The Prognosis Value of Lymphatic Vessel Invasion in pN0 Gastric Cancer Patients with Insufficient Examined Lymph Nodes

Mdthod :110 gastric cancer patients were selected from Feb 2004 to Jan 2006, who had complete pathological data and were underwent radical resection. All patients were diagnosed by endoscopy, preoperative histologic diagnosis and exclusion from distant metastasis, using D1 or D2 lymph node dissection, postoperative pathology confirmed stump negative. Univariate analysis was applied on the pathologic information and multivariate analysis was applied based on the univariate analysis. Result :(1)Univariate analysis showed that tumor diameter、histology、vascular invasion、lymphatic vessel invasion and neural invasion were correlated with T/N classification.Multivariate analysis showed that vascular invasion and lymphatic vessel invasion were correlated with T classification and lymphatic vessel invasion was associated with N classification. (2) For T and N stages, lymphatic vessel invasion was strongly related factor. Conclusion: For T and N stages,, lymphatic vessel invasion was strongly relevant factor. For patients with confirmed lymphatic vessel invasion, postoperative adjuvant radiotherapy is suggested.

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Recurrence in node-negative advanced gastric cancer with novel clinical and pathologic findings

10.21203/rs.3.rs-38675/v1 ◽

2020 ◽

Author(s):

Shangqi Chen ◽

Can Hu ◽

Zhiyuan Xu ◽

Jianfa Yu ◽

Xiaofeng Wang ◽

...

Keyword(s):

Gastric Cancer ◽

Advanced Gastric Cancer ◽

Cancer Patients ◽

Tumor Invasion ◽

Lymphatic Vessel ◽

Lymphatic Vessel Invasion ◽

Histological Grading ◽

Node Negative ◽

Vessel Invasion ◽

Gastric Cancer Patients

Abstract Background Node-negative gastric cancer patients carry a better prognosis than node-positive. However, a subset of these patients eventually died due to the high recurrence rate of recurrence. This study investigated the clinic-pathologic factors for recurrent patterns and prognosis. Methods The detailed medical records of 947 gastric cancer patients who underwent gastrectomy from the prospectively collected database of the Gastrointestinal Surgery Department of the First Affiliated Hospital of Zhejiang Chinese Medical University From January 2012 to December 2014 were analyzed retrospectively. Results Tumor size, tumor invasion, histological grading were the predictive factors for locoregional recurrence. Tumor invasion, histological grading, Lauren type and lymphatic vessel invasion resulted significantly in predicting peritoneal recurrence. Two parameters, tumor invasion and lymphatic vessel invasion, were significantly associated with hematogenous spread. The combinatorial biomarker of positive for both Ki67 and P53 was significantly associated with recurrence-free survival (RFS) (P = 0.037). Histological grading (P = 0.020), tumor invasion (P = 0.007) and lymphatic vessel invasion (P = 0.012) were independent factors related to overall survival (OS) in node-negative advanced gastric cancer patients. Conclusion The reported clinicopathologic factors for different recurrence patterns and the prognostic factors of RFS and OS should be considered to guide clinicians choose appropriate postoperative treatment strategy and construct individual follow-up schedule to improve prognosis of node-negative gastric cancer.

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