A single enteral feed prior to the commencement of parenteral nutrition ameliorates the incidence of steatosis in parenterally fed neonatal piglets

Metabolomics ◽  
2010 ◽  
Vol 7 (1) ◽  
pp. 118-125
Author(s):  
Matthew J. Hyde ◽  
Lynne Clarke ◽  
Julian L. Griffin ◽  
Emilio Herrera ◽  
Christopher D. Byrne ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Neonatal Piglets

Supplemental Parenteral Vitamin E Into Conventional Soybean Lipid Emulsion Does Not Prevent Parenteral Nutrition–Associated Liver Disease in Full-Term Neonatal Piglets

2015 ◽  
Vol 41 (4) ◽  
pp. 575-582 ◽  
Author(s):  
Mitsuru Muto ◽  
David Lim ◽  
Amanda Soukvilay ◽  
Catherine Field ◽  
Pamela R. Wizzard ◽  
...  
Keyword(s):  
Liver Disease ◽  
Vitamin E ◽  
Parenteral Nutrition ◽  
Lipid Emulsion ◽  
Full Term ◽  
Neonatal Piglets

Total Parenteral Nutrition Alters Molecular and Cellular Indices of Intestinal Inflammation in Neonatal Piglets

1999 ◽  
Vol 23 (6) ◽  
pp. 337-344 ◽  
Author(s):  
Deshanie Ganessunker ◽  
H. Rex Gaskins ◽  
Federico A. Zuckermann ◽  
Sharon M. Donovan
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Intestinal Inflammation ◽  
Neonatal Piglets

scholarly journals Threonine Requirement of Neonatal Piglets Receiving Total Parenteral Nutrition Is Considerably Lower than That of Piglets Receiving an Identical Diet Intragastrically

1998 ◽  
Vol 128 (10) ◽  
pp. 1752-1759 ◽  
Author(s):  
Robert F. P. Bertolo ◽  
Cathy Z. L. Chen ◽  
Garson Law ◽  
Paul B. Pencharz ◽  
Ronald O. Ball
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Neonatal Piglets

scholarly journals Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets

2020 ◽  
Vol 318 (1) ◽  
pp. G41-G52 ◽  
Author(s):  
Gregory Guthrie ◽  
Barbara Stoll ◽  
Shaji Chacko ◽  
Charlotte Lauridsen ◽  
Jogchum Plat ◽  
...  
Keyword(s):  
Liver Disease ◽  
Bile Acid ◽  
Vitamin E ◽  
Parenteral Nutrition ◽  
Pregnane X Receptor ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Metabolism ◽  
Neonatal Piglets ◽  
Hyocholic Acid

Infants receiving long-term parenteral nutrition (PN) develop PN-associated liver disease (PNALD). We previously (Ng K et al. JPEN J Parenter Enteral Nutr 40: 656–671, 2016. doi: 10.1177/0148607114567900 .) showed that PN containing soy-based lipid supplemented with vitamin E (α-tocopherol) prevents the development of PNALD. We hypothesize that this occurs via vitamin E activation of pregnane X receptor (PXR)-mediated pathways involved in bile acid metabolism. Neonatal piglets received PN for 14 days containing Intralipid (IL; soy-based lipid emulsion), IL supplemented with 12.6 mg·kg−1·day−1 vitamin E (VITE), or IL with 10 mg·kg−1·day−1 Rifadin IV (RIF), a PXR agonist. Pigs treated with IL and VITE, but not RIF, developed cholestasis and hyperbilirubinemia, markers of liver disease. The hepatic PXR target genes CYP3A29 and UGT1A6 increased during RIF treatment. RIF also modestly increased metabolism of chenodeoxycholic acid to the more hydrophilic bile acid hyocholic acid. Serum fibroblast growth factor (FGF)-19, a key regulator in suppressing hepatic bile acid synthesis, significantly increased in the RIF group. We conclude rifampicin modified markers of PNALD development by increased metabolism of bile acids and potentially suppressed bile acid synthesis. Vitamin E was ineffective at high lipid doses in preventing PNALD. NEW & NOTEWORTHY Intravenous vitamin E and rifampicin were administered to neonatal piglets receiving parenteral nutrition to determine their efficacy in reducing the progression of parenteral nutrition-associated liver disease (PNALD). Rifampicin increased serum FGF-19 concentrations and synthesis of the bile acid hyocholic acid which led to a reduction of PNALD parameters at 2 wk of administration. This result has potential clinical implications for the use of rifampicin as a safe and inexpensive treatment for short-term development of PNALD.

Lipid Emulsion Formulation of Parenteral Nutrition Affects Intestinal Microbiota and Host Responses in Neonatal Piglets

2016 ◽  
Vol 41 (8) ◽  
pp. 1301-1309 ◽  
Author(s):  
Celeste M. Lavallee ◽  
Jayden A. R. MacPherson ◽  
Mi Zhou ◽  
Yanhua Gao ◽  
Pamela R. Wizzard ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Intestinal Microbiota ◽  
Lipid Emulsion ◽  
Host Responses ◽  
Neonatal Piglets ◽  
Emulsion Formulation

The farnesoid X receptor agonist tropifexor prevents liver damage in parenteral nutrition-fed neonatal piglets

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yang Liu ◽  
Yongtao Xiao ◽  
Shanshan Chen ◽  
Xinbei Tian ◽  
Weipeng Wang ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Liver Damage ◽  
Receptor Agonist ◽  
Farnesoid X Receptor ◽  
Neonatal Piglets
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