Filtered air intervention reduces inflammation and hypothalamus–pituitary–adrenal axis activation in adult male and female rats after PM 2.5 exposure

2020 ◽  
Vol 27 (28) ◽  
pp. 35341-35348
Author(s):  
Cuiying Liu ◽  
Jian Yang ◽  
Longfei Guan ◽  
Yuequan Zhu ◽  
Xiaokun Geng
Keyword(s):  
Adult Male ◽  
Female Rats ◽  
Male And Female ◽  
Pm 2.5 ◽  
Adrenal Axis ◽  
Male And Female Rats ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Pituitary Adrenal Axis

Effects of dehydration on renal aminopeptidase activities in adult male and female rats

2002 ◽  
Vol 106 (1-3) ◽  
pp. 27-32 ◽  
Author(s):  
I. Prieto ◽  
G. Arechaga ◽  
A.B. Segarra ◽  
F. Alba ◽  
M. de Gasparo ◽  
...  
Keyword(s):  
Adult Male ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Intrasplenic Transplantation of Isolated Adult Rat Hepatocytes

2011 ◽  
Vol 40 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Meena R. Sharma ◽  
Wojciech Dworakowski ◽  
Bernard H. Shapiro
Keyword(s):  
Cytochrome P450 ◽  
Adult Male ◽  
Total Concentration ◽  
Rat Hepatocytes ◽  
Female Rats ◽  
Female Rat ◽  
Male And Female ◽  
Sexual Dimorphisms ◽  
Male And Female Rats ◽  
Male Specific

Adult male and female rat hepatocytes were individually transplanted into the spleens of adult male and female rats. The recipients were euthanized at either eight, sixteen, thirty, or forty-five weeks following transplantation, at which time hepatic and splenic levels of liver-specific rat albumin mRNA as well as sex-dependent transcript levels of CYP2C11, -2C12, -2C7, -2A1, and -3A2—which accounts for > 60% of the total concentration of hepatic constituent cytochrome P450—were determined. Whereas the pre-infused hepatocytes expressed their expected cytochrome P450 sexual dimorphisms (female-specific CYP2C12, male-specific CYP3A2, and female-predominant CYP2A1), their post-transplantational competence now reflected the sexual dimorphisms of the recipient (as observed in the host’s liver), which supports the concept that the sex-dependent growth hormone circulating profiles are the determinants regulating the expression levels of hepatic cytochrome P450. Also expressed at normal concentrations in the pre-infused hepatocytes, male-specific CYP2C11 and female-predominant CYP2C7 were inexplicably undetectable in the spleens of both recipient males and females, regardless of the sex of the donor hepatocytes, almost one year after transplantation.

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