Social adjustment across the lifespan in survivors of pediatric acute lymphoblastic leukemia (ALL): a systematic review

2022 ◽  
Author(s):  
Sara Cho ◽  
Courtney Tromburg ◽  
Caitlin Forbes ◽  
Andrew Tran ◽  
Elleine Allapitan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Lymphoblastic Leukemia ◽  
Social Adjustment ◽  
Lymphoblastic Leukemia ◽  
Pediatric Acute Lymphoblastic Leukemia

Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review

2014 ◽  
Vol 61 (7) ◽  
pp. 1313-1318 ◽  
Author(s):  
L.T. Warris ◽  
M.M. van den Heuvel-Eibrink ◽  
M.A.H. den Hoed ◽  
F.K. Aarsen ◽  
R. Pieters ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Lymphoblastic Leukemia ◽  
Side Effects ◽  
Lymphoblastic Leukemia ◽  
Pediatric Acute Lymphoblastic Leukemia

Non-relapse mortality in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis

2012 ◽  
Vol 53 (5) ◽  
pp. 878-885 ◽  
Author(s):  
Esther Blanco ◽  
Joseph Beyene ◽  
Anne Marie Maloney ◽  
Rowena Almeida ◽  
Marie-Chantal Ethier ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Meta Analysis ◽  
Pediatric Acute Lymphoblastic Leukemia

scholarly journals Risk factors for steroid‐induced adverse psychological reactions and sleep problems in pediatric acute lymphoblastic leukemia: A systematic review

2021 ◽  
Author(s):  
Annelienke M. van Hulst ◽  
Shosha H. M. Peersmann ◽  
Erica L. T. van den Akker ◽  
Linda J. Schoonmade ◽  
Marry M. van den Heuvel‐Eibrink ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Acute Lymphoblastic Leukemia ◽  
Sleep Problems ◽  
Lymphoblastic Leukemia ◽  
Psychological Reactions ◽  
Pediatric Acute Lymphoblastic Leukemia

scholarly journals Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shumaila Sayyab ◽  
Anders Lundmark ◽  
Malin Larsson ◽  
Markus Ringnér ◽  
Sara Nystedt ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Large Scale ◽  
Somatic Mutations ◽  
Lymphoblastic Leukemia ◽  
Clonal Evolution ◽  
Point Mutations ◽  
Driver Genes ◽  
Protein Coding ◽  
Pediatric Acute Lymphoblastic Leukemia ◽  
Evolutionary Trajectories

AbstractThe mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission from 29 Nordic patients. Somatic point mutations and large-scale structural variants were called using individually matched remission samples as controls, and allelic expression of the mutations was assessed in ALL cells using RNA-sequencing. We observed an increased burden of somatic mutations at relapse, compared to diagnosis, and at second relapse compared to first relapse. In addition to 29 known ALL driver genes, of which nine genes carried recurrent protein-coding mutations in our sample set, we identified putative non-protein coding mutations in regulatory regions of seven additional genes that have not previously been described in ALL. Cluster analysis of hundreds of somatic mutations per sample revealed three distinct evolutionary trajectories during ALL progression from diagnosis to relapse. The evolutionary trajectories provide insight into the mutational mechanisms leading relapse in ALL and could offer biomarkers for improved risk prediction in individual patients.

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