Patterns of hippocampal atrophy differ among Alzheimer's disease, amnestic mild cognitive impairment, and late-life depression

Background/Aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer’s disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. Results: The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type. Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.

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3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease

Brain ◽

10.1093/brain/awl274 ◽

2006 ◽

Vol 129 (11) ◽

pp. 2867-2873 ◽

Cited By ~ 159

Author(s):

L. G. Apostolova ◽

I. D. Dinov ◽

R. A. Dutton ◽

K. M. Hayashi ◽

A. W. Toga ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Amnestic Mild Cognitive Impairment ◽

Hippocampal Atrophy

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Association between motor task acquisition and hippocampal atrophy across cognitively unimpaired, amnestic Mild Cognitive Impairment, and Alzheimer's disease individuals

10.1101/2021.05.31.21258061 ◽

2021 ◽

Author(s):

Sydney Y Schaefer ◽

Michael Malek-Ahmadi ◽

Andrew Hooyman ◽

Jace B. King ◽

Kevin Duff

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Sex Education ◽

Low Cost ◽

Motor Task ◽

Amnestic Mild Cognitive Impairment ◽

Hippocampal Atrophy ◽

Task Acquisition

Hippocampal atrophy is a widely used biomarker for Alzheimer's disease (AD), but the cost, time, and contraindications associated with magnetic resonance imaging (MRI) limit its use. Recent work has shown that a low-cost upper extremity motor task has potential in identifying AD risk. Fifty-four older adults (15 cognitively unimpaired, 24 amnestic Mild Cognitive Impairment, and 15 AD) completed six motor task trials and a structural MRI. Motor task acquisition significantly predicted bilateral hippocampal volume, controlling for age, sex, education, and memory. Thus, this motor task may be an affordable, non-invasive screen for AD risk and progression.

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Association Between Motor Task Performance and Hippocampal Atrophy Across Cognitively Unimpaired, Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease Individuals

Journal of Alzheimer s Disease ◽

10.3233/jad-210665 ◽

2021 ◽

pp. 1-7

Author(s):

Sydney Y. Schaefer ◽

Michael Malek-Ahmadi ◽

Andrew Hooyman ◽

Jace B. King ◽

Kevin Duff

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Task Performance ◽

Sex Education ◽

Low Cost ◽

Motor Task ◽

Amnestic Mild Cognitive Impairment ◽

Hippocampal Atrophy

Hippocampal atrophy is a widely used biomarker for Alzheimer’s disease (AD), but the cost, time, and contraindications associated with magnetic resonance imaging (MRI) limit its use. Recent work has shown that a low-cost upper extremity motor task has potential in identifying AD risk. Fifty-four older adults (15 cognitively unimpaired, 24 amnestic mild cognitive impairment, and 15 AD) completed six motor task trials and a structural MRI. Several measures of motor task performance significantly predicted bilateral hippocampal volume, controlling for age, sex, education, and memory. Thus, this motor task may be an affordable, non-invasive screen for AD risk and progression.

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Altered Volume and Structural Connectivity of the Hippocampus in Alzheimer’s Disease and Amnestic Mild Cognitive Impairment

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.705030 ◽

2021 ◽

Vol 13 ◽

Author(s):

Feng Feng ◽

Weijie Huang ◽

Qingqing Meng ◽

Weijun Hao ◽

Hongxiang Yao ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Diffusion Tensor ◽

Structural Connectivity ◽

Hippocampal Volume ◽

Brain Regions ◽

Amnestic Mild Cognitive Impairment ◽

Hippocampal Atrophy

Background: Hippocampal atrophy is a characteristic of Alzheimer’s disease (AD). However, alterations in structural connectivity (number of connecting fibers) between the hippocampus and whole brain regions due to hippocampal atrophy remain largely unknown in AD and its prodromal stage, amnestic mild cognitive impairment (aMCI).Methods: We collected high-resolution structural MRI (sMRI) and diffusion tensor imaging (DTI) data from 36 AD patients, 30 aMCI patients, and 41 normal control (NC) subjects. First, the volume and structural connectivity of the bilateral hippocampi were compared among the three groups. Second, correlations between volume and structural connectivity in the ipsilateral hippocampus were further analyzed. Finally, classification ability by hippocampal volume, its structural connectivity, and their combination were evaluated.Results: Although the volume and structural connectivity of the bilateral hippocampi were decreased in patients with AD and aMCI, only hippocampal volume correlated with neuropsychological test scores. However, positive correlations between hippocampal volume and ipsilateral structural connectivity were displayed in patients with AD and aMCI. Furthermore, classification accuracy (ACC) was higher in AD vs. aMCI and aMCI vs. NC by the combination of hippocampal volume and structural connectivity than by a single parameter. The highest values of the area under the receiver operating characteristic (ROC) curve (AUC) in every two groups were all obtained by combining hippocampal volume and structural connectivity.Conclusions: Our results showed that the combination of hippocampal volume and structural connectivity (number of connecting fibers) is a new perspective for the discrimination of AD and aMCI.

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