scholarly journals The role of MRI in cervical cancer > 2 cm (FIGO stage IB2-IIA1) conservatively treated with neoadjuvant chemotherapy followed by conization: a pilot study

2021 ◽  
Author(s):  
Luca Russo ◽  
Benedetta Gui ◽  
Maura Miccò ◽  
Camilla Panico ◽  
Rosa De Vincenzo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Pilot Study ◽  
Neoadjuvant Chemotherapy ◽  
Treatment Response ◽  
Young Women ◽  
Figo Stage ◽  
Tumor Diameter ◽  
Recist 1.1 ◽  
Fertility Sparing

Abstract Introduction MRI is very accurate in selecting young women with cervical cancer for fertility-sparing surgery (FSS), in particular radical hysterectomy (RH). In order to improve obstetrical outcomes, neoadjuvant chemotherapy (NACT) followed by cold knife conization (CKC) has been proposed as alternative technique. Objective To investigate the role of MRI in evaluation of response to treatment after neoadjuvant chemotherapy (NACT), followed by CKC, in patients with cervical cancer FIGO stage IB2-IIA1 with tumor size 2 – 4 cm, desiring to preserve their fertility. Methods 13 young women (23–36 years old) with cervical cancer stage IB2-IIA1 desiring to preserve their fertility were included. Tumor diameter at baseline and after treatment was detected on 1.5 T MRI. Treatment response was assessed according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1) and then compared to histopathology result. Results MRI correctly assessed 11 out of 13 cases, according to RECIST 1.1, compared to histopathology. Among these 7 patients with partial response (PR), 2 cases of CR, 1 SD and 1 PD with persistence or enlargement of primary tumor. Conclusion Our pilot study supports the usefulness of MRI in assessment of treatment response after NACT, followed by CKC. Trial registration number ClinicalTrials.gov: NCT02323841

scholarly journals Fertility sparing surgery following neoadjuvant chemotherapy of cervical cancer figo stage IB2 - case report

2019 ◽  
Author(s):  
Aljosa Mandic ◽  
Miona Davidovic-Grigoraki ◽  
Bojana Gutic ◽  
Natasa Prvulovic Bunovic ◽  
Nenad Solajic ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Case Report ◽  
Neoadjuvant Chemotherapy ◽  
Figo Stage ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Neoadjuvant chemotherapy and vaginal radical trachelectomy for fertility-sparing treatment in women affected by cervical cancer (FIGO stage IB–IIA1)

2011 ◽  
Vol 122 (3) ◽  
pp. 484-490 ◽  
Author(s):  
Pierangelo Marchiole ◽  
Jean-Dominique Tigaud ◽  
Sergio Costantini ◽  
Serafina Mammoliti ◽  
Annie Buenerd ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Figo Stage ◽  
Radical Trachelectomy ◽  
Stage Ib ◽  
Fertility Sparing

The Role of Neoadjuvant Chemotherapy and Surgery in Cervical Cancer

2010 ◽  
Vol 20 (Suppl 2) ◽  
pp. S42-S46 ◽  
Author(s):  
Helena Robova ◽  
Michael Halaska ◽  
Marek Pluta ◽  
Petr Skapa ◽  
Pavel Strnad ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Radical Hysterectomy ◽  
Locally Advanced ◽  
Nerve Sparing ◽  
High Dose ◽  
Cancer Management ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

The role of neoadjuvant chemotherapy (NAC) in "bulky" and locally advanced cervical cancer has been of interest for the last 25 years, and in many countries, NAC has become the standard of care. In the present paper, we review our 10 years' experience with high-dose-density NAC in cervical cancer management in 141 women (CervNAC I protocol). High-dose-density neoadjuvant chemotherapy and radical surgery has resulted in high clinical response rates and seems to be feasible in the management of stage IB bulky cervical cancer. Neoadjuvant chemotherapy reduces tumor volume and positivity of lymph nodes and thus minimizes the need for postoperative radiotherapy or chemoradiotherapy. Tumor size reduction and node negativity allows less radical surgical procedures such as modified radical hysterectomy or nerve-sparing radical hysterectomy. Early and especially late toxicity of our high-dose density chemotherapy is acceptable. Neoadjuvant chemotherapy followed by surgery represents a valid alternative to primary chemoradiotherapy in young and sexually active patients. Five-year survival in patients who underwent surgery in our study was 80.6%.Currently, 3 papers with 3 approaches have been published on NAC before fertility-sparing surgery. One of the limitations of fertility-preserving surgery is deep stromal invasion and tumors larger than 2 cm. The idea underlying NAC is to reduce the size of the cervical tumor to preserve fertility. In the present paper, we also review our experience with high-dose-density NAC in fertility-sparing surgery in 15 women (LAP3-NAC protocol).

Fertility Preservation in Young Women With Cervical Cancer: An Oncologic Dilemma or a New Conception of Fertility Sparing Surgery?

2013 ◽  
Vol 31 (3) ◽  
pp. 189-189 ◽  
Author(s):  
Salvatore Gizzo ◽  
Emanuele Ancona ◽  
Tito Silvio Patrelli ◽  
Carlo Saccardi ◽  
Omar Anis ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Fertility Preservation ◽  
Young Women ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Effects of Neoadjuvant Chemotherapy Plus Radical Surgery as Front Line Treatment Strategy in Patients Affected by FIGO Stage III Cervical Cancer

2016 ◽  
Vol 23 (S5) ◽  
pp. 841-849 ◽  
Author(s):  
Violante Di Donato ◽  
Michele Carlo Schiavi ◽  
Ilary Ruscito ◽  
Virginia Sibilla Visentin ◽  
Innocenza Palaia ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Treatment Strategy ◽  
Radical Surgery ◽  
Figo Stage ◽  
Stage Iii ◽  
Line Treatment ◽  
Front Line

scholarly journals Surgical and pathologic outcomes of fertility-sparing radical abdominal trachelectomy for FIGO stage IB1 cervical cancer

2008 ◽  
Vol 111 (2) ◽  
pp. 261-264 ◽  
Author(s):  
Nadeem R. Abu-Rustum ◽  
Nikki Neubauer ◽  
Yukio Sonoda ◽  
Kay J. Park ◽  
Mary Gemignani ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Figo Stage ◽  
Fertility Sparing

Early-Stage Cervical Cancer

2021 ◽  
pp. 139-157
Author(s):  
Maria Luisa Fais ◽  
Giorgio Candotti ◽  
Giulia Carboni ◽  
Speranza Luisa Anedda ◽  
Valerio Mais ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Early Stage ◽  
Reproductive Potential ◽  
Conservative Surgery ◽  
High Resource ◽  
Incidence And Mortality ◽  
Fertility Sparing ◽  
Early Stage Cervical Cancer ◽  
Lymph Node Assessment

Recent advances in screening and early diagnosis have decreased cervical cancer incidence and mortality rate in high-resource settings. The postponement of childbearing and the young age of women at diagnosis produced new challenges in the management of this disease. In recent years, attention has been directed to assessing more conservative procedures that can reduce treatment-related morbidity, without compromising oncologic safety and reproductive potential. Fertility sparing surgery (FSS) procedures, including cervical conization, simple or radical trachelectomy with pelvic nodes dissection or sentinel lymph node assessment, and neoadjuvant chemotherapy followed by conization, have shown encouraging results. In this chapter, the authors discuss the role of conservative surgery in the management of early-stage cervical cancer focusing on obstetrical and oncological outcomes.

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