Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

2015 ◽  
Vol 17 (12) ◽  
Author(s):  
Waqas T. Qureshi ◽  
Jamal S. Rana ◽  
Joseph Yeboah ◽  
Usama bin Nasir ◽  
Mouaz H. Al-Mallah
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Primary Prevention ◽  
Risk Stratification ◽  
Coronary Artery Calcium ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Artery Disease

scholarly journals Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 394 ◽  
Author(s):  
Julius Nikorowitsch ◽  
Francisco Ojeda ◽  
Karl J. Lackner ◽  
Renate B. Schnabel ◽  
Stefan Blankenberg ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiovascular Death ◽  
Adverse Outcomes ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Artery Disease

Risk stratification among patients with coronary artery disease (CAD) is of considerable interest to potentially guide secondary preventive therapies. Cardiac troponins as well as C-reactive protein (hsCRP) and natriuretic peptides have emerged as biomarkers for risk stratification. The question remains if one of these biomarkers is superior in predicting adverse outcomes. Thus, we perform a head-to-head comparison between high-sensitivity troponin I (hsTnI), hsCRP, and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with CAD. Plasma levels were measured in a cohort of 2193 patients with documented CAD. The main outcome measures were cardiovascular (CV) death and/or nonfatal myocardial infarction (MI). During a median follow-up of 3.8 years, all three biomarkers were associated with cardiovascular death and/or MI. After adjustments for conventional cardiovascular risk factors, the hazard ratio (HR) per standard deviation (SD) for the prediction of CV death and/or nonfatal MI was 1.39 [95% CI: 1.24–1.57, p < 0.001] for hsTnI, 1.41 [95% CI: 1.24–1.60, p < 0.001] for hsCRP, and 1.64 [95% CI: 1.39–1.92, p < 0.001] for NT-proBNP. However, upon further adjustments for the other two biomarkers, only NT-proBNP was still associated with the combined endpoint with an HR of 1.47 [95% CI: 1.19–1.82, p < 0.001]. Conclusively, NT-proBNP is reliably linked to CV death and MI in patients with CAD and provides incremental value beyond hsCRP and hsTnI.

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

2013 ◽  
Author(s):  
Janusz Szkodzinski ◽  
Bartosz Hudzik ◽  
Aleksander Danikiewicz ◽  
Anna Pietka-Rzycka ◽  
Andrzej Lekston ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Severity ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Disease Severity ◽  
Artery Disease ◽  
Sensitive Marker
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