Safety and efficacy of synchronous robotic surgery for colorectal cancer with liver metastases

2018 ◽  
Vol 12 (4) ◽  
pp. 603-606 ◽  
Author(s):  
Rozana H. Dwyer ◽  
Matthew J. Scheidt ◽  
J. Stephen Marshall ◽  
Steven S. Tsoraides
Keyword(s):  
Colorectal Cancer ◽  
Robotic Surgery ◽  
Liver Metastases ◽  
Safety And Efficacy

Robotic procedure versus open surgery for simultaneous resection of colorectal cancer with liver metastases: Short-term outcomes of a randomized controlled study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 3575-3575
Author(s):  
Jianmin Xu ◽  
Ye Wei ◽  
Qinghai Ye ◽  
Xiaoying Wang ◽  
Wenju Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Robotic Surgery ◽  
Sexual Function ◽  
Liver Metastases ◽  
Open Surgery ◽  
Robotic Arm ◽  
Robot Assisted ◽  
Short Term ◽  
Safety And Efficacy ◽  
Robotic Procedure

3575 Background: The simultaneous resecting both colorectal cancer and liver metastases is a safety and efficacy surgical procedure for treating colorectal cancer patients with liver metastases (CRCLM).The safety and efficacy of robot-assisted simultaneous resection of CRCLM is unclear. Furthermore, what kind of selective CRCLM patients would obtain benefits from robotic procedure need identify. The aim of this study was designed to compare robotic procedure with open surgery, and establish robotic surgery indications to identify benefit population of CRCLM. Methods: CRCLM patients were evaluated and confirmed with surgical indication by multidisciplinary team (MDT), and randomized to two groups, robotic arm (n = 58) and open arm (n = 57). The primary endpoint is 3-year DFS, the second endpoints include short-term surgical outcomes, complications and safety. Results: A total of 115 patients were randomized between September 2013 and September 2016. Despite longer operating time, patients assigned to robot-assisted surgery had less blood loss (100ml vs. 150ml, P < 0.001), a shorter time to pass first flatus (3 d vs. 4 d, P < 0.001) and return to diet (3 d vs. 5 d, P = 0.002), shorter hospital stay with improved sexual function. Furthermore, followed benefits were observed in robotic arm versus open arm: lower serum C reactive protein (CRP) level on postoperative day 1 (POD1) (16 mg/L vs. 37 mg/L,P < 0.001), and POD3 (112 mg/L vs. 160 mg/L, P < 0.001), lower level of liver transaminase on POD5, and lower liver-related complication morbidity(10.3% vs 28.1%, p = 0.016). In addition, we identified and recommended selective CRCLM patients with the number of liver metastases < 3, maximal tumor size < 5cm, tumor not located in segment I to accept robotic procedure. Conclusions: We identified and recommended selective CRCLM patients to accept robotic surgery for treating liver metastases. Robotic surgery result in similar safety as open procedure, with shorter recovery time, decreased morbidity, and improved sexual function. Clinical trial information: NCT02642978.

scholarly journals Updates of colorectal cancer liver metastases therapy: review on DEBIRI

2020 ◽  
Vol 7 (1) ◽  
pp. HEP16 ◽  
Author(s):  
Giammaria Fiorentini ◽  
Donatella Sarti ◽  
Roberto Nani ◽  
Camillo Aliberti ◽  
Caterina Fiorentini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Systemic Chemotherapy ◽  
Tumor Response ◽  
Public Health Issue ◽  
Advanced Stage ◽  
Stage At Diagnosis ◽  
Colorectal Cancer Liver Metastases ◽  
Safety And Efficacy ◽  
Metastatic Sites

Colorectal cancer is a worldwide public health issue, presenting an advanced stage at diagnosis in more than 20% of patients. Liver metastases are the most common metastatic sites and are not indicated for resection in 80% of cases. Unresectable colorectal cancer liver metastases that are refractory to systemic chemotherapy may benefit from transarterial chembolization with irinotecan-loaded beads (DEBIRI). Several studies show the safety and efficacy of DEBIRI for the treatment of colorectal cancer liver metastases. The development of transarterial chembolization and the introduction of new embolics have contributed to better outcomes of DEBIRI. This article reviews the current literature on DEBIRI reporting its use, efficacy in terms of tumor response and survival and side effects.

scholarly journals Updated survival outcomes and analysis of long-term survivors from the MORE study on safety and efficacy of radioembolization in patients with unresectable colorectal cancer liver metastases

2017 ◽  
Vol 8 (4) ◽  
pp. 614-624 ◽  
Author(s):  
Andrew Kennedy ◽  
Michael Cohn ◽  
Douglas M. Coldwell ◽  
Alain Drooz ◽  
Eduardo Ehrenwald ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Survival Outcomes ◽  
Colorectal Cancer Liver Metastases ◽  
Safety And Efficacy ◽  
Long Term Survivors

Evaluation of the safety and efficacy of simultaneous resection of primary colorectal cancer and synchronous colorectal liver metastases

Surgery ◽  
2014 ◽  
Vol 155 (3) ◽  
pp. 478-485 ◽  
Author(s):  
Ryuji Yoshioka ◽  
Kiyoshi Hasegawa ◽  
Yoshihiro Mise ◽  
Masaru Oba ◽  
Taku Aoki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Primary Colorectal Cancer ◽  
Safety And Efficacy ◽  
Simultaneous Resection ◽  
Synchronous Colorectal Liver Metastases

A systematic review on the safety and efficacy of yttrium-90 radioembolization for unresectable, chemorefractory colorectal cancer liver metastases

2013 ◽  
Vol 140 (4) ◽  
pp. 537-547 ◽  
Author(s):  
Akshat Saxena ◽  
Lourens Bester ◽  
Leonard Shan ◽  
Marlon Perera ◽  
Peter Gibbs ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Safety And Efficacy ◽  
Yttrium 90

scholarly journals Feasibility, safety and efficacy of two-stage hepatectomy for bilobar liver metastases of colorectal cancer: a LiverMetSurvey analysis

HPB ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. 396-405 ◽  
Author(s):  
Jean Marc Regimbeau ◽  
Cyril Cosse ◽  
Gernot Kaiser ◽  
Catherine Hubert ◽  
Christophe Laurent ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Two Stage ◽  
Safety And Efficacy
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