Relation of Blood Arsenic Concentration with Effect and Safety of Arsenic-Containing Qinghuang Powder (青黄散) in Patients with Myelodysplastic Syndrome

Objective. To establish the clinical safe and effective methods of arsenic-containing compound-Qinghuang Powder (compound-QHP) in the treatment of myelodysplastic syndrome (MDS). Methods. 200 patients with MDS were treated with compound-QHP (daily dose of 0.1 g realgar). The blood arsenic concentrations (BACs) were detected by atomic fluorescence spectrophotometry (HF-AFS). After treatment for 1 month, the patients were randomly divided into group A and group B when the BACs were less than 20 μg/L. Daily dose of realgar was maintained in group A and it was increased to that when the BACs were more than 20 μg/L in group B. The BAC and clinical efficacy and safety in two groups were compared at the end of the treatment with compound-QHP. Results. The average BAC of group B was significantly higher than that of group A (P<0.01). The rates of hematology improvement and reduced transfusion were significantly higher in group B than in group A (P<0.05). The HGB, ANC, and PLT significantly increased in group B after treatment (P>0.05). Conclusions. Monitoring the BAC and adjusting the daily dose of realgar to increase the effective BAC and then improving efficacy without increasing the clinical toxicity are the clinical safe and effective methods in the treatment of MDS.

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Morphometric Analysis of the Hepatocytes from Fish Exposed to Arsenic

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100091391 ◽

1976 ◽

Vol 34 ◽

pp. 282-283

Author(s):

Elsie M. B. Sorensen

Keyword(s):

Morphometric Analysis ◽

Arsenic Concentration ◽

Ultrastructural Changes ◽

Sodium Arsenate ◽

Lepomis Cyanellus ◽

Mammalian Counterpart ◽

Intracellular Changes ◽

Green Sunfish ◽

Organic Pesticides

The detoxification capacity of the liver is well documented for a variety of substances including ethanol, organic pesticides, drugs, and metals. The piscean liver, although less enzymatically active than the mammalian counterpart (1), contains endoplasmic reticulum with an impressive repertoire of oxidizing, reducing, and conjugating abilities (2). Histopathologic changes are kncwn to occur in fish hepatocytes following in vivo exposure to arsenic (3); however, ultrastructural changes have not been reported. This study involved the morphometric analysis of intracellular changes in fish parynchymal hepatocytes and correlation with arsenic concentration in the liver.Green sunfish (Lepomis cyanellus, R.) were exposed to 0, 30, or 60 ppm arsenic (as sodium arsenate) at 20°C for 1, 2, or 3 week intervals before removal of livers for quantification of the arsenic burden (using neutron activation analysis) and morphometric analysis of ultrastructural alterations. Livers were cut into 1 mm cubes for fixation, dehydration, and embedding.

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Study of dislocation loops in Arsenic-Rich as-grown GaAs

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100126548 ◽

1987 ◽

Vol 45 ◽

pp. 350-351

Author(s):

Byung-Teak Lee

Keyword(s):

Point Defects ◽

Electronic Devices ◽

Arsenic Concentration ◽

Stoichiometric Compound ◽

Dislocation Loops ◽

Gaas Crystal ◽

Ion Milling ◽

Transmission Electron ◽

Arsenic Source ◽

High Arsenic

Grown-in dislocations in GaAs have been a major obstacle in utilizing this material for the potential electronic devices. Although it has been proposed in many reports that supersaturation of point defects can generate dislocation loops in growing crystals and can be a main formation mechanism of grown-in dislocations, there are very few reports on either the observation or the structural analysis of the stoichiometry-generated loops. In this work, dislocation loops in an arsenic-rich GaAs crystal have been studied by transmission electron microscopy.The single crystal with high arsenic concentration was grown using the Horizontal Bridgman method. The arsenic source temperature during the crystal growth was about 630°C whereas 617±1°C is normally believed to be optimum one to grow a stoichiometric compound. Samples with various orientations were prepared either by chemical thinning or ion milling and examined in both a JEOL JEM 200CX and a Siemens Elmiskop 102.

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