Characterizing the metabolic actions of natural stresses in the California red abalone, Haliotis rufescens using 1H NMR metabolomics

Metabolomics ◽  
2005 ◽  
Vol 1 (2) ◽  
pp. 199-209 ◽  
Author(s):  
E. S. Rosenblum ◽  
M. R. Viant ◽  
B. M. Braid ◽  
J. D. Moore ◽  
C. S. Friedman ◽  
...  
Keyword(s):  
1H Nmr ◽  
Haliotis Rufescens ◽  
Nmr Metabolomics ◽  
Red Abalone

Hepatotoxicity or hepatoprotection of emodin? Two sides of the same coin by 1H-NMR metabolomics profiling

2021 ◽  
pp. 115734
Author(s):  
Lingyu Ruan ◽  
Lei Jiang ◽  
Wenlong Zhao ◽  
Huihui Meng ◽  
Qi Zheng ◽  
...  
Keyword(s):  
1H Nmr ◽  
Nmr Metabolomics ◽  
Two Sides

scholarly journals 1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints

2018 ◽  
Vol 17 (11) ◽  
pp. 3780-3790 ◽  
Author(s):  
James R. Anderson ◽  
Susama Chokesuwattanaskul ◽  
Marie M. Phelan ◽  
Tim J. M. Welting ◽  
Lu-Yun Lian ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
1H Nmr ◽  
Nmr Metabolomics ◽  
Synovial Joints

scholarly journals Foot injury survival in red abalone (Haliotis rufescens)

Aquaculture ◽  
2020 ◽  
Vol 529 ◽  
pp. 735734
Author(s):  
Malina M. Loeher ◽  
James D. Moore
Keyword(s):  
Haliotis Rufescens ◽  
Red Abalone ◽  
Foot Injury

scholarly journals Direct Implementation of Intestinal Permeability Test in NMR Metabolomics for Simultaneous Biomarker Discovery—A Feasibility Study in a Preterm Piglet Model

Metabolites ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 22 ◽  
Author(s):  
Masoumeh Alinaghi ◽  
Duc Ninh Nguyen ◽  
Per Torp Sangild ◽  
Hanne Christine Bertram
Keyword(s):  
Intestinal Permeability ◽  
1H Nmr ◽  
Biomarker Discovery ◽  
Urine Samples ◽  
Gastrointestinal Disorders ◽  
Urinary Recovery ◽  
Metabolomics Data ◽  
Enzymatic Assays ◽  
Nmr Metabolomics ◽  
Plasma And Urine Samples

Measurement of intestinal permeability (IP) is often used in the examination of inflammatory gastrointestinal disorders. IP can be assessed by measurement of urinary recovery of ingested non-metabolizable lactulose (L) and mannitol (M). The present study aimed to examine how measurements of IP can be integrated in a NMR-based metabolomics approach for a simultaneous quantification of L/M ratio and biomarker exploration. For this purpose, plasma and urine samples were collected from five-day-old preterm piglets (n = 20) with gastrointestinal disorders (subjected to intra-amniotic lipopolysaccharide (LPS, 1 mg/fetus)) after they had been administrated a 5% lactulose and 5% mannitol solution (15 mL/kg). The collected plasma and urine samples were analyzed by 1H NMR-based metabolomics. Urine L/M ratio measured by 1H NMR spectroscopy showed high correlation with the standard measurement of the urinary recoveries by enzymatic assays (r = 0.93, p < 0.05). Partial least squares (PLS) regressions and correlation analyses between L/M ratio and NMR metabolomics data revealed that L/M ratio was positively correlated with plasma lactate, acetate and succinate levels and negatively correlated with urinary hippuric acid and glycine. In conclusion, the present study demonstrated that NMR metabolomics enables simultaneous IP testing and discovery of biomarkers associated with an impaired intestinal permeability.

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