Living with and beyond metastatic non-small cell lung cancer: the survivorship experience for people treated with immunotherapy or targeted therapy

2021 ◽  
Author(s):  
Julia Lai-Kwon ◽  
Sarah Heynemann ◽  
Jacinthe Flore ◽  
Haryana Dhillon ◽  
Mary Duffy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Walter Z. Wang ◽  
Konstantin Shilo ◽  
Joseph M. Amann ◽  
Alyssa Shulman ◽  
Mohammad Hojjat-Farsangi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Therapeutic Target ◽  
Small Cell ◽  
Orphan Receptor ◽  
Small Cell Lung ◽  
Sclc Patient

AbstractSmall cell lung cancer (SCLC) remains a deadly form of cancer, with a 5-year survival rate of less than 10 percent, necessitating novel therapies. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein that is emerging as a therapeutic target and is co-expressed with BCL2 in multiple tumor types due to microRNA coregulation. We hypothesize that ROR1-targeted therapy is effective in small cell lung cancer and synergizes with therapeutic BCL2 inhibition. Tissue microarrays (TMAs) and formalin-fixed paraffin-embedded (FFPE) SCLC patient samples were utilized to determine the prevalence of ROR1 and BCL2 expression in SCLC. Eight SCLC-derived cell lines were used to determine the antitumor activity of a small molecule ROR1 inhibitor (KAN0441571C) alone and in combination with the BCL2 inhibitor venetoclax. The Chou-Talalay method was utilized to determine synergy with the drug combination. ROR1 and BCL2 protein expression was identified in 93% (52/56) and 86% (48/56) of SCLC patient samples, respectively. Similarly, ROR1 and BCL2 were shown by qRT-PCR to have elevated expression in 79% (22/28) and 100% (28/28) of SCLC patient samples, respectively. KAN0441571C displayed efficacy in 8 SCLC cell lines, with an IC50 of 500 nM or less. Synergy as defined by a combination index of <1 via the Chou-Talalay method between KAN0441571C and venetoclax was demonstrated in 8 SCLC cell lines. We have shown that ROR1 inhibition is synergistic with BCL2 inhibition in SCLC models and shows promise as a novel therapeutic target in SCLC.

scholarly journals P1.26: A Case of Non Small Cell Lung Cancer EGFR Mutation EXON 18 Positive With Poor Response to Targeted Therapy

2016 ◽  
Vol 11 (10) ◽  
pp. S198
Author(s):  
Margarida Felizardo ◽  
Cláudia P. Matos ◽  
Sofia T. Furtado ◽  
José P. Coelho
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Egfr Mutation ◽  
Poor Response ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals EGFR-Targeted Therapy for Non-Small Cell Lung Cancer: Focus on EGFR Oncogenic Mutation

2013 ◽  
Vol 10 (3) ◽  
pp. 320-330 ◽  
Author(s):  
Alberto Antonicelli ◽  
Stefano Cafarotti ◽  
Alice Indini ◽  
Alessio Galli ◽  
Andrea Russo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Oncogenic Mutation

Bone Metastases and Non-Small Cell Lung Cancer: From Bisphosfonates to Targeted Therapy

2012 ◽  
Vol 19 (32) ◽  
pp. 5524-5535 ◽  
Author(s):  
A. Rossi ◽  
C. Gridelli ◽  
S. Ricciardi ◽  
F. de Marinis
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Small Cell Lung Cancer ◽  
Bone Metastases ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

Detecting resistance in EGFR-mutated non-small-cell lung cancer after clonal selection through targeted therapy

2015 ◽  
Vol 12 (2) ◽  
pp. 63-66 ◽  
Author(s):  
Justine L Kuiper ◽  
Idris Bahce ◽  
Charlotte Voorhoeve ◽  
Maqsood Yaqub ◽  
Daniëlle AM Heideman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Clonal Selection ◽  
Small Cell ◽  
Small Cell Lung ◽  
Egfr Mutated
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