BRCA1 – Conductor of the Breast Stem Cell Orchestra: The Role of BRCA1 in Mammary Gland Development and Identification of Cell of Origin of BRCA1 Mutant Breast Cancer

2012 ◽  
Vol 8 (3) ◽  
pp. 982-993 ◽  
Author(s):  
Niamh E. Buckley ◽  
Paul B. Mullan
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Cell Of Origin ◽  
Breast Stem Cell ◽  
Gland Development

Lifelong exposure to n-3 PUFA affects pubertal mammary gland development

2014 ◽  
Vol 39 (6) ◽  
pp. 699-706 ◽  
Author(s):  
Breanne M. Anderson ◽  
Mira B. MacLennan ◽  
Lyn M. Hillyer ◽  
David W.L. Ma
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dietary Fat ◽  
Mammary Gland Development ◽  
Morphological Development ◽  
Terminal End Buds ◽  
Gland Development

There is growing evidence that early developmental periods may importantly influence future breast cancer risk. Also, there is great interest in the role of dietary fat in breast cancer risk, but the role of dietary fat during pubertal mammary gland development remains poorly understood. This study investigated the effect of n-3 polyunsaturated fatty acids (PUFA) using complementary dietary and genetic approaches to examine the effect of lifelong exposure of n-3 PUFA or n-6 PUFA (control) on mammary gland development and fatty acid composition. n-3 PUFA from both diet and genetics were enriched in mammary glands as early as 3 weeks of age. Parameters related to mammary gland development, including number of terminal end buds (TEB), percent coverage of ductal tree, and infiltration of TEB, were influenced by n-3 PUFA at 3 and 4 weeks of age. Overall, findings suggest that n-3 PUFA incorporation into the mammary gland early in life plays a role in the morphological development of the mammary gland during puberty.

scholarly journals Role of JNK in Mammary Gland Development and Breast Cancer

2011 ◽  
Vol 72 (2) ◽  
pp. 472-481 ◽  
Author(s):  
Cristina Cellurale ◽  
Nomeda Girnius ◽  
Feng Jiang ◽  
Julie Cavanagh-Kyros ◽  
Shaolei Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Gland Development

scholarly journals Abstract 5114: The role of amphiregulin in mammary gland development and breast cancer

2018 ◽  
Author(s):  
Serena Mao ◽  
Minji Park ◽  
Ramon Cabrera ◽  
John Christin ◽  
George Karagiannis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Gland Development

scholarly journals Early Steps of Mammary Stem Cell Transformation by Exogenous Signals; Effects of Bisphenol Endocrine Disrupting Chemicals and Bone Morphogenetic Proteins

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1351 ◽  
Author(s):  
Nora Jung ◽  
Veronique Maguer-Satta ◽  
Boris Guyot
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mammary Gland ◽  
Bone Morphogenetic Proteins ◽  
Mammary Gland Development ◽  
Cell Transformation ◽  
Current Knowledge ◽  
Endocrine Disrupting Chemicals ◽  
Normal Mammary Gland ◽  
Gland Development

Estrogens are major regulators of the mammary gland development, notably during puberty, via estrogen receptor (ER) activation, leading to the proliferation and differentiation of mammary cells. In addition to estrogens, the bone morphogenetic proteins (BMPs) family is involved in breast stem cell/progenitor commitment. However, these two pathways that synergistically contribute to the biology of the normal mammary gland have also been described to initiate and/or promote breast cancer development. In addition to intrinsic events, lifestyle habits and exposure to environmental cues are key risk factors for cancer in general, and especially for breast cancer. In the latter case, bisphenol A (BPA), an estrogen-mimetic compound, is a critical pollutant both in terms of the quantities released in our environment and of its known and speculated effects on mammary gland biology. In this review, we summarize the current knowledge on the actions of BMPs and estrogens in both normal mammary gland development and breast cancer initiation, dissemination, and resistance to treatment, focusing on the dysregulations of these processes by BPA but also by other bisphenols, including BPS and BPF, initially considered as safer alternatives to BPA.

scholarly journals ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

2014 ◽  
Vol 16 (10) ◽  
pp. 1004-1015 ◽  
Author(s):  
Rumela Chakrabarti ◽  
Yong Wei ◽  
Julie Hwang ◽  
Xiang Hang ◽  
Mario Andres Blanco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Cell Activity ◽  
Wnt Signalling ◽  
Stem Cell Activity ◽  
Basal Like Breast Cancer ◽  
Gland Development

The Role of Smoothened in Mammary Gland Development and Breast Cancer.

2009 ◽  
Author(s):  
A. Visbal ◽  
A. Visbal ◽  
H. Villanueva ◽  
H. Villanueva ◽  
J. Rosen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Gland Development
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