scholarly journals Comparative clinical study of Nagradya Churna and Bhunimbadya Churna in management of Grahani w.s.r. to Irritable bowel syndrome

2020 ◽  
Vol 5 (01) ◽  
pp. 87-97
Author(s):  
Darshana . ◽  
Amitabh Singh
Keyword(s):  
Clinical Trial ◽  
Irritable Bowel Syndrome ◽  
Small Intestine ◽  
Clinical Study ◽  
Large Intestine ◽  
Gi Tract ◽  
Highly Effective ◽  
Comparative Clinical Study ◽  
Irritable Bowel ◽  
Almost All

Grahani Dosha is vitiation of Agni i.e. functional derangement of Grahani regarding production of Pachaka Pitta (enzymes responsible for digestion) and also holding (Grahana) of Ama (food) for digestion. Grahani in Ayurveda is called as Pittadhara kala which is the seat of Agni responsible for digestion of food and situated above Nabhi. The part of small intestine and large intestine lying between Amashaya and Pakwashaya should be considered as Grahani. This part is also described as the sole site of Pitta. Various disorders of GI tract like irritable bowel syndrome (IBS) can be considered under heading of Grahani Roga. Both the formulations Nagradya Churna and Bhunimbadya churna are highly effective, promote appetite, digestion and remove Ama Dosha from the system by increasing the power of Agni. Madhu is Yogabahi and it helps to initiate the absorption through intestine properly. Total 40 patients of Grahani were registered and randomly divided into 2 groups for clinical trial of 45days. Result of the study revealed that both the formulations produced significant results in almost all cases barring a few patients who were suffering from longer period.

A comparative clinical study to evaluate the efficacy of Shuntyadi Churna and Mustakadi Churna in the management of Grahani Roga w.s.r. to Irritable Bowel Syndrome

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr.K. G. Muddapur ◽  
Dr.Uma A. Patil
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Study ◽  
Independent Effect ◽  
First Line ◽  
Comparative Clinical Study ◽  
Irritable Bowel

Grahani is the seat of Agni and it is so called because of holding up the food. The term Grahani Dosha implies the malfunctioning of Agni. Improper digestion of ingested food causes Grahani Dosha. If left untreated it finally leads to Grahani Roga. Muhurbadha and Muhurdrava Mala Pravrutti is the main Lakshana and associated with symptoms like Udarashoola, Arochaka, Sharirika Balakshaya, Asthi Parvashoola, Avipaka etc. As Agnimandya is the main cause, the first line of treatment is to correct the Dusti of Agni. Shuntyadi Churna and Mustakadi Churna have the qualities of Deepana, Pachana, Grahi, etc. and can be used in Sarvagrahani Chikitsa. This study is undertaken to clinically analyze the independent effect of Shuntyadi Churna and Mustakadi Churna in Grahani Roga. The study shows that both Shuntyadi Churna and Mustakadi Churna are effective in relieving the symptoms of Grahani Roga.

scholarly journals Efficacy of Fenoverine and Trimebutine in the Management of Irritable Bowel Syndrome: Multicenter Randomized Double-blind Non-inferiority Clinical Study

2013 ◽  
Vol 62 (5) ◽  
pp. 278 ◽  
Author(s):  
Seong Hee Kang ◽  
Yoon Tae Jeen ◽  
Ja Seol Koo ◽  
Yang Seo Koo ◽  
Kyoung Oh Kim ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Study ◽  
Double Blind ◽  
Irritable Bowel

scholarly journals Evaluation of Small Intestinal Motility in a Rat Model of Irritable Bowel Syndrome

2021 ◽  
Author(s):  
Masamichi Sato ◽  
Takahiro Kudo ◽  
Nobuyasu Arai ◽  
Reiko Kyodo ◽  
Kenji Hosoi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Small Intestine ◽  
Real Time ◽  
Rat Model ◽  
Intestinal Motility ◽  
Restraint Stress ◽  
Rat Models ◽  
Small Intestinal Motility ◽  
Small Intestinal ◽  
Irritable Bowel

Abstract Background: The correlation between small intestinal motility alteration and irritable bowel syndrome (IBS) is not well evaluated. Aims: To assess the small intestinal and colonic transits in an IBS rat model with restraint stress and determine the role of small intestinal motility in the IBS pathophysiology.Methods: Restraint stress was utilized to make adolescent IBS rat models that were evaluated for clinical symptoms, including stool frequency and diarrhea. The small intestinal motility and transit rate were also evaluated. The amounts of mRNA encoding corticotropin-releasing hormone, mast cell, and serotonin (5-Hydroxytryptamine; 5-HT) receptor 3a were quantified using real-time polymerase chain reaction (PCR); the 5-HT expression was evaluated using immunostaining.Results: Restraint stress significantly increased the number of fecal pellet outputs, stool water content, and small intestinal motility in the IBS rat models. There was no difference in real-time PCR results, but immunostaining analysis revealed that 5-HT expression in the small intestine was significantly increased in the IBS rat models.Conclusions: In the adolescent rat model of IBS with restraint stress, we observed an increase in small intestinal and colonic motility. In the small intestine, enhanced 5-HT secretion in the distal portion may be involved in increasing the small intestinal motility.

scholarly journals Randomised clinical trial: minesapride vs placebo for irritable bowel syndrome with predominant constipation

2020 ◽  
Vol 52 (3) ◽  
pp. 430-441 ◽  
Author(s):  
Tatsuto Hamatani ◽  
Shin Fukudo ◽  
Yosuke Nakada ◽  
Hiroshi Inada ◽  
Kiyoyasu Kazumori ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Irritable Bowel Syndrome ◽  
Randomised Clinical Trial ◽  
Irritable Bowel
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