Intrinsic connectivity identifies the sensory-motor network as a main cross-network between remitted late-life depression- and amnestic mild cognitive impairment-targeted networks

2019 ◽  
Vol 14 (4) ◽  
pp. 1130-1142 ◽  
Author(s):  
Jiu Chen ◽  
Hao Shu ◽  
Zan Wang ◽  
Yafeng Zhan ◽  
Duan Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Late Life ◽  
Amnestic Mild Cognitive Impairment ◽  
Late Life Depression ◽  
Motor Network ◽  
Intrinsic Connectivity ◽  
Sensory Motor

Late-Life Depression versus Amnestic Mild Cognitive Impairment: Alzheimer’s Disease Incidence in 4 Years of Follow-Up

2018 ◽  
Vol 46 (3-4) ◽  
pp. 140-153 ◽  
Author(s):  
Michele Lauriola ◽  
Antonio Mangiacotti ◽  
Grazia D’Onofrio ◽  
Leandro Cascavilla ◽  
Francesco Paris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Medical Condition ◽  
Disease Incidence ◽  
Late Life ◽  
Amnestic Mild Cognitive Impairment ◽  
Late Life Depression

Background/Aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer’s disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. Results: The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type. Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.

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