Robotic procedure versus open surgery for simultaneous resection of colorectal cancer with liver metastases: Short-term outcomes of a randomized controlled study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 3575-3575
Author(s):  
Jianmin Xu ◽  
Ye Wei ◽  
Qinghai Ye ◽  
Xiaoying Wang ◽  
Wenju Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Robotic Surgery ◽  
Sexual Function ◽  
Liver Metastases ◽  
Open Surgery ◽  
Robotic Arm ◽  
Robot Assisted ◽  
Short Term ◽  
Safety And Efficacy ◽  
Robotic Procedure

3575 Background: The simultaneous resecting both colorectal cancer and liver metastases is a safety and efficacy surgical procedure for treating colorectal cancer patients with liver metastases (CRCLM).The safety and efficacy of robot-assisted simultaneous resection of CRCLM is unclear. Furthermore, what kind of selective CRCLM patients would obtain benefits from robotic procedure need identify. The aim of this study was designed to compare robotic procedure with open surgery, and establish robotic surgery indications to identify benefit population of CRCLM. Methods: CRCLM patients were evaluated and confirmed with surgical indication by multidisciplinary team (MDT), and randomized to two groups, robotic arm (n = 58) and open arm (n = 57). The primary endpoint is 3-year DFS, the second endpoints include short-term surgical outcomes, complications and safety. Results: A total of 115 patients were randomized between September 2013 and September 2016. Despite longer operating time, patients assigned to robot-assisted surgery had less blood loss (100ml vs. 150ml, P < 0.001), a shorter time to pass first flatus (3 d vs. 4 d, P < 0.001) and return to diet (3 d vs. 5 d, P = 0.002), shorter hospital stay with improved sexual function. Furthermore, followed benefits were observed in robotic arm versus open arm: lower serum C reactive protein (CRP) level on postoperative day 1 (POD1) (16 mg/L vs. 37 mg/L,P < 0.001), and POD3 (112 mg/L vs. 160 mg/L, P < 0.001), lower level of liver transaminase on POD5, and lower liver-related complication morbidity(10.3% vs 28.1%, p = 0.016). In addition, we identified and recommended selective CRCLM patients with the number of liver metastases < 3, maximal tumor size < 5cm, tumor not located in segment I to accept robotic procedure. Conclusions: We identified and recommended selective CRCLM patients to accept robotic surgery for treating liver metastases. Robotic surgery result in similar safety as open procedure, with shorter recovery time, decreased morbidity, and improved sexual function. Clinical trial information: NCT02642978.

Safety and efficacy of synchronous robotic surgery for colorectal cancer with liver metastases

2018 ◽  
Vol 12 (4) ◽  
pp. 603-606 ◽  
Author(s):  
Rozana H. Dwyer ◽  
Matthew J. Scheidt ◽  
J. Stephen Marshall ◽  
Steven S. Tsoraides
Keyword(s):  
Colorectal Cancer ◽  
Robotic Surgery ◽  
Liver Metastases ◽  
Safety And Efficacy

scholarly journals Sex, Type of Surgery, and Surgical Site Infections Are Associated with Perioperative Cortisol in Colorectal Cancer Patients

2021 ◽  
Vol 10 (4) ◽  
pp. 589
Author(s):  
Mariusz G. Fleszar ◽  
Paulina Fortuna ◽  
Marek Zawadzki ◽  
Paweł Hodurek ◽  
Iwona Bednarz-Misa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Open Surgery ◽  
Surgical Site Infections ◽  
Time Profile ◽  
C Reactive Protein ◽  
Robot Assisted ◽  
Related Factors ◽  
Reactive Protein ◽  
Baseline Cortisol ◽  
Colorectal Cancer Patients

Excessive endocrine response to trauma negatively affects patients’ well-being. Cortisol dynamics following robot-assisted colorectal surgery are unknown. We aimed at determining the impact of cancer pathology and surgery-related factors on baseline cortisol levels and analyzed its time-profile in colorectal cancer patients undergoing open or robot-assisted surgery. Cortisol levels were measured using liquid chromatography quadrupole time-of-flight mass spectrometry. Baseline cortisol was not associated with any patient- or disease-related factors. Post-surgery cortisol increased by 36% at 8 h and returned to baseline on postoperative day three. The cortisol time profile was significantly affected by surgery type, estimated blood loss, and length of surgery. Baseline-adjusted cortisol increase was greater in females at hour 8 and in both females and patients from open surgery group at hour 24. Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1β, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-α but did not correlate with changes in IL-6 or interferon (IFN)-γ at any time-point. Cortisol co-examined with C-reactive protein was predictive of surgical site infections (SSI) with high accuracy. In conclusion, patient’s sex and surgery invasiveness affect cortisol dynamics. Surgery-induced elevation can be reduced by minimally invasive robot-assisted procedures. Cortisol and C-reactive protein as SSI biomarkers might be of value in the evaluation of safety of early discharge of patients.

Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer

2009 ◽  
Vol 96 (12) ◽  
pp. 1458-1467 ◽  
Author(s):  
J. Neudecker ◽  
F. Klein ◽  
R. Bittner ◽  
T. Carus ◽  
A. Stroux ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Randomized Trial ◽  
Open Surgery ◽  
Prospective Randomized Trial ◽  
Short Term

scholarly journals Comparison of Short-Term Outcomes Between Robotic-Assisted and Laparoscopic Surgery in Colorectal Cancer

2018 ◽  
Vol 26 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Xiao-Long Zhu ◽  
Pei-Jing Yan ◽  
Liang Yao ◽  
Rong Liu ◽  
De-Wang Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Surgery ◽  
Colorectal Surgery ◽  
Hospital Stay ◽  
Bowel Function ◽  
Postoperative Recovery ◽  
Postoperative Hospital Stay ◽  
Robot Assisted ◽  
Short Term ◽  
Robotic Colorectal Surgery

Aim. The robotic technique has been established as an alternative approach to laparoscopy in colorectal surgery. The aim of this study was to compare short-term outcomes of robot-assisted and laparoscopic surgery in colorectal cancer. Methods. The cases of robot-assisted or laparoscopic colorectal resection were collected retrospectively between July 2015 and October 2017. We evaluated patient demographics, perioperative characteristics, and pathologic examination. A multivariable linear regression model was used to assess short-term outcomes between robot-assisted and laparoscopic surgery. Short-term outcomes included time to passage of flatus and postoperative hospital stay. Results. A total of 284 patients were included in the study. There were 104 patients in the robotic colorectal surgery (RCS) group and 180 in the laparoscopic colorectal surgery (LCS) group. The mean age was 60.5 ± 10.8 years, and 62.0% of the patients were male. We controlled for confounding factors, and then the multiple linear model regression indicated that the time to passage of flatus in the RCS group was 3.45 days shorter than the LCS group (coefficient = −3.45, 95% confidence interval [CI] = −5.19 to −1.71; P < .001). Additionally, the drainage of tube duration (coefficient = 0.59, 95% CI = 0.3 to 0.87; P < .001) and transfers to the intensive care unit (coefficient = 7.34, 95% CI = 3.17 to 11.5; P = .001) influenced the postoperative hospital stay. The total costs increased by 15501.48 CNY in the RCS group compared with the LCS group ( P = .008). Conclusions. The present study suggests that colorectal cancer robotic surgery was more beneficial to patients because of shorter postoperative recovery time of bowel function and shorter hospital stays.

PE07: Short-term results after robot-assisted laparoscopic radical prostatectomy compared to open surgery

2014 ◽  
Vol 13 (3) ◽  
pp. 18
Author(s):  
A. Wallerstedt ◽  
S. Tyritzis ◽  
T. Thorsteinsdottir ◽  
S. Carlsson ◽  
J. Stranne ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Open Surgery ◽  
Laparoscopic Radical Prostatectomy ◽  
Robot Assisted ◽  
Short Term

scholarly journals Laparoscopic surgery for patients with colorectal cancer produces better short‐term outcomes with similar survival outcomes in elderly patients compared to open surgery

2016 ◽  
Vol 5 (6) ◽  
pp. 1047-1054 ◽  
Author(s):  
Soo Yun Moon ◽  
Sohee Kim ◽  
Soo Young Lee ◽  
Eon Chul Han ◽  
Sung‐Bum Kang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Surgery ◽  
Elderly Patients ◽  
Open Surgery ◽  
Survival Outcomes ◽  
Short Term ◽  
Similar Survival

scholarly journals Rezum: a new transurethral water vapour therapy for benign prostatic hyperplasia

2018 ◽  
Vol 10 (11) ◽  
pp. 327-333 ◽  
Author(s):  
Jennifer Westwood ◽  
Robert Geraghty ◽  
Patrick Jones ◽  
Bhavan P. Rai ◽  
Bhaskar K. Somani
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Minimally Invasive ◽  
Sexual Function ◽  
Water Vapour ◽  
Thermal Energy ◽  
Prostatic Hyperplasia ◽  
Benign Prostatic Enlargement ◽  
Short Term ◽  
Safety And Efficacy ◽  
Prostatic Enlargement

Rezum is a minimally invasive transurethral water vapour therapy for benign prostatic enlargement which uses thermal energy for treatment. The short-term results show it to have good outcomes with a potential for outpatient-based treatment preserving sexual function. This review serves to provide an overview of the technique and evaluate its safety and efficacy.

scholarly journals Updates of colorectal cancer liver metastases therapy: review on DEBIRI

2020 ◽  
Vol 7 (1) ◽  
pp. HEP16 ◽  
Author(s):  
Giammaria Fiorentini ◽  
Donatella Sarti ◽  
Roberto Nani ◽  
Camillo Aliberti ◽  
Caterina Fiorentini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Systemic Chemotherapy ◽  
Tumor Response ◽  
Public Health Issue ◽  
Advanced Stage ◽  
Stage At Diagnosis ◽  
Colorectal Cancer Liver Metastases ◽  
Safety And Efficacy ◽  
Metastatic Sites

Colorectal cancer is a worldwide public health issue, presenting an advanced stage at diagnosis in more than 20% of patients. Liver metastases are the most common metastatic sites and are not indicated for resection in 80% of cases. Unresectable colorectal cancer liver metastases that are refractory to systemic chemotherapy may benefit from transarterial chembolization with irinotecan-loaded beads (DEBIRI). Several studies show the safety and efficacy of DEBIRI for the treatment of colorectal cancer liver metastases. The development of transarterial chembolization and the introduction of new embolics have contributed to better outcomes of DEBIRI. This article reviews the current literature on DEBIRI reporting its use, efficacy in terms of tumor response and survival and side effects.

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