Grahani Roga described in classical text books of Ayurveda represents a group of disorders of digestive system caused by impairment of Agni. Grahani is such a disorder, where in its significance is emphasized by its inclusion among Ashtamaha Gadas. The cardinal features of Grahani explained in the clasical text books of Ayurveda, have at most similarities with the clinical features of Irritable Bowel Syndrome (IBS) explained in western medicine. A total of 15 patients were selected and treated with Erandamooladi Niruha Basti and Changeryadi Ghrita Anuvasana Basti, was given in Yoga Basti pattern according to inclusive and exclusive criteria. Special case proforma was designed and parameters were assessed. It showed highly significant results in all the parameters at the level of p less than 0.01.