scholarly journals Apolipoprotein E4 Suppresses Neuronal-Specific Gene Expression in Maturing Neuronal Progenitor Cells Exposed to HIV

2017 ◽  
Vol 12 (3) ◽  
pp. 462-483 ◽  
Author(s):  
Rebeca Geffin ◽  
Ricardo Martinez ◽  
Alicia de las Pozas ◽  
Biju Issac ◽  
Micheline McCarthy
Keyword(s):  
Gene Expression ◽  
Progenitor Cells ◽  
Specific Gene ◽  
Apolipoprotein E4 ◽  
Specific Gene Expression ◽  
Neuronal Progenitor Cells ◽  
Neuronal Progenitor

scholarly journals Sizn1 Is a Novel Protein That Functions as a Transcriptional Coactivator of Bone Morphogenic Protein Signaling

2007 ◽  
Vol 28 (5) ◽  
pp. 1565-1572 ◽  
Author(s):  
Ginam Cho ◽  
Youngshin Lim ◽  
Dina Zand ◽  
Jeffrey A. Golden
Keyword(s):  
Gene Expression ◽  
System Development ◽  
Nervous System Development ◽  
Bmp Signaling ◽  
Specific Gene ◽  
Protein Signaling ◽  
Transcriptional Coactivator ◽  
Specific Gene Expression ◽  
Neuronal Progenitor ◽  
Positive Modulator

ABSTRACT Bone morphogenic proteins (BMPs) play pleotrophic roles in nervous system development, and their signaling is highly regulated at virtually every step in the pathway. We have cloned a novel gene, Sizn1 (Smad-interacting zinc finger protein), which functions as a transcriptional coactivator of BMP signaling. It positively modulates BMP signaling by interacting with Smad family members and associating with CBP in the transcription complex. Sizn1 is expressed in the ventral embryonic forebrain, where, as we will show, it contributes to BMP-dependent, cholinergic-neuron-specific gene expression. These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development.

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