Success at Last: A Molecular Factor That Informs Treatment

This study shows an efficient applicability of computational techniques to analyses of microbial depolymerisation process. Microorganisms were cultivated in a culture media in which a polymer was a sole carbon source, and weight distributions before and after cultivation were introduced into inverse analysis for a molecular factor and a time factor of a degradation rate. An inverse problem for two parameter values associated with the time factor was solved numerically. Once the molecular factor and the time factor were given, microbial depolymerization process was simulated.

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Differentiation inducing factors in Dictyostelium discoideum: A novel low molecular factor functions at an early stage(s) of differentiation

Development Growth & Differentiation ◽

10.1111/j.1440-169x.2009.01133.x ◽

2009 ◽

Vol 51 (9) ◽

pp. 743-752 ◽

Cited By ~ 5

Author(s):

Akiko A. Oohata ◽

Masashi Fukuzawa ◽

Rie Hotta ◽

Manabu Nakagawa ◽

Masatake Niwa ◽

...

Keyword(s):

Dictyostelium Discoideum ◽

Early Stage ◽

Molecular Factor ◽

Inducing Factors

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Molecular Factor Computing for Predictive Spectroscopy

Pharmaceutical Research ◽

10.1007/s11095-007-9260-1 ◽

2007 ◽

Vol 24 (8) ◽

pp. 1441-1449 ◽

Cited By ~ 4

Author(s):

Bin Dai ◽

Aaron Urbas ◽

Craig C. Douglas ◽

Robert A. Lodder

Keyword(s):

Molecular Factor

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Molecular Factor Analysis Applied To Collections of NMR Spectra

Analytical Chemistry ◽

10.1021/ac035301g ◽

2004 ◽

Vol 76 (7) ◽

pp. 1982-1990 ◽

Cited By ~ 17

Author(s):

Charles D. Eads ◽

Carrie M. Furnish ◽

Isao Noda ◽

Kenton D. Juhlin ◽

Dale A. Cooper ◽

...

Keyword(s):

Factor Analysis ◽

Nmr Spectra ◽

Molecular Factor

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Flow-Induced Crystallization in Butene-1/1,5-Hexadiene Copolymers: Mutual Effects of Molecular Factor and Flow Stimuli

Macromolecules ◽

10.1021/acs.macromol.0c01318 ◽

2020 ◽

Vol 53 (19) ◽

pp. 8476-8486

Author(s):

Long Liu ◽

Zhaozhe Chu ◽

Yilong Liao ◽

Zhe Ma ◽

Yuesheng Li

Keyword(s):

Molecular Factor ◽

Induced Crystallization ◽

Flow Induced Crystallization

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Molecular factor analysis in atom-transfer reactions

Molecular Physics ◽

10.1080/00268970500417085 ◽

2006 ◽

Vol 104 (5-7) ◽

pp. 731-743 ◽

Cited By ~ 3

Author(s):

M. Barroso ◽

J. C. Pereira ◽

A. A. C. C. Pais ◽

L. G. Arnaut ◽

S. J. Formosinho

Keyword(s):

Factor Analysis ◽

Transfer Reactions ◽

Atom Transfer ◽

Molecular Factor ◽

Atom Transfer Reactions

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Intrabronchial Application of Extracellular Histones Shows No Proinflammatory Effects in Swine in a Translational Pilot Study

10.21203/rs.3.rs-362861/v1 ◽

2021 ◽

Author(s):

Robert Ruemmler ◽

Alexander Ziebart ◽

Elisabeth Britten ◽

Moritz Gosling ◽

Rene Rissel ◽

...

Keyword(s):

Pilot Study ◽

Porcine Model ◽

Inflammatory Responses ◽

Mortality Rates ◽

Injury Model ◽

Molecular Factor ◽

Extracellular Histones ◽

Lung Injury Model ◽

In Vivo Effects

Abstract Objective: Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local and systemic histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously.Results: The targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. Additionally, intravenous histone injection had no effect. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.

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