A case of benign metastasizing leiomyoma: Pathobiological behavior showing a low-grade malignant potential

2008 ◽  
Vol 5 (2) ◽  
pp. 154-156
Author(s):  
Huachuan Zheng ◽  
Tsuneyama Koichi ◽  
Takano Yasuo
Keyword(s):  
Malignant Potential ◽  
Low Grade ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Benign Metastasizing Leiomyoma of the Uterus

1999 ◽  
Vol 123 (10) ◽  
pp. 960-962 ◽  
Author(s):  
Jose M. Esteban ◽  
Warren M. Allen ◽  
Raymond H. Schaerf
Keyword(s):  
Low Grade ◽  
Benign Metastasizing Leiomyoma ◽  
Nuclear Pleomorphism ◽  
Benign Leiomyoma ◽  
Histopathologic Evaluation ◽  
Primary Neoplasm ◽  
Metastasizing Leiomyoma ◽  
Immunohistochemical Studies ◽  
Leiomyoma Of The Uterus ◽  
Rule Out

Abstract Benign uterine leiomyoma metastasizing to the lung is a recognized entity that has been reported infrequently in the medical literature. There is persisting controversy regarding the pathogenesis and biology of these lesions. We report a well-studied and well-characterized case of benign leiomyoma metastasizing to the lung. The patient was a 72-year-old woman with an enlarged uterus that contained several leiomyomas with usual histology. Areas of fibrosis, hyalinization, edema, and focal infarction together with small foci with mildly increased cellularity and minimal nuclear pleomorphism were seen. Careful and repeated mitotic counts ranged from 0 to 2 mitoses per 10 high-power fields. In summary, based on histopathologic criteria, the neoplasm was determined to be a focally cellular benign leiomyoma. Four years later, the patient underwent surgical resection of a single nodule in the lung, which had been detected on routine radiographs. Histopathologic evaluation showed a low-grade leiomyosarcoma with moderate nuclear pleomorphism, necrosis, and brisk mitotic activity. Immunohistochemical studies performed on both neoplasms showed them to be of mesenchymal derivation with smooth muscle differentiation. Both neoplasms expressed estrogen receptors with moderate to strong intensity. The patient received no further treatment and, to date, shows no evidence of recurrent disease. The diagnosis of benign metastasizing leiomyoma can only be made with certainty after careful and extensive sampling of the primary tumor to exclude small foci of sarcoma and of the pulmonary tumor to rule out a primary neoplasm. Although it is biologically peculiar, benign metastasizing leiomyoma should continue to be recognized as a distinct entity because current morphologic criteria do not allow primary myometrial tumors to be reclassified as leiomyomas of uncertain malignant potential even if they have metastasized to the lung.

Unusual CT Findings of a Benign Metastasizing Leiomyoma Presenting with Multiple Cavitary Nodules: A Case Report

2007 ◽  
Vol 57 (3) ◽  
pp. 239
Author(s):  
Ji Eun Ahn ◽  
Kyung-Hyun Do ◽  
Eun Jin Chae ◽  
Joon Beom Seo ◽  
Jin Seong Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Findings ◽  
Metastasizing Leiomyoma

scholarly journals 364 Management of benign metastasizing leiomyoma: a report of three cases

2020 ◽  
Author(s):  
K Inoue ◽  
M Yamaguchi ◽  
T Ueda ◽  
R Isono ◽  
Y Takimoto ◽  
...  
Keyword(s):  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Relationship between Immunophenotype and Clinicopathological Findings for Superficial Nonampullary Duodenal Epithelial Tumor

Digestion ◽  
2021 ◽  
pp. 1-8
Author(s):  
Shigeki Fukusada ◽  
Takaya Shimura ◽  
Hiroyasu Iwasaki ◽  
Yusuke Okuda ◽  
Takahito Katano ◽  
...  
Keyword(s):  
Malignant Potential ◽  
Low Grade ◽  
Negative Group ◽  
Epithelial Tumor ◽  
Endoscopic Findings ◽  
Intestinal Phenotype ◽  
Oral Side ◽  
Clinicopathological Findings ◽  
Gastric Phenotype ◽  
The Relationship

<b><i>Introduction:</i></b> The natural history and prognosis of superficial nonampullary duodenal epithelial tumors (SNADETs) remain uncertain. We elucidated the relationship between immunophenotype and clinicopathological features. <b><i>Materials and Methods:</i></b> A total of 98 SNADETs were divided into 3 groups according to immunohistochemical findings: gastric phenotype (G type), gastrointestinal phenotype (GI type), and intestinal phenotype (I type). Cellular dysplasia was divided into low-grade dysplasia and high-grade dysplasia/adenocarcinoma (≥HGD). White opaque substance (WOS) deposition was categorized into diffuse WOS, partial WOS, and no WOS, based on endoscopic findings. <b><i>Results:</i></b> Of the 98 SNADETs, 4 lesions (4.1%) were G type, 32 lesions (32.7%) were GI type, and 62 lesions (63.2%) were I type. All G-type SNADETs were located in the oral side of the papilla including the bulb, and the rate of bulbar lesions was significantly higher in the G type than in the GI and I types (<i>p</i> = 0.004). The most frequent type of WOS was no WOS (4/4, 100%) for G type, partial WOS (19/32, 59.4%) for GI type, and diffuse WOS (34/62, 54.8%) for I type (<i>p</i> &#x3c; 0.001), and loss of intestinal character was significantly correlated with WOS deficiency. GI/I-type SNADETs with partial or no WOS and G-type SNADETs were associated with ≥HGD. Additionally, the frequency of ≥HGD lesion was significantly higher in the CD10-negative group than in the CD10-positive group (57.1 vs. 19.8%, <i>p</i> = 0.043). <b><i>Conclusion:</i></b> Pathological intestinal character was correlated with the presence of WOS, and CD10 loss was associated with malignant potential of SNADETs.

Benign metastasizing leiomyoma

Herz ◽  
2013 ◽  
Vol 39 (7) ◽  
pp. 867-870 ◽  
Author(s):  
A. Cai ◽  
L. Li ◽  
H. Tan ◽  
Y. Mo ◽  
Y. Zhou
Keyword(s):  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma
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