Analytische und technische Evaluation gereinigter, wiederverwertbarer Küvetten am AMAX 400. Analytical and Technical Evaluation of Washed and Recycled Cuvettes for Determination of Routine Coagulation Assays on an AMAX 400

Disturbance in the balance between fibrin formation and fibrinolysis can lead to either bleeding or thrombosis; however, our current routine coagulation assays are not sensitive to altered fibrinolysis. The clot formation and lysis assay is a dynamic plasma-based analysis that assesses the patient’s capacity for fibrin formation and fibrinolysis by adding an activator of coagulation as well as fibrinolysis to plasma and measuring ex vivo fibrin clot formation and breakdown over time. This assay provides detailed information on the fibrinolytic activity but is currently used for research only, as the assay is prone to inter-laboratory variation and as it demands experienced laboratory technicians as well as specialized personnel to validate and interpret the results. Here, we describe a protocol for the clot formation and lysis assay used at our research laboratory.

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Performance and Interpretation of Routine Coagulation Assays

Laboratory Hematology Practice ◽

10.1002/9781444398595.ch32 ◽

2012 ◽

pp. 420-434

Author(s):

Kandice Kottke-Marchant

Keyword(s):

Coagulation Assays ◽

Routine Coagulation

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Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants

Journal of Thrombosis and Haemostasis ◽

10.1111/jth.12702 ◽

2014 ◽

Vol 12 (10) ◽

pp. 1636-1646 ◽

Cited By ~ 87

Author(s):

E. M. H. Schmitz ◽

K. Boonen ◽

D. J. A. van den Heuvel ◽

J. L. J. van Dongen ◽

M. W. M. Schellings ◽

...

Keyword(s):

Mass Spectrometry ◽

Therapy Monitoring ◽

Oral Anticoagulants ◽

Direct Oral Anticoagulants ◽

Ultra Performance Liquid Chromatography ◽

Tandem Mass ◽

Coagulation Assays ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Bloodhound Missile Evaluation

Journal of the Royal Aeronautical Society ◽

10.1017/s036839310007735x ◽

1962 ◽

Vol 66 (621) ◽

pp. 571-587 ◽

Cited By ~ 6

Author(s):

A. G. Biggs ◽

A. R. Cawthorne

Keyword(s):

Scientific Information ◽

Point Of View ◽

Operational Performance ◽

Critical Examination ◽

List Type ◽

Complete Evaluation ◽

Training Requirements ◽

Detail Design ◽

Technical Evaluation

The main objectives of Missile Evaluation Trials are a complete evaluation of the operational performance of the missile tested, a comprehensive assessment of the practical implications of regular operation of the weapon system from the user's point of view, and the feedback of scientific information to assist in future designs. This means that the trials must be planned to provide data on the following aspects: —(a) Scientific evaluation, i.e. determination of performance in the various conditions which will arise in operational use.(b) Technical evaluation, i.e. assessment of the detail design, workmanship, engineering and reliability and its influence on operational performance.(c) User evaluation, i.e. a practical critical examination of (and evolution of) handling and servicing procedures, personnel training requirements, installation requirements, logistics, and the numerous organisational steps necessary for the introduction of a new weapon into service.

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Preanalytical Variables in Coagulation Testing: Setting the Stage for Accurate Results

Seminars in Thrombosis and Hemostasis ◽

10.1055/s-0039-1692700 ◽

2019 ◽

Vol 45 (05) ◽

pp. 433-448 ◽

Cited By ~ 6

Author(s):

Robert C. Gosselin ◽

Richard A. Marlar

Keyword(s):

Laboratory Practice ◽

Coagulation Assays ◽

Practice Recommendations ◽

Specimen Collection ◽

Coagulation Testing ◽

Specimen Processing ◽

Processing And Storage ◽

And Storage ◽

Routine Coagulation

AbstractMany preanalytical variables may affect the results of routine coagulation assays. While advances in laboratory instrumentation have partially addressed the laboratory's ability to recognize some of these variables, there remains an increased reliance on laboratory personnel to recognize the three potential areas where coagulation testing preanalytical issues may arise: (1) specimen collection (including patient selection), (2) specimen transportation and stability, and (3) specimen processing and storage. The purpose of this article is to identify the preanalytical variables associated with coagulation-related testing and provide laboratory practice recommendations in an effort to improve the quality of coagulation testing and accuracy of result reporting.

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