Global coagulation assays in hypercoagulable states

2022 ◽  
Author(s):  
Hui Yin Lim ◽  
Geoffrey Donnan ◽  
Harshal Nandurkar ◽  
Prahlad Ho
Keyword(s):  
Coagulation Assays

scholarly journals Fibrin Clot Formation and Lysis in Plasma

2020 ◽  
Vol 3 (4) ◽  
pp. 67
Author(s):  
Julie Brogaard Larsen ◽  
Anne-Mette Hvas
Keyword(s):  
Fibrinolytic Activity ◽  
Research Laboratory ◽  
Ex Vivo ◽  
Fibrin Clot ◽  
Clot Formation ◽  
Coagulation Assays ◽  
Fibrin Formation ◽  
Over Time ◽  
Routine Coagulation

Disturbance in the balance between fibrin formation and fibrinolysis can lead to either bleeding or thrombosis; however, our current routine coagulation assays are not sensitive to altered fibrinolysis. The clot formation and lysis assay is a dynamic plasma-based analysis that assesses the patient’s capacity for fibrin formation and fibrinolysis by adding an activator of coagulation as well as fibrinolysis to plasma and measuring ex vivo fibrin clot formation and breakdown over time. This assay provides detailed information on the fibrinolytic activity but is currently used for research only, as the assay is prone to inter-laboratory variation and as it demands experienced laboratory technicians as well as specialized personnel to validate and interpret the results. Here, we describe a protocol for the clot formation and lysis assay used at our research laboratory.

Screening Coagulation Assays, Factor XIII and D-dimer

2021 ◽  
pp. 11-23
Author(s):  
Dorothy M. Adcock ◽  
Brian F. Poirier
Keyword(s):  
Factor Xiii ◽  
Coagulation Assays ◽  
D Dimer

scholarly journals Global coagulation assays in patients with diabetes mellitus

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Hui Yin Lim ◽  
Brandon Lui ◽  
Mark Tacey ◽  
Anna Kwok ◽  
Suresh Varadarajan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coagulation Assays ◽  
Patients With Diabetes

Screening Coagulation Assays, Factor XIII and D-Dimer

2016 ◽  
pp. 3-16
Author(s):  
Dorothy M. Adcock ◽  
Brian F. Poirier
Keyword(s):  
Factor Xiii ◽  
Coagulation Assays ◽  
D Dimer

scholarly journals Global coagulation assays in hemophilia A: A comparison to conventional assays

2019 ◽  
Vol 4 (2) ◽  
pp. 298-308 ◽  
Author(s):  
Saman Aghighi ◽  
Anne Riddell ◽  
Christine A. Lee ◽  
Simon A. Brown ◽  
Edward Tuddenham ◽  
...  
Keyword(s):  
Hemophilia A ◽  
Coagulation Assays

scholarly journals Laboratory testing in hemophilia: Impact of factor and non‐factor replacement therapy on coagulation assays

2020 ◽  
Vol 18 (6) ◽  
pp. 1242-1255 ◽  
Author(s):  
Flora Peyvandi ◽  
Gili Kenet ◽  
Isabell Pekrul ◽  
Rajiv K. Pruthi ◽  
Peter Ramge ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Laboratory Testing ◽  
Coagulation Assays

Overview and Practical Application of Coagulation Assays in Managing Anticoagulation with Direct Oral Anticoagulants (DOACs)

2020 ◽  
Vol 6 (5) ◽  
pp. 241-259
Author(s):  
Jessica Rimsans ◽  
Jonathan Douxfils ◽  
Maureen A Smythe ◽  
Robert C Gosselin
Keyword(s):  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Practical Application ◽  
Coagulation Assays
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