicz ◽  
Jarosław Sadło ◽  
Marcin Kruszewski
Keyword(s):  
Crucial Role ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Phosphine-ligated dinitrosyl iron complexes for redox-controlled NO release

2016 ◽  
Vol 45 (25) ◽  
pp. 10271-10279 ◽  
Author(s):  
F. Wittkamp ◽  
C. Nagel ◽  
P. Lauterjung ◽  
B. Mallick ◽  
U. Schatzschneider ◽  
...  
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
No Release ◽  
Dinitrosyl Iron

Synthesis and structure of new dinitrosyl iron complexes with bridging thiolate ligands [Fe2(μ-SR)2(NO)4]

2015 ◽  
Vol 64 (11) ◽  
pp. 2663-2666 ◽  
Author(s):  
P. B. Davidovich ◽  
V. V. Gurzhiy ◽  
A. V. Garabadzhiu ◽  
A. N. Belyaev
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Thiolate Ligands ◽  
Dinitrosyl Iron

Coordination-triggered NO release from a dinitrosyl iron complex leads to anti-inflammatory activity

2014 ◽  
Vol 5 (6) ◽  
pp. 2374-2378 ◽  
Author(s):  
Kelsey M. Skodje ◽  
Min-Young Kwon ◽  
Su Wol Chung ◽  
Eunsuk Kim
Keyword(s):  
Coordination Chemistry ◽  
Iron Complexes ◽  
Iron Complex ◽  
Dinitrosyl Iron Complexes ◽  
Inflammatory Activity ◽  
Dinitrosyl Iron Complex ◽  
No Release ◽  
Dinitrosyl Iron ◽  
Anti Inflammatory

The appropriate control of redox and coordination chemistry of dinitrosyl iron complexes enables them to become anti-inflammatory agents.

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